Results 161 to 170 of about 264,809 (238)

Olink Proteomics in Heart Failure: A Comprehensive Review of Applications From Biomarker Discovery to Pathophysiological Insights and Clinical Implementation. [PDF]

Rev Cardiovasc Med
Zheng Z, Gong Z, Gu J.
europepmc   +1 more source

Decoding Human Placental Cellular and Molecular Responses to Obesity and Fetal Growth

Advanced Science, EarlyView.
Women with obesity often deliver large‐for‐gestational‐age (LGA) infants. Single‐nucleus RNA sequencing of term placenta reveals that hypoxia and TNF‐α signaling in syncytiotrophoblasts are featured in maternal obesity, but inflammatory signatures in Hofbauer cells and response to lipid or carbohydrate metabolism in fibroblasts are specific to LGA.
Hong Jiang, Emilie Derisoud, Denise Parreira, Nayere Taebnia, Paulo R. Jannig, Reza Zandi Shafagh, Allan Zhao, Congru Li, Macarena Ortiz, Manuel Alejandro Maliqueo, Elisabet Stener‐Victorin, Volker M. Lauschke, Qiaolin Deng   +12 more
wiley   +1 more source

Correction: Paired proteomic analysis reveals protein alterations in sun-exposed skin of professional drivers

Scientific Reports
Amanda C. Camillo-Andrade, Lucas A. Sales, Juliana S. G. Fischer, Rosario Duran, Marlon D. M. Santos, Paulo C. Carvalho   +5 more
doaj   +1 more source

The ProteomeXchange consortium in 2026: making proteomics data FAIR. [PDF]

Nucleic Acids Res
Deutsch EW, Bandeira N, Perez-Riverol Y, Sharma V, Carver JJ, Mendoza L, Kundu DJ, Bandla C, Kamatchinathan S, Hewapathirana S, Sun Z, Kawano S, Okuda S, Connolly B, MacLean B, MacCoss MJ, Chen T, Zhu Y, Ishihama Y, Vizcaíno JA.   +19 more
europepmc   +1 more source

Lactylation‐Driven YTHDC1 Alleviates MASLD by Suppressing PTPN22‐Mediated Dephosphorylation of NLRP3

Advanced Science, EarlyView.
In MASLD, YTHDC1 undergoes increased lactylation and ubiquitination, reducing its expression. AARS1 mediates lactylation at lysine 565, while disrupted binding to LDHA further promotes lactylation, suppressing YTHDC1. This downregulation enhances PTPN22 mRNA stability, leading to NLRP3 dephosphorylation and activation, which exacerbates inflammation ...
Feng Zhang, Linghua Zeng, Kunkun Zou, Keying Lin, Fangting Yao, Jinglun Song, Shumeng Zhang, Hanshu Feng, Zhichao Yang, Chunlei Wang, Hongtao Diao, Xue Kong, Tengfei Pan, Joonki Kim, Tianqi Duo, Linqiang Li, Yu Bian   +16 more
wiley   +1 more source

Above-Filter Digestion Proteomics Reveals Drug Targets and Localizes Ligand Binding Site. [PDF]

J Proteome Res
Sokolova B, Gharibi H, Jafari M, Lyu H, Lovera S, Gaetani M, Saei AA, Zubarev RA.   +7 more
europepmc   +1 more source

Redefining Dendritic Cell Vaccines: Synergistically Co‐priming DC and B Cells With Nanoparticles Loading Whole Cell Antigens Maximizes the Efficacy of DC Vaccines

Advanced Science, EarlyView.
Dendritic cells (DC) vaccine is an important type of vaccines. However, the limited efficacy of DC vaccines hinders their widely application. This study redefines DC vaccines and provides a new DC‐BC vaccine that have much better therapeutic efficacy.
Xiangxiang Xu, Xianlan Chen, Jin Wang, Yuhan Liu, Sidra Mustafa, Lu Diao, Rongrong Zhao, Haiyang Chi, Kang Hu, Jiashan Zhu, Jun Zhao, Mi Liu   +11 more
wiley   +1 more source

Integration of clinical and proteomic risk factors enhances prognostic modelling of incident vascular complications in type 2 diabetes. [PDF]

Cardiovasc Diabetol
Huang Y, Tutino M, Singh A, Rayner NW, Barysenka A, Bocher O, Zeggini E.   +6 more
europepmc   +1 more source

A Mussel‐Inspired Bioadhesive Patch to Selectively Kill Glioblastoma Cells

Advanced Science, EarlyView.
An innovative mussel‐inspired bioadhesive patch has been developed for post‐surgical glioblastoma treatment. The patch, which adheres strongly in biological environments, releases a localized treatment. This treatment, acting via reactive oxygen species, shows specific toxicity to glioblastoma cells.
Jose Bolaños‐Cardet, Sara Pugliese, Jordi Bruna, Daniel Ruiz‐Molina, Salvio Suárez‐García, Victor J. Yuste   +5 more
wiley   +1 more source

A proteomics and redox proteomics approach to understanding ARDS heterogeneity. [PDF]

Sci Rep
Forshaw TE, Shukla K, Wu H, Sergeant S, Lee J, Tsang AW, Morris PE, Gibbs KW, Files DC, Furdui CM.   +9 more
europepmc   +1 more source