Results 81 to 90 of about 218,532 (388)

STEM-ОРІЄНТОВАНЕ НАВЧАННЯ АРХІТЕКТУРИ КОМП’ЮТЕРА У ФОРМУВАННІ ІНЖЕНЕРНОГО МИСЛЕННЯ МАЙБУТНІХ УЧИТЕЛІВ ІНФОРМАТИКИ

Фізико-математична освіта
Формулювання проблеми. У статті обґрунтовано педагогічну доцільність використання симуляційного середовища Proteus у процесі STEM-орієнтованого навчання курсу «Архітектура комп’ютера» з метою формування інженерного мислення студентів.
Володимир Шамоня, Максим Сорока, Олена Семеніхіна   +2 more
doaj   +1 more source

A dyadic genotype–phenotype approach to diagnostic criteria for Proteus syndrome

American Journal of Medical Genetics. Part C, Seminars in Medical Genetics, 2019
Phenotype‐based diagnostic criteria were developed for Proteus syndrome in 1999 and updated in 2006. Subsequently, the causative mosaic gene alteration was discovered, the c.49G>A p.E17K variant in AKT1.
Julie C. Sapp, A. Buser, Jasmine Burton-Akright, K. Keppler-Noreuil, L. Biesecker   +4 more
semanticscholar   +1 more source

Restoring Iron Homeostasis via Smoothened Inhibition: A Novel Strategy Against Hearing Loss

Advanced Science, EarlyView.
 . ABSTRACT Sensorineural hearing loss (SNHL) induced by noise or aminoglycoside antibiotics is a significant public health concern without any FDA‐approved pharmaceutical therapies. Dysregulation of iron homeostasis and its subsequently induced ferroptosis has increasingly been identified as a key mechanism underlying cochlear hair cell (HC) damage ...
Huanyu Mao, Xiang Li, Yaqi Liao, Liman Liu, Xian Gao, Hailiang Lin, Wenli Ni, Huawei Li, Yan Chen, Wenyan Li   +9 more
wiley   +1 more source

Effect of Physical and Chemical Changes on the Antimicrobial Activity of Culture Supernatant Fluid of Lactic Acid Bacteria

Medical Laboratory Journal, 2016
Background and Objective: Lactic acid bacteria are Gram-positive, catalase-negative, nonsporulating, either rod- or coccus-shaped bacteria that have beneficial effects on their hosts by producing antimicrobial substances such as lactic acid, hydrogen ...
Leila Goudarzi, Rouha Kasra Kermanshahi, Zahra Moosavi-Nejad   +2 more
doaj  

Cis‐ and Trans‐Regulatory Factors Independently Shape Phenotypic Heterogeneity of Retinitis Pigmentosa

Advanced Science, EarlyView.
A zebrafish model carrying an identical human RHO S334X allele reveals two independent genetic layers shaping retinitis pigmentosa (RP) severity: a protective 3‐bp cis‐regulatory insertion that attenuates transgene expression, and a dominant trans‐acting modifier that restores a severe phenotype.
Cong Cui, Kotone Nakagawa, Takumi Tateno, Ayaka Dan, Dexin Meng, Yoshihiro Omori, Soma Tomihara, Suzuri Okamoto, Shigeru Sato, Motokazu Tsujikawa   +9 more
wiley   +1 more source

The »Trebinje Proteus Observatorium and Proteus Rescue and Care Facility«, Bosnia and Herzegovina

Natura Sloveniae, 2018
n ...
Brian Lewarne
doaj   +1 more source

Multilocus sequence analysis for the taxonomic updating and identification of the genus Proteus and reclassification of Proteus genospecies 5 O’Hara et al. 2000, Proteus cibarius Hyun et al. 2016 as later heterotypic synonyms of Proteus terrae Behrendt et al. 2015

BMC Microbiology, 2020
Background Members of the genus Proteus are mostly opportunistic pathogens that cause a variety of infections in humans. The molecular evolutionary characteristics and genetic relationships among Proteus species have not been elucidated to date.
Hang Dai, Binghuai Lu, Zhenpeng Li, Zhenzhou Huang, Hongyan Cai, Keyi Yu, Duochun Wang   +6 more
doaj   +1 more source

An assessment of the antibacterial activity in larval excretion/secretion of four species of insects recorded in association with corpses, using Lucilia sericata Meigen as the marker species [PDF]

, 2010
The relative antibacterial activities of excretion/secretion (ES) from two carrion-feeding insects, Calliphora vicina Robineau-Desvoidy and Dermestes maculatus DeGeer, and a detritivore, Tenebrio molitor Linnaeus, were compared to that of Lucilia ...
D.E. Gennard, Gennard, K.M. Barnes, Mégnin, R.A. Dixon, Reinecke   +5 more
core   +2 more sources

Divergent Roles of mGlu2 and mGlu3 Receptors in Amyloid‐β Production and Cognitive Dysfunctions in Alzheimer's Disease

Advanced Science, EarlyView.
This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon, Mireille Elodie Tsitokana, Ugo Guy Alenda, Yen‐Ling Lian, Clémentine Eva Philibert, Mathieu Oosterlaken, Marta Cimadevila, Gaëlle Dudon, Jessica Monnic, Salomé Roux, Julie Bessié, Séverine Diem, Franck Vandermoere, Laurent Prézeau, Patrick Chames, Julie Kniazeff, Sylvie Claeysen, Anaïs Menny, Jean‐Philippe Pin, Véronique Perrier, Jianfeng Liu, Philippe Rondard   +21 more
wiley   +1 more source

Antimicrobial Susceptibility Trends Observed in Urinary Pathogens Obtained From New York State [PDF]

, 2018
International guidelines recommend using local susceptibility data to direct empiric therapy for acute uncomplicated cystitis. We evaluated outpatient urinary isolate susceptibility trends in New York State.
Avery, Lisa M., Bankert, Eve, Carreno, Joseph J., Dobson, Erica, Dumyati, Ghinwa, Hassett, Stephen, Keller, Marina, Lodise, Thomas, Lubowski, Theresa, Pearsall, Matthew, Rank, Elliot L.   +10 more
core   +1 more source