Results 291 to 300 of about 521,206 (335)

Causal effects and mediation pathways of circulating plasma proteins on osteoporosis: a two-sample and two-step Mendelian randomization study. [PDF]

Clin Proteomics
Wang H, Zhou W, Huang Y, Li Y, Zhang K.
europepmc   +1 more source

GLS1‐RNA Polymerase II Axis Mediates Glutamine‐Dependent Hepatoprotective Effects on Alcoholic Liver Disease in High‐Protein Diets

Advanced Science, EarlyView.
GLS1 interacts with RNA polymerase II subunits, ROLR2H and POLR2E, resulting in significant suppression of RNA polymerase II activity. Importantly, the investigation demonstrates that high‐protein diets, particularly glutamine, exert protective effects against alcoholic fatty liver through GLS1‐RNA polymerase II axis.
Wenbiao Wu, Haowen Jiang, Yichang Liu, Chang Peng, Hanlin Wang, Wenhua Yang, Zan Lyu, Yan Sun, Huan Ma, Hongyu Gu, Weijuan Kan, Liya Jing, Tiancheng Dong, Chunmei Xia, Saifei Lei, Rui Wu, Jinlong Li, Jia Li   +17 more
wiley   +1 more source

Insights from Mass Spectrometry-Based Proteomics on <i>Cryptococcus neoformans</i>. [PDF]

J Fungi (Basel)
Betancourt JJ, Nielsen K.
europepmc   +1 more source

Physiological pH Transition‐Driven Protein Corona Dynamics Regulate Cellular Uptake and Inflammatory Responses of Silica Nanoparticles

Advanced Science, EarlyView.
Physiological pH transitions modulate protein corona dynamics on nanoparticles, altering their cellular uptake and inflammatory responses. Acidic pHs enhance protein adsorption, induce structural changes, and promote cellular uptake. Simultaneously, inflammatory responses are reduced due to altered protein composition, including decreased ...
Yuting Ge, Fangqin Fu, Yu Gao, Tianchang He, Volker Mailänder, Daniel Crespy, Katharina Landfester, Shuai Jiang   +7 more
wiley   +1 more source

Collagen proteins, thrombospondin 1 and lumican are differentially expressed across breast cancer subtypes by functional proteomics from core needle biopsy samples of Taiwanese breast cancer. [PDF]

Biochem Biophys Rep
Ku WC, Phan NN, Liu CY, Huang CJ, Liao CC, Huang YC, Kong PH, Tseng LM, Huang CC.   +8 more
europepmc   +1 more source

Sanggenol L Enhances Temozolomide Drug Sensitivity by Inhibiting Mitophagy and Inducing Apoptosis Through the Regulation of the TRIM16‐OPTN Axis in Glioblastoma

Advanced Science, EarlyView.
Sanggenol L, a flavonoid from mulberry, enhances glioblastoma sensitivity to temozolomide by inhibiting mitophagy and inducing apoptosis through TRIM16‐mediated OPTN degradation. In animal studies, liposomal delivery of Sanggenol L significantly improves the efficacy of its combination with TMZ, providing new insights into glioblastoma treatment ...
Hongbo Chang, Jianbing Hou, Xin Hu, Nana Hou, Minghao Xu, Yi Du, Jingyang Xu, Yongzhao Wang, Zhuohao Xie, Junbo Shi, Yundong Zhang, Hongjuan Cui   +11 more
wiley   +1 more source

Recommendations for Quantitative Data-Independent Acquisition (DIA) Proteomics using Controlled Quantitative Experiments (CQEs)

Frey AM, Sidgwick F, Porter A, Palmowski P, Trost M.   +4 more
europepmc   +1 more source

Discovery of a Potent and Selective TEAD Degrader with Durable Degradation Activity

Advanced Science, EarlyView.
KG‐FP‐003, a highly potent TEAD‐YAP PROTAC derived from the patented inhibitor is developed. It selectively degrades endogenous TEAD proteins in HiBiT systems without IMiD‐related off‐target effects. Screening across 867 cancer cell lines revealed broad and superior anti‐tumor activity, highlighting its therapeutic potential through targeted TEAD ...
Linhui Cao, Jing Yang, Yuhang Liu, Xiaotong Chen, Yufang Shi, Yunshuo Zhao, Yong Zhang, Jian Chen, Bowen Li, Wuqiang Wen, Lu Chen, Bo Peng, Lu Huang, Yanli Sun, Lixin Zhou, Matthew G Rees, Melissa M Ronan, Jennifer A Roth, Zhixiang Guo, Jing Xing, Guangya Zhu, Yazhou Wang, Baishan Jiang, Jing Lu, Kehao Zhao, Wenchao Lu   +25 more
wiley   +1 more source

Protein cleaver: an interactive web interface for <i>in silico</i> prediction and systematic annotation of protein digestion-derived peptides. [PDF]

Front Bioinform
Koulouras G, Xu Y.
europepmc   +1 more source

The coming era of proteomics-driven precision medicine. [PDF]

Natl Sci Rev
Jiang Y, Wang J, Sun A, Zhang H, Yu X, Qin W, Ying W, Li Y, Chang C, Wang X, Xie L, Liu W, Liu J, Zhang X, Yan Q, Zou Y, Zhao C, Sun H, Zhang J, Su S, Gao Q, He F.   +21 more
europepmc   +1 more source