Results 311 to 320 of about 161,310 (344)
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[Rinsho ketsueki] The Japanese journal of clinical hematology, 2021
Dysprothrombinemia is the rarest inherited bleeding disorder that is characterized by a decrease in the prothrombin activity, but normal antigen levels. In this study, we report the case of a compound heterozygote of two mutations in prothrombin; Met337Thr and Arg388His, which has previously been identified as "Prothrombin Himi." A systemic blood ...
Yusuke Kamihara +7 more
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Dysprothrombinemia is the rarest inherited bleeding disorder that is characterized by a decrease in the prothrombin activity, but normal antigen levels. In this study, we report the case of a compound heterozygote of two mutations in prothrombin; Met337Thr and Arg388His, which has previously been identified as "Prothrombin Himi." A systemic blood ...
Yusuke Kamihara +7 more
openaire +2 more sources
Decarboxylation of bovine prothrombin fragment 1 and prothrombin [PDF]
Biochemistry, 1979 Bovine prothrombin fragment 1 and prothrombin undergo decarboxylation of their gamma-carboxyglutamic acid residues when the lyophilized proteins are heated in vacuo at 110 degrees C for several hours. The fully decarboxylated fragment 1 product has lost its barium-binding ability as well as the calcium-binding function which causes fluorescence ...
Kenneth G. Mann +2 more
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Prothrombin madrid : A new familial abnormality of prothrombin
Thrombosis Research, 1979Abstract An abnormal prothrombin has been detected in a 13 yr-old girl, with history of excessive bleeding. Prothrombin time and activated partial thromboplastin time were markedly prolonged. Prothrombin activity was very low when measured by biological assay using either physiological activators (3% by one stage assay and 20 US u/ml by two stage ...
A. Bezeaud +4 more
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American Journal of Physiology-Legacy Content, 1956
In the activation of a prothrombin solution, only part of the prothrombin becomes biothrombin, some becomes autoprothrombin I and some becomes autoprothrombin II. Thrombin-thrombin is also obtained, and perhaps other derivatives of prothrombin are formed. Prothrombin thus has multiple potentialities and these can be developed in diverse ways.
J A, PENNER, W H, SEEGERS
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In the activation of a prothrombin solution, only part of the prothrombin becomes biothrombin, some becomes autoprothrombin I and some becomes autoprothrombin II. Thrombin-thrombin is also obtained, and perhaps other derivatives of prothrombin are formed. Prothrombin thus has multiple potentialities and these can be developed in diverse ways.
J A, PENNER, W H, SEEGERS
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Journal of the American Medical Association, 1947
To the Editor:— The recent current comment on Stability of Prothrombin inThe Journal, September 9, page 36, contains Certain statements to which I am compelled to take exception; particularly to one: "Unreliable values for prothrombin obtained by the one stage method etc." It might be well to inquire concerning the actual facts.
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To the Editor:— The recent current comment on Stability of Prothrombin inThe Journal, September 9, page 36, contains Certain statements to which I am compelled to take exception; particularly to one: "Unreliable values for prothrombin obtained by the one stage method etc." It might be well to inquire concerning the actual facts.
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Prothrombin Metz : Purification and Characterization of a Variant of Human Prothrombin [PDF]
Thrombosis and Haemostasis, 1979 For the purification of the abnormal prothrombin (Pt Metz), advantage has been taken of the existence in the family of three siblings who, being double heterozygotes for Pt Metz and a hypoprothrombinemia, have no normal Pt. Purification procedures included barium citrate adsorption and chromatography on DEAE Sephadex as for normal Pt.
J Elion, M Ribieto, D Labie, F Josso
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Prothrombin Segovia: A new congenital abnormality of prothrombin
Scandinavian Journal of Haematology, 1986A family with a new congenital dysprothrombinemia is presented. The propositus is a 21‐yr‐old man who presented simultaneously with hemartrosis of the left knee and an extensive hematoma following a minor trauma. Prothrombin time and activated partial thromboplastin time were prolonged.
P. R. Fisac +5 more
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Lupus, 2012
Research on antiphospholipid antibodies (aPL) and the thrombotic manifestations associated with these antibodies has grown since the description of anticardiolipin antibodies (aCL) by Harris and colleagues in the early 1980s. Antiprothrombin (aPT) antibodies are commonly detected by ELISA, using irradiated plates (aPT) or prothrombin in complex with ...
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Research on antiphospholipid antibodies (aPL) and the thrombotic manifestations associated with these antibodies has grown since the description of anticardiolipin antibodies (aCL) by Harris and colleagues in the early 1980s. Antiprothrombin (aPT) antibodies are commonly detected by ELISA, using irradiated plates (aPT) or prothrombin in complex with ...
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Prothrombin Poissy: a new variant of human prothrombin
British Journal of Haematology, 1987SummaryA new congenital dysprothrombinaemia is described in a newborn baby girl who presented severe bleeding from the second day of life. Routine coagulation tests showed very prolonged prothrombin time and activated partial thromboplastin time with about 2% prothrombin activity in a one‐stage assay.
A. Bros +5 more
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Polymorphisms in the Prothrombin Gene and their Association with Plasma Prothrombin Levels [PDF]
Thrombosis and Haemostasis, 2001 SummaryTo find genetic causes of high plasma prothrombin levels, an established prothrombotic risk factor, we searched for sequence variations in the prothrombin gene. We selected subjects with the 20210-GG genotype (since the 20210-A allele is already known to be associated with high levels) and elevated prothrombin levels (≥ 130 U/dl) from the Leiden
F.R. Rosendaal +4 more
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