Results 241 to 250 of about 505,018 (335)

FACS-Proteomics strategy toward extracellular vesicles single-phenotype characterization in biological fluids: exploring the role of leukocyte-derived EVs in multiple sclerosis. [PDF]

J Transl Med
Cufaro MC, Lanuti P, De Bellis D, Veschi S, Piro A, Fontana A, Di Sebastiano A, Brocco D, Simeone P, Pilato S, Khorooshi RMH, Tomassini V, Rispoli MG, Federici L, Cicalini I, Pieragostino D, Del Boccio P.   +16 more
europepmc   +1 more source

Integrating genomics and proteomics [PDF]

, 2001
Jonathan B Weitzman
openalex   +1 more source

Engineered Foxp1high Exosomes Ameliorates Systemic Lupus Erythematosus

Advanced Science, EarlyView.
This study presents a dual‐engineering strategy combining mesenchymal stem cell aggregation and Foxp1 overexpression to generate Foxp1high aggregation exosomes with enhanced immunomodulatory properties. These engineered exosomes exhibit immune organ targeting and superior efficacy in systemic lupus erythematosus treatment by promoting Treg ...
Luhan Niu, Qianmin Ou, Qianhui Ren, Zhengshi Li, Hongcheng Chen, Fangcao Lei, Xueli Mao, Songtao Shi, Zetao Chen, Wei Teng   +9 more
wiley   +1 more source

Precision Medicine and the Human Proteome in Disease, Diagnostics and Translation: Current Status and Future Prospects. [PDF]

Biomedicines
Qoronfleh MW.
europepmc   +1 more source

An Injectable BMP‐2‐Releasing Porous Hydrogel Regulating the Paracrine Effects of ADSCs Promotes Tendon‐to‐Bone Healing in Rotator Cuff Repair

Advanced Science, EarlyView.
This study designs an injectable porous hydrogel (HMs/MBs/ADSCs) integrating hollow microspheres for sustained BMP‐2 release to enhance adipose‐derived stem cells' paracrine effect. It accelerates tendon‐bone healing in rat rotator cuff injuries via spatiotemporal regulation: early AMPK‐mediated mitochondrial protection and late TGF‐β/Smad2/3‐driven ...
Meijuan Yuan, Xiaomei Dai, Yuxia Yang, Shuai Liu, Ziyi Xu, Liang Wang, Junli Shi, Wenkang Liu, Jian Yang, Dianwei Liu, Hang Yao, Wenyong Fei   +11 more
wiley   +1 more source

Overcoming Analytical Challenges in Proximity Labeling Proteomics. [PDF]

J Mass Spectrom
Li H, Mazli WNAB, Hao L.
europepmc   +1 more source

Eosinophils‐Induced Lumican Secretion by Synovial Fibroblasts Alleviates Cartilage Degradation via the TGF‐β Pathway Mediated by Anxa1 Binding

Advanced Science, EarlyView.
Eosinophils play a crucial role in the progression of temporomandibular joint osteoarthritis (TMJOA). This study demonstrates that eosinophils, induced by OVA/IL‐5, promote Lumican secretion in the synovium, which binds to Annexin A1 in chondrocytes, inhibiting transforming growth factor β2 and Smad2/3 phosphorylation.
Wenqian Chen, Yuwei Zhou, Wenxiu Yuan, Yanjing Ou, Hanyu Lin, Kaixun He, Xueshen Qian, Huachen Chen, Chengchaozi Wang, Jie Lu, Weiping Chen, Dexiong Li, Jiang Chen   +12 more
wiley   +1 more source

Interpretable machine learning leverages proteomics to improve cardiovascular disease risk prediction and biomarker identification. [PDF]

Commun Med (Lond)
Climente-González H, Oh M, Chajewska U, Hosseini R, Mukherjee S, Gan W, Traylor M, Hu S, Fatemifar G, Ghouse J, Del Villar PP, Vernet E, Koelling N, Du L, Abraham R, Li C, Howson JMM.   +16 more
europepmc   +1 more source

Post‐Translational Modifications in Cilia and Ciliopathies

Advanced Science, EarlyView.
This review synthesizes current understanding of post‐translational modifications (PTMs) in ciliary proteins and emphasizes their roles in ciliary formation, homeostasis, and signaling. This review also discusses the implication of PTM dysregulation in ciliopathies and explores therapeutic strategies targeting PTM‐modifying enzymes.
Jie Ran, Jun Zhou
wiley   +1 more source

Benchmarking SILAC Proteomics Workflows and Data Analysis Platforms. [PDF]

Mol Cell Proteomics
Frankenfield AM, Yang KL, Mazli WNAB, Shih J, Yu F, Lo E, Nesvizhskii AI, Hao L.   +7 more
europepmc   +1 more source