Results 141 to 150 of about 1,121,649 (218)

Hepatic SNHG9 links gut microbiota to liver protection in drug-induced liver injury. [PDF]

Nat Commun
Bao W, Hang B, Zeng D, Mao J, Pan LB, Wang L, Xu G, Wang M, Liu K, Chen X, Zhu X, Li G, Xu D, Li G, Ding Y, Liang Q, Dou X, Xu W, Chen J, Pan J, Lu Y, Wang Y.   +21 more
europepmc   +1 more source

Plant Virus Immunotherapy for HPV‐Associated Oropharyngeal Squamous Cell Carcinoma

Advanced NanoBiomed Research, EarlyView.
Cowpea mosaic virus (CPMV) nanoparticles are safe and potent cancer immunotherapy candidates with strong immunomodulatory activity. CPMV activates innate immunity, which in turn drives adaptive immune responses and promotes durable, systemic antitumor effects.
Jessica Fernanda Affonso de Oliveira, Patrick Opdensteinen, Andrea Simms, Seongwon Jung, Giuliana P. Mognol, Hui Chen, Judith A. Varner, Nicole F. Steinmetz   +7 more
wiley   +1 more source

Renin-angiotensin imbalance promotes excessive fibrin deposition through M2 macrophage-derived tissue factor expression in eosinophilic chronic rhinosinusitis. [PDF]

Inflamm Res
Takabayashi T, Yoshida K, Kato Y, Sakashita M, Fujieda S.   +4 more
europepmc   +1 more source

Mas Knockout Mice Present Altered Behavioral and Neuroendocrine Coping Responses to Chronic Unpredictable Stress. [PDF]

Mol Neurobiol
Gonçalves SCA, da Silveira Silva A, Nogueira BKO, Mourão FAG, Fontes MAP, Bader M, Santos RAS, Campagnole-Santos MJ, Kangussu LM.   +8 more
europepmc   +1 more source

Differential Water Networks Guide Selectivity Optimization of a Cell Active BPTF Inhibitor in Neuroblastoma

Angewandte Chemie International Edition, EarlyView.
BZ2 is a second‐generation Bromodomain PHD finger Transcription Factor (BPTF) inhibitor with improved selectivity over Class I and Class IV BRD off‐targets identified in our previously reported inhibitor, BZ1. Structural analyses reveal that water network engagement is key to this selectivity.
Kesavan Babu, Chun‐Ju Tsou, Sourav Das, Liying Fan, Anasuya Pal, Molly Sneddon, Timothy R. Stachowski, Priyanka Samanta, Stanley Nithianantham, Caroline Buchholz, Shi Zhang, Xiang Fu, Rahul S. Kathayat, Wenwei Lin, Yongtao Li, Lei Yang, Taosheng Chen, Marcus Fischer, Anang A. Shelat, William C. K. Pomerantz   +19 more
wiley   +1 more source

La trasparenza nei rapporti banca-cliente

Analisi della regolamentazione relativa alla trasparenza bancaria: strumenti di pubblicità, forma e contenuto dei contratti, variazione unilaterale delle condizioni economiche, modalità di calcolo degli interessi e requisiti organizzativi, con ...
Proto Antonio
core  

Medullary thyroid carcinoma exclusively associated with a homozygous RET V778I pathogenic variant: a case report with review of literature. [PDF]

Endocr J
Kihara M, Miyauchi A, Akamizu T.
europepmc   +1 more source

Discovery of an Antiviral Electron Transfer Process to Create Catalytically Self‐Sufficient Viral Restriction Factors

Angewandte Chemie International Edition, EarlyView.
CYB5R3 is identified as a putative electron‐transfer partner of viperin (RSAD2), explaining why ER localisation is required for antiviral activity. Its utilisation enabled the engineering of immune‐silent, catalytically self‐sufficient antiviral restriction factor enzymes (iCAREs) that produce an antiviral nucleoside triphosphate analogue (ANTA ...
Mengdi Wu, Nghi Thao Hoang, Deborah Grifagni, Meritxell Wu‐Lu, Yujie Sheng, Theo Situmorang, Pei‐Hsin Tai, Zheng Chen, Astrid Maluta, Mohammed Hakil, Bianca Susini, Hannah Florance, Peter‐Leon Hagedoorn, John Mark Sutton, Maria‐Andrea Mroginski, Simone Ciofi‐Baffoni, Kourosh H. Ebrahimi   +16 more
wiley   +1 more source

GiGCN: a network-based framework for uncovering synthetic lethal and viable genetic interactions. [PDF]

Brief Bioinform
Wang Q, Yang F, Fu M, Huo Y, Wang J.
europepmc   +1 more source

A computational analysis of multi-target mechanisms linking bisphenol A to precocious puberty. [PDF]

PeerJ
Zhang J, Zhu J, Wu Y, Zhou H, Zhang Z.
europepmc   +1 more source