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Thromboplastin Time (Prothrombin Time)
1965Publisher Summary This chapter elaborates thromboplastin time that is, prothrombin time. Blood plasma contains 300–400 mg% fibrinogen, and during coagulation of blood this is converted to insoluble fibrin by thrombin. The highly active enzyme thrombin is formed from an inactive precursor, prothrombin.
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JAMA: The Journal of the American Medical Association, 1965
To the Editor:— Oral anticoagulation remains a complicated subject involving many facets, but one variable could be made a constant if the one-stage prothrombin time were carried out by the standard technique outlined over 25 years ago, when I explicitly described the preparation of thromboplastin.
Armand J. Quick, Herbert S. Sise
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To the Editor:— Oral anticoagulation remains a complicated subject involving many facets, but one variable could be made a constant if the one-stage prothrombin time were carried out by the standard technique outlined over 25 years ago, when I explicitly described the preparation of thromboplastin.
Armand J. Quick, Herbert S. Sise
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Simplified Prothrombin Time Standardization
Pathophysiology of Haemostasis and Thrombosis, 1994An analysis of prothrombin time (PT) standardization methods is presented. The present recommended ratio method demonstrated complex calibration and wide therapeutic ranges. Standardization by coagulation activities resulted in different therapeutic ranges due to the different sensitivity of assays for the protein induced by vitamin K absence (Pivka ...
Ingebrigt Talstad, Knut Korsbrekke
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The prothrombin time test [PDF]
The prothrombin time (PT) is the screening test for the extrinsic (tissue) clotting system. The PT was originally introduced by Quick1 as a measure of a coagulation defect in the newborn and jaundiced patients, and subsequently adapted for its present principal uses in the screening of extrinsic clotting and in monitoring of oral anticoagulant dosage ...
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Investigation of prothrombin time in human whole-blood samples with a quartz crystal biosensor.
Analytical Chemistry, 2010Monitoring of blood coagulation and fibrinolysis is an important issue in treatment of patients with cardiovascular problems and in surgery when blood gets into contact with artificial surfaces.
Lothar Müller+6 more
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The action of Dicumarol in the human being on plasma prothrombin time and total prothrombin time
American Heart Journal, 1952Abstract In man, Dicumarol causes an increase in the plasma and in the total prothrombin times. The explanation is offered that Dicumarol reduces both the free and total prothrombin and that a rough ratio between the two forms is maintained. The practical significance of this observation is discussed.
Clara V. Hussey+5 more
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The prothrombin time (PT) is the screening test for the extrinsic (tissue) clotting system. The PT was originally introduced by Quick1 as a measure of a coagulation defect in the newborn and in jaundiced patients, and subsequently adapted for its present principal uses in the screening of extrinsic clotting and in monitoring of oral anticoagulant ...
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American Journal of Clinical Pathology, 1985
A chromogenic prothrombin time (CPT) has been compared with the standard prothrombin time (PT) or activated partial thromboplastin time (aPTT) in evaluating the hemostatic abnormality in patients with specific clotting factor deficiencies or liver disease and in patients receiving anticoagulant or fibrinolytic therapy.
Jane E. Malone+2 more
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A chromogenic prothrombin time (CPT) has been compared with the standard prothrombin time (PT) or activated partial thromboplastin time (aPTT) in evaluating the hemostatic abnormality in patients with specific clotting factor deficiencies or liver disease and in patients receiving anticoagulant or fibrinolytic therapy.
Jane E. Malone+2 more
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THE PROTHROMBIN TIME IN DICOUMAROL THERAPY
Annals of Internal Medicine, 1949Excerpt The identification of dicoumarol as the cause of sweet clover disease was made by Link in 1939.
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Anticoagulants and Prothrombin Time
Medical Journal of Australia, 1978S. Gordon, B. G. Firkin
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