Landmarking 2.0: Bridging the gap between joint models and landmarking [PDF]
The problem of dynamic prediction with time-dependent covariates, given by biomarkers, repeatedly measured over time, has received much attention over the last decades. Two contrasting approaches have become in widespread use. The first is joint modelling, which attempts to jointly model the longitudinal markers and the event time.
arxiv
Hepatic encephalopathy is a fatal complication of both chronic liver disease and acute hepatocellular failure. Usually, in such cases, the disease has a rapid progression and fatal prognosis.
Atanu Chandra, Indranil Sen
doaj +1 more source
Mathematical modelling indicates that lower activity of the haemostatic system in neonates is primarily due to lower prothrombin concentration [PDF]
Haemostasis is governed by a highly complex system of interacting proteins. Due to the central role of thrombin, thrombin generation and specifically the thrombin generation curve (TGC) is commonly used as an indicator of haemostatic activity. Functional characteristics of the haemostatic system in neonates and children are significantly different ...
arxiv +1 more source
MD simulations and experiments of plasma proteins adsorption to the biodegradable magnesium alloys to facilitate cell response [PDF]
Once the magnesium alloy was implanted in the body, it was immediately covered with plasma proteins. The coated alloy surface promoted the adsorption and growth of osteoblasts. Herein, in vitro biological reactions of the ZK60 and AZ31 magnesium alloys were analyzed with and without plasma proteins incubation.
arxiv
OBJECTIVES Edoxaban, an oral direct factor Xa inhibitor, does not require routine monitoring. However, assessment of the anticoagulant effects may be required in certain situations.
Y. Morishima, Chikako Kamisato
semanticscholar +1 more source
Background A substantial fraction of all American healthcare expenditures are potentially wasted, and practices that are not evidence-based could contribute to such waste.
Manu N. Capoor+17 more
semanticscholar +1 more source
Prothrombin Time, an Indicator for Psoriasis Activity: A Case - Control Study
Background: Psoriasis is a common chronic and recurrent inflammatory skin disorder related to the immune system and characterized by the rapid growth of skin cells.
Majid Morovati-Sharifabad+2 more
doaj
Study of Basic Coagulation Parameters among HIV Patients in Correlation to CD4 Counts and Art Status [PDF]
Introduction: HIV infection is known to cause coagulation abnormalities by various mechanism, especially during its late course. Aim: The objective of this study is to analyse platelet count, prothrombin time and activated partial thromboplastin time
R Thulasi Raman+5 more
doaj +1 more source
Development of a Machine Learning Model and Mobile Application to Aid in Predicting Dosage of Vitamin K Antagonists Among Indian Patients [PDF]
Patients who undergo mechanical heart valve replacements or have conditions like Atrial Fibrillation have to take Vitamin K Antagonists (VKA) drugs to prevent coagulation of blood. These drugs have narrow therapeutic range and need to be very closely monitored due to life threatening side effects.
arxiv
An Efficient Explicit-time Description Method for Timed Model Checking [PDF]
Timed model checking, the method to formally verify real-time systems, is attracting increasing attention from both the model checking community and the real-time community. Explicit-time description methods verify real-time systems using general model constructs found in standard un-timed model checkers.
arxiv +1 more source