Results 41 to 50 of about 17,100,037 (350)

Potential clinical benefits of warfarin in end‐stage cancers: A retrospective analysis

Health Science Reports, 2023
Background and Aims Coagulopathy and thromboembolism are common comorbidities in cancer, and anticoagulants, such as warfarin, are needed in specific situations. This study aimed to determine the clinical relevance of prothrombin time (PT) monitoring and
Osamu Imataki, Takeshi Arai, Makiko Uemura   +2 more
doaj   +1 more source

Bioinspired Smart Nanogels for Rapid Blue Laser‐Activated Hemostasis in Gastrointestinal Bleeding

Advanced Materials, EarlyView.
Waxberry‐inspired branched‐silica nanogel can swiftly stop bleeding upon blue laser endoscopy for gastrointestinal hemostasis in the esophagus, stomach, and duodenum of mini‐pigs. Abstract Gastrointestinal bleeding (GIB) is a critical condition that requires rapid and effective intervention.
Ruijue Dan, Yu Huang, Shali Tan, Kaige Xu, Yuchen Zhang, Zhaohui Luan, Paipai Qi, Xingyue Zhang, Donghui Zhu, Wen Zhong, Chaoqiang Fan, Malcolm Xing, Shiming Yang   +12 more
wiley   +1 more source

Association between PT, PT-INR, and in-hospital mortality in critically ill patients with tumors: A retrospective cohort study

Frontiers in Public Health, 2023
ObjectivesProthrombin time (PT) and PT-INR are independent predictors of mortality in patients with cancer. The PT and PT-INR of cancer patients are independent predictive variables of mortality.
Jia-Dong Liang, Zuo-An Qin, Jin-Hao Yang, Chao-Fen Zhao, Chao-Fen Zhao, Chao-Fen Zhao, Qian-Yong He, Qian-Yong He, Qian-Yong He, Kai Shang, Yu-Xin Li, Xin-Yu Xu, Yan Wang   +12 more
doaj   +1 more source

Deciphering the Role and Mechanism of Decidual Monocyte‐Derived Macrophage Infiltration in Obstetric Antiphospholipid Syndrome at Single‐Cell Resolution

Advanced Science, EarlyView.
This study uncovers a novel mechanism and therapeutic targets in obstetric antiphospholipid syndrome (OAPS). Antiphospholipid antibody/ß2‐glycoprotein I complex boosts CCL2 and TNF‐α expression in decidual macrophages via TLR4‐NF‐κB. CCL2 accumulates on endothelial surfaces via ACKR1, recruiting monocyte‐derived CCR2+ macrophages, driving inflammation,
Rui Gao, Pingying Qing, Hanxiao Chen, Zhengyan Hu, Qiaoran Yang, Chenyang Lu, Huimin Liu, Rujun Zeng, Yuanting Tang, Fan Yu, Jinbiao Han, Xin Liao, Xun Zeng, Lang Qin   +13 more
wiley   +1 more source

Effects of Verapamil and Diltiazem on the Pharmacokinetics and Pharmacodynamics of Rivaroxaban

Pharmaceutics, 2019
Concomitant use of rivaroxaban with non-dihydropyridine calcium channel blockers (non-DHPs) might lead to an increase of systemic rivaroxaban exposure and anticoagulant effects in relation to the inhibition of metabolic enzymes and/or transporters by non-
Minsoo Kim, Heebin Son, Keumhan Noh, Eunyoung Kim, Beom Soo Shin, Wonku Kang   +5 more
doaj   +1 more source

Polydopamine Nanodots Ameliorate Inflammatory Bowel Disease by Restoring Redox Homeostasis and Intestinal Microenvironment

Advanced Science, EarlyView.
A novel melanin‐based therapeutic composed of ultrasmall polydopamine nanodots is employed as an efficient oral formulation for the targeted treatment of inflammatory bowel disease. The potential therapeutic mechanism of polydopamine nanodots mainly involves the elimination of excessive oxidative stress, the reduction of ROS‐mediated proinflammatory ...
Zhen Ding, Xingfu Bao, Ying Zhao, Lin Bai, Jinming Zhang, Chengjing Xu, Tianyan Chen, Shuang Dai, Yufu Liu, Min Hu, Meng Qin, Zhen Liu   +11 more
wiley   +1 more source

Quick or Owren prothrombin time methods: possibilities and limitations (literature review)

Медицина неотложных состояний
Background. To treat patients with hypocoagulation, an objective assessment of the hemostasis system is mandatory. Owren prothrombin time method is rare in Ukrainian hospitals.
R.A. Zatsarynnyi, O.Yu. Khomenko, Y.A. Stadnik, K.S. Smirnova, J. Ptasekas   +4 more
doaj   +1 more source

Modulation of Aging Diseases via RAGE Targets: A Dietary Intervention Review

Advanced Science, EarlyView.
This paper analyzes RAGE ligand‐binding mechanisms and signaling, proposing intervention strategies targeting these interactions. It emphasizes dietary polyphenols, polysaccharides, and terpenoids delivered via functional foods for anti‐aging. These compounds offer long‐term, safe intervention through dietary supplementation, providing dual nutritional
Qian Wu, Jia Yan, Yuyan Zhang, Xiaozhi Ming, Siqi Chen, Zhichao Zou, Nianjie Feng, Jianbo Xiao   +7 more
wiley   +1 more source

Prothrombin time in retinitis pigmentosa

Indian Journal of Ophthalmology, 1998
The prothrombin time was recorded for 87 primary retinitis pigmentosa (RP) patients belonging to three different clinical categories. All categories showed prothrombin time higher than normal.
Vinchurkar Manisha
doaj  

Oral contraceptives and the prothrombin time. [PDF]

BMJ, 1980
PIP: Dr. De Teresa and others reported that mean prothrombin time ratio of 12 patients on long-term anticoagulation with warfarin was significantly higher when they were also taking oral contraceptives (OCs). A study of prothrombin complex activity was recently conducted in female rats treated with an estrogen-progestogen combination (lynestrenol 5 mg;
Maria Benedetta Donati, Maria Carla Roncaglioni, J Pangrazzi   +2 more
openaire   +2 more sources