Results 271 to 280 of about 490,947 (358)

Plasma-to-tumour tissue integrated proteomics using nano-omics for biomarker discovery in glioblastoma. [PDF]

Nat Commun
Liu X, Abmanhal-Masarweh H, Iwanowytsch O, Okwelogu E, Arashvand K, Karabatsou K, Ivo D'Urso P, Roncaroli F, Kostarelos K, Kisby T, Hadjidemetriou M.   +10 more
europepmc   +1 more source

Hierarchical Regulatory Networks Reveal Conserved Drivers of Plant Drought Response at the Cell‐Type Level

Advanced Science, EarlyView.
This study presents a comprehensive multi‐omics framework to uncover cell‐type‐specific regulatory networks in plant drought responses. By integrating transcriptomic, proteomic, and epigenetic data from nearly 30 000 samples, key regulators such as CIPK23 and NLP7 are identified, revealing insights into conserved drought tolerance mechanisms and ...
Moyang Liu, Yuanyuan Xu, Yue Song, Dongying Fan, Junpeng Li, Zhen Zhang, Lujia Wang, Juan He, Cheng Chen, Chao Ma   +9 more
wiley   +1 more source

Micro-proteomics reveals distinct protein profiles and SPARC/FGF2/CDH1 regulation of human Sertoli cells between Sertoli cell-only syndrome and normal men. [PDF]

Cell Mol Life Sci
Du L, Cui Y, Chen W, Li C, He Z.
europepmc   +1 more source

Diallyl Trisulfide From Garlic Regulates RAB18 Phase Separation to Inhibit Lipophagy and Induce Cuproptosis in Hepatic Stellate Cells for Antifibrotic Effects

Advanced Science, EarlyView.
Diallyl trisulfides (DATs) selectively induce cuproptosis in hepatic stellate cells (HSCs) by targeting Ras‐related protein Rab‐18 (RAB18) and regulating lipophagy. DATs promote RAB18 phase separation, enhance mitochondrial‐associated membrane structures (MAMs) formation, and increase succinylation of dihydrolipoamide dehydrogenase (DLD) at K320.
Haoyuan Tian, Shujiang Sun, Xinran Qiu, Junrui Wang, Yuanyuan Gao, Jianmei Chen, Xiang Han, Zhengyang Bao, Xiaohan Guo, Yuqi Sun, Yuxin Lin, Mengru Hu, Feng Zhang, Zili Zhang, Feixia Wang, Shizhong Zheng, Jiangjuan Shao   +16 more
wiley   +1 more source

Application of Spatial Omics in the Cardiovascular System. [PDF]

Research (Wash D C)
Hu Y, Jia H, Cui H, Song J.
europepmc   +1 more source

RAB3B Dictates mTORC1/S6 Signaling in Chordoma and Predicts Response to mTORC1‐Targeted Therapy

Advanced Science, EarlyView.
RAB3B is unveiled as a prominent oncogenic regulator in chordoma, which can block the DUSP12‐mediated dephosphorylation of p‐S6 (S235/236). The combination of RAB3B and p‐S6 indicates a good prognostic value and predicts mTORC1 inhibitors response for chordoma patients.
Jianxuan Gao, Jiali Jin, Runzhi Huang, Siqiao Wang, Sihui Song, Yu Zhang, Yongai Li, Jun Lin, Zhengyan Chang, Zongqiang Huang, Wei Sun, Huabin Yin, Dianwen Song, Jianru Xiao, Ping Wang, Tong Meng   +15 more
wiley   +1 more source

Evaluating sample normalization methods for MS-based multi-omics and the application to a neurodegenerative mouse model.

Analyst
Lee GB, Yang C, Hu F, Hao L.
europepmc   +1 more source

Histopathology and proteomics are synergistic for high-grade serous ovarian cancer platinum response prediction. [PDF]

NPJ Precis Oncol
Kilim O, Olar A, Biricz A, Madaras L, Pollner P, Szállási Z, Sztupinszki Z, Csabai I.   +7 more
europepmc   +1 more source

In Vivo Reprogramming of Tissue‐Derived Extracellular Vesicles for Treating Chronic Tissue Injury Through Metabolic Engineering

Advanced Science, EarlyView.
Inspired by exercise‐induced metabolic rewiring and EV secretion, this study shows that in vivo metabolic engineering strategy can reprogram EV secretion pattern and simultaneously attenuate multiple tissue injury in CKD status, highlighting that it is a potential strategy for treating diverse chronic diseases.
Meng Zhao, Shuyun Liu, Yizhuo Wang, Peng Lou, Ke Lv, Tian Wu, Lan Li, Qianyi Wu, Jiaying Zhu, Yanrong Lu, Meihua Wan, Jingping Liu   +11 more
wiley   +1 more source

Integrative network analysis reveals novel moderators of Aβ-Tau interaction in Alzheimer's disease. [PDF]

Alzheimers Res Ther
Kitani A, Matsui Y, Alzheimer’s Disease Neuroimaging Initiative.   +2 more
europepmc   +1 more source