Results 81 to 90 of about 147,662 (251)

Selective TiO₂ Phosphopeptide Enrichment of Complex Samples in the Nanogram Range

Separations, 2020
Phosphopeptide enrichment is a commonly used sample preparation step for investigating phosphorylation. TiO2-based enrichment has been demonstrated to have excellent performance both for large amounts of complex and for small amounts of simple samples ...
Gábor Tóth, Fanni Bugyi, Simon Sugár, Goran Mitulović, Károly Vékey, Lilla Turiák, László Drahos   +6 more
doaj   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

The Green Proteome: Challenges in Plant Proteomics [PDF]

Frontiers in Plant Science, 2011
An organism is an expression of its underlying molecular composition that reacts and responds to a variety of stimuli. Central to this response are proteins, which undertake a multitude of functional and structural roles throughout an organism.
openaire   +3 more sources

Early sex-related transcriptional differences in CD8+ T cells responding to chronic viral infection reveal a sex bias in exhaustion

Frontiers in Immunology
CD8+ T cell diversity is essential to control infections and chronic antigen stimulation. In acute-resolving infection, effector cells mediate acute responses and memory cells provide long-lived protection against future exposures.
Nyambura Kahia, Nyambura Kahia, Sean M. Robertson, Megan Rodriguez, Paul Jerard Layug, Harman Vats, Kamali Kannan, Kamali Kannan, Victor Spicer, Arzu Ozturk-Aptekmann, Olivia Wilkins, Janilyn Arsenio, Janilyn Arsenio, Janilyn Arsenio   +13 more
doaj   +1 more source

Learning important features from multi-view data to predict drug side effects

Journal of Cheminformatics, 2019
The problem of drug side effects is one of the most crucial issues in pharmacological development. As there are many limitations in current experimental and clinical methods for detecting side effects, a lot of computational algorithms have been ...
Xujun Liang, Pengfei Zhang, Jun Li, Ying Fu, Lingzhi Qu, Yongheng Chen, Zhuchu Chen   +6 more
doaj   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

PD-L1 Expression in Acute Myeloid Leukemia Cells: Associations With Cell Metabolism

Journal of Immunology Research
The programmed death ligand 1 (PD-L1) is a prominent mediator of immune system inhibition in various cancer types. In acute myeloid leukemia (AML), the prognostic meaning of PD-L1 expression is still unclear and likely depends on the mechanism of its ...
Tereza Kořánová, Barbora Brodská, Antonín Ptáček, Petra Otevřelová, Marek Jedlička, Jan Musil, Zdenka Gašová, Jan Válka, Kateřina Kuželová   +8 more
doaj   +1 more source

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

Molecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic, Rafael Stroggilos, Mladen Marinkovic, Ana Djuric, Suzana Stojanovic‐Rundic, Radmila Jankovic, Sergi Castellvi‐Bel, Remond J.A. Fijneman, Antonia Vlahou, Jerome Zoidakis, Milena Cavic   +10 more
wiley   +1 more source

metaProt: A Proteomics Metaclassification

, 2008
There is a recognized need for a proteomics metaclassification which can serve as a foundation for more refined classifications and ontologies. metaProt is a manually curated proteomics metaclassification, comprising a large collection of relations ...
Proteomics Metaclassification, Anand Kumar Ab   +1 more
core  

Recent advances in blood‐related proteomics

, 2005
Blood is divided in two compartments, namely, plasma and cells. The latter contain red blood cells, leukocytes, and platelets. From a descriptive medical discipline, hematology has evolved towards a pioneering discipline where molecular biology has ...
Pierre‐Alain Queloz, David Crettaz, Michèle A. Siegenthaler, Philippe Schneider, Jean‐Daniel Tissot, Lynne Thadikkaran, Siegenthaler, M. A., Queloz, P. A., Crettaz, D., Tissot, J. D., Thadikkaran, L., Schneider, P.   +11 more
core   +1 more source