Results 321 to 330 of about 161,310 (344)
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Electroimmunoassay of prothrombin
Thrombosis Research, 1987Electroimmunoassay of normal (10-Gla) and Gla-deficient prothrombins containing 0 to 9 Gla (gamma-carboxyglutamyl) residues performed in EDTA against anti- (normal) prothrombin showed that each of the Gla-deficient proteins contained as much antigenic activity as does the normal molecule. In the presence of Ca2+, however, normal prothrombin appeared to
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Congenital Prothrombin Deficiency
Seminars in Thrombosis and Hemostasis, 2009Prothrombin deficiency is among the rarest inherited coagulation disorders, with a prevalence of approximately 1:2,000,000. Two main phenotypes can be distinguished: (1) hypoprothrombinemia (type I deficiency), characterized by concomitantly low levels of activity and antigen; and (2) dysprothrombinemia (type II deficiency), characterized by the normal
Lancellotti, Stefano +1 more
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Preparation of bovine prothrombin complex and purified prothrombin
Thrombosis Research, 1972Abstract A simplified procedure is described for the large-scale purification of bovine prothrombin complex. The protein was adsorbed on barium carbonate, eluted with 3.5% sodium citrate solution, and fractionated with ammonium sulfate. Additionally, prothrombin was separated from autoprothrombin III (Factor X) and further purified by DEAE-cellulose ...
Walter H. Seegers, Lowell E. McCoy
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British Journal of Haematology, 1983
Summary. A Cuban family with a new congenital dysprothrombinaemia is described. The propositus was a 5‐year‐old female who presented with umbilical bleeding after birth followed by easy bruising and bleeding tendency throughout her life. The main laboratory features of the defect included prolongation of prothrombin time and partial thromboplastin ...
Cruz A, R. Rubio, Corral Jf, Almagro D
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Summary. A Cuban family with a new congenital dysprothrombinaemia is described. The propositus was a 5‐year‐old female who presented with umbilical bleeding after birth followed by easy bruising and bleeding tendency throughout her life. The main laboratory features of the defect included prolongation of prothrombin time and partial thromboplastin ...
Cruz A, R. Rubio, Corral Jf, Almagro D
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Prothrombin Activation in Rabbits
Thrombosis Research, 1999The suitability of rabbit prothrombin activation fragment F 1.2 as a marker for the activation of the coagulation system was tested. Monoclonal antibodies to rabbit F 1.2 were raised, and a competitive F 1.2 ELISA was developed. Within the detection limit of the ELISA, no increase in rabbit F 1.2 was detected upon recalcification of plasma, whereas ...
Martin Thoolen +6 more
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Monoclonal antibodies to prothrombin
Thrombosis Research, 1987Hybridoma technology was used for the production of murine monoclonal antibodies to bovine normal prothrombin. Hybrid cell cultures were assayed for the production of antibodies, both in the absence and presence of calcium ions, by Enzyme-Linked Immunosorbent Assay (ELISA). Antibody-producing cell lines were cloned two times and grown as ascites tumors.
Oscar Sudilovsky, Om P. Malhotra
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The Preparation of Prothrombin-Free Ox Plasma in the Estimation of Prothrombin
Scandinavian Journal of Clinical and Laboratory Investigation, 1953AbstractOxalated ox plasma treated with barium sulphate (2 g) per 100 ml) is suitable in the estimation of prothrombin activity by the method described by Owren. The preparation is simple and cheapqr than the original procedure.
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CHARACTERIZATION OF A VARIANT OF HUMAN PROTHROMBIN: PROTHROMBIN MADRID [PDF]
Annals of the New York Academy of Sciences, 1981 Marie-Claude Guillin, Annie Bezeaud
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