Results 241 to 250 of about 491,374 (284)

Engineered GM1 Intersects Between Mitochondrial and Synaptic Pathways to Ameliorate ALS Pathology

Advanced Science, EarlyView.
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease driven by genetic and molecular disruptions affecting energy balance, protein homeostasis, and stress responses in nerve cells. Studies using human and rodent models identified convergent defects in mitochondria and synaptic function.
Federica Pilotto, Tristan Dellazizzo Toth, Silvano Bond, Alexander Schmitz, Rim Diab, Sara Y. Ngo Tenlep, Brian Mooney, Silvia Erni, Martina Schobesberger, Olivier Scheidegger, Camille Peitsch, Smita Saxena   +11 more
wiley   +1 more source

Mothers against decapentaplegic homolog 4 as a proteomic hub in vascular remodeling and residual cardiovascular risk. [PDF]

World J Cardiol
Ramoni D, Carbone F, Liberale L, Montecucco F.   +3 more
europepmc   +1 more source

Proteogenomic integration reveals therapeutic targets in breast cancer xenografts [PDF]

, 2017
Cao, Song, Davies, Sherri R, Ding, Li, Erdmann-Gilmore, Petra, et al,, Guo, Zhanfang, Held, Jason M, Hoog, Jeremy, Huang, Kuan-lin, Li, Shunqiang, Ma, Cynthia, McLellan, Michael D, Niu, Beifang, Sanati, Souzan, Scott, Adam, Snider, Jacqueline E, Sun, Sam Qiancheng, Townsend, R. Reid, Wendl, Michael C, Wyczalkowski, Matthew A, Ye, Kai, Yoon, Christopher   +21 more
core   +1 more source

Quantitative Proteomics and CRISPR/Cas9 Editing Reveal UPR‐Mediated Control of Immunoglobulin Homeostasis in Hybridomas

Advanced Science, EarlyView.
BCR sequencing and subclone analysis correlated immunoglobulin (Ig) chain loss in dysfunctional hybridomas with disrupted monoclonal antibody homeostasis. Proteomics‐guided CRISPR/Cas9 editing revealed that the unfolded protein response (UPR) regulates aberrant Ig synthesis.
Rubing Zou, Xinying Lu, Ying Liu, Peiyu Yang, Shuo Sun, Yihua Liu, Yinyuan Mo, Guonian Zhu, Jae Seong Lee, Yirong Guo   +9 more
wiley   +1 more source

A plasma proteomic signature of the actin-coagulation axis accurately predicts progression to active tuberculosis. [PDF]

Front Microbiol
Lu P, Gao W, Ding X, Pan J, Ding H, Liu Q, Zhu L, Huo X.   +7 more
europepmc   +1 more source

Gut–Metabolome–Proteome Interactions in Age‐Related Hearing Loss: Insights from Fecal Microbiota Transplantation and Multi‐Omics Analyses

Advanced Science, EarlyView.
Germ‐free (GF) mice receiving fecal microbiota transplantation (FMT) reveal microbiota‐dependent effects on auditory aging. Integrated metagenomic, metabolomic and proteomic profiling maps gut–inner ear network and highlights 5‐hydroxytryptophan (5‐HTP) as a microbiota‐linked metabolic hub in age‐related hearing loss (ARHL).
Ting Yang, Ziwen Gao, Hui Huang, Chanyuan Zhang, Yiquan Tang, Qianhui Qu, Huabin Li, Jing Ke, Zhiji Chen, Menglong Feng, Hu Zhou, Yilai Shu, Wei Yuan   +12 more
wiley   +1 more source

Endometriosis-Associated Intestinal Tumor: A Case Report and Literature Review with Comprehensive Proteomic Data. [PDF]

Surg Case Rep
Toyota N, Yoshimatsu Y, Kamozawa C, Nakanishi R, Fujita S, Abe M, Konno R, Kawashima Y, Kondo T.   +8 more
europepmc   +1 more source

Proteomic Analysis of Cerebrospinal Fluid from Severe COVID-19 Patients Reveals Prognostic Biomarkers Associated with Disease Outcome. [PDF]

Proteomics Clin Appl
Alexopoulos H, Samiotaki M, Gkogkou E, Mavromati S, Bitzogli K, Panagiotou G, Tzioufas A, Magira E, Kotanidou Α, Trougakos I.   +9 more
europepmc   +1 more source

Proteomic atlas of human peritoneal tissue. [PDF]

Sci Rep
Zhang Q, Sherry C, Peng X, Fu Y, Vue N, Blodgett R, Park HY, Grayhack EE, Dadgar N, Li X, Zaidi AH, Donnenberg V, Bartlett DL, Donnenberg A, Xiao K, Wagner PL.   +15 more
europepmc   +1 more source