Results 121 to 130 of about 14,853 (233)

Programmable RNA N6,2´‐O‐Dimethyladenosine Editing

Advanced Science, EarlyView.
ABSTRACT N6,2’‐O‐dimethyladenosine (m6Am) is a prevalent RNA modification located at the first transcribed nucleotide adjacent to the 5′ cap of mRNAs, where it has been implicated in gene regulation. However, the lack of methods for precise, transcript‐specific manipulation of m6Am has limited its functional dissection.
Yang Li, Xiangmin Tan, Yaran Liu, Yongquan He, Bo Yuan, Ping Wang, Guangzhi Ma, Mengzhe Guo, Jian Zhou, Qiang Sun   +9 more
wiley   +1 more source

A remarkable year for NSCLC: Seven new FDA approvals in 2025 across molecular targets. [PDF]

Biomol Biomed
Tomić K, Vranić S.
europepmc   +1 more source

PRMT5/Sohlh2/Sirt1 Signaling Pathway in Vascular Endothelial Cells Modulates Lung Metastasis of Triple‐Negative Breast Cancer

Advanced Science, EarlyView.
The cover image shows that vascular endothelial cells play an important role in lung metastasis of TNBC. Endothelial Sohlh2 acts as a gatekeeper against TNBC lung metastasis by limiting endothelial activation and tumor cell passage. PRMT5 reduces Sohlh2 stability, weakening this protective barrier.
Ruihong Zhang, Fengqin Wang, Lanlan Liu, Qi Zhang, Xiaoning Huo, Yanhui Nan, Yanli Dong, Yunling Xiao, Jing Hao   +8 more
wiley   +1 more source

Prediction of Proto-Oncogene Using Bidirectional GRU and Attention. [PDF]

Asian Pac J Cancer Prev
R D S, A BR.
europepmc   +1 more source

Boosting Sensory Nerve‐to‐Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair

Advanced Science, EarlyView.
Boosting sensory nerve activity via TrkA agonism strongly accelerates calvarial bone repair in adult mice. Furthermore, single‐cell RNA sequencing and neuron–bone interactome analyses identify these sensory neurons as a direct neural source of Hedgehog pathway ligands. Consequently, these ligands drive osteoblast differentiation of skeletal progenitors,
Zhao Li, Xin Xing, Beicheng Du, Myles Zhou, Austin Z. Chen, Mary Archer, Chunbao Rao, Manyu Zhu, Masnsen Cherief, Aaron W. James   +9 more
wiley   +1 more source

Medullary thyroid carcinoma exclusively associated with a homozygous RET V778I pathogenic variant: a case report with review of literature. [PDF]

Endocr J
Kihara M, Miyauchi A, Akamizu T.
europepmc   +1 more source

The role of Herceptin in early breast cancer [PDF]

, 2008
Ashok Subramanian, Kefah Mokbel, S Nicholson, SS Bacus, CI Bargmann, AL Schechter, T Yamamoto, S Burden, R Pinkas-Kramarski, PP di Fiore, PP di Fiore, RM Hudziak, F Lonardo, T Akiyama, DJ Slamon, DJ Slamon, DJ Slamon, I Stancovski, M Giai, M Guerin, DC Allred, E Liu, K Mokbel, S Masood, MA Cobleigh, RL Ridolfi, MP Hoang, RD Mass, c Falo, JMS Bartlett, D Gancberg, A Jones, LD Read, RJ Pietras, S Antoniotti, CC Benz, RJ Pietras, S Kato, G Bunone, YL Chung, H Lee, MJ Ellis, S Nicholson, C Wright, SJ Houston, C Carlomagno, De Laurentiis, S Sjogren, M Dowsett, AR Bianco, JC Hu, S Sjogren, SM Ali, IM Harwerth, IM Harwerth, RM Hudziak, LM Witters, H Kunisue, C Vogel, MA Cobleigh, M Dowsett   +60 more
core   +1 more source

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

Advanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang, Chenyu Deng, Zhengrong Gao, Chen Chen, Huimin Zheng, Yue Yang, Yan Wei   +6 more
wiley   +1 more source

Angiotensin-(1-7) Alleviates Isoproterenol-Induced Cardiac Hypertrophy by Suppressing Autophagy and Apoptosis Through the Synergistic Action of Mas Receptor and Angiotensin II Type 2 Receptor. [PDF]

Acta Physiol (Oxf)
Wang X, Guo F, Wang X, Guo Y, Fan S, Hong L, Jin H.   +6 more
europepmc   +1 more source

Prognostic Significance of Portal Vein Tumor Thrombus in Pancreatic Ductal Adenocarcinoma Treated With Chemoradiotherapy

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Aim To examine the significance of portal vein tumor thrombus (PVTT) as a prognostic factor for patients with pancreatic ductal adenocarcinoma (PDAC) treated with chemoradiotherapy (CRT) followed by surgery. Methods The study retrospectively examined 313 patients with borderline resectable (BR) or locally advanced (LA) PDAC who underwent CRT ...
Aoi Hayasaki, Motonori Nagata, Miki Usui, Hiroshi Imai, Yusuke Iizawa, Akihiro Tanemura, Yasuhiro Murata, Naohisa Kuriyama, Masashi Kishiwada, Shugo Mizuno   +9 more
wiley   +1 more source