Results 141 to 150 of about 14,853 (233)

miR-221/222 Facilitate Pituitary Adenoma Progression Via PHACTR4 Downregulation. [PDF]

Hum Mutat
Dong W, Yan S, Song L, Wang W, Sun D, Pang P, Yang G, Gu W, Nair S.   +8 more
europepmc   +1 more source

Molecular characterization of the A52 murine hepatocellular carcinoma cell line

Animal Models and Experimental Medicine, EarlyView.
Hepatocellular carcinoma (HCC) is a poor outcome cancer with limited therapeutic choices. To advance therapeutic development we genetically characterized the A52 murine HCC cell line. We noted genetic changes that match a subset of human HCC and this offers the opportunity to test novel targeted therapies in syngeneic mice.
Rhys Gillman, Eun Jin Sun, Miriam Wankell, Matt A. Field, Ulf Schmitz, Lionel Hebbard   +5 more
wiley   +1 more source

Proliferation and apoptosis in proliferative lesions of the colon and rectum [PDF]

, 1997
Bosman, F.T.B. (Fré), Dinjens, W.N.M. (Winand), Kikuchi, Y. (Youichi)   +2 more
core   +9 more sources

Clinical Significance and Potential Molecular Mechanisms of Angiotensin-Converting Enzyme 2 in Colorectal Cancer. [PDF]

World J Oncol
Zeng DT, Yang L, Wen JY, Wu KJ, Chen GQ, Li ZY, Ling JW, Huang BB, Xie YY, Dong YY, Fang YY, Wei DM, Chen G, Shi L, Huang WJ.   +14 more
europepmc   +1 more source

Equine models in translational medicine: A comparative approach to human health

Animal Models and Experimental Medicine, EarlyView.
This diagram summarizes and contrasts rodent and equine models, outlining their strengths, limitations, and applications. Horses offer naturally occurring diseases, genetic and physiological similarities to humans, and suitability for longitudinal and clinical‐scale studies.
Shayan Boozarjomehri Amnieh, Katarzyna Ropka‐Molik   +1 more
wiley   +1 more source

Mutation of rearranged during transfection (RET) is associated with enhanced tumor immunogenicity and favorable outcomes in pan-cancer immunotherapy. [PDF]

Oncologist
Cai J, Huang Z, Li Y, Zhou J, Xu Y, Cai M, Zhao H, Zhao B.   +7 more
europepmc   +1 more source

Transcriptomic validation of a 7,12 Dimethylbenz(a)anthracene (DMBA)‐induced leukemia rat model: Parallels with human leukemogenesis

Animal Models and Experimental Medicine, EarlyView.
7,12‐Dimethylbenz[a]anthracene (DMBA) could induce leukemia and other types of cancers in rat models. Transcriptomics revealed gene expression profile that parallels with human leukemia. DMBA‐induced differential gene expression could validate the developed rat model.
Khaldoon Alsamman, Omar S. El‐Masry
wiley   +1 more source

Encorafenib plus binimetinib versus dabrafenib plus trametinib for the first-line treatment of patients with BRAF^V600E-mutant metastatic non-small cell lung cancer: a matching-adjusted indirect treatment comparison. [PDF]

ESMO Open
Planchard D, Mazières J, Grouin JM, Le Reun C, Luttenauer H, Boussahoua M, Macabeo B.   +6 more
europepmc   +1 more source

The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding

Animal Research and One Health, EarlyView.
A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang, Weiran Wu, Qingqing Cai, Jiaxing Wang, Qi Gao, Muhammad Iftikhar, Yulin Bi, Hao Bai, Lihong Gu, Guobin Chang, Shihao Chen   +10 more
wiley   +1 more source

A Pathogenic ROCK-Signaling Network Involving a Lysine Deletion in Myh11 Renders Carriers Susceptible to Aortic Dissection. [PDF]

Int J Mol Sci
Okuhata H, Tomida S, Ishima T, Nagai R, Aizawa K.   +4 more
europepmc   +1 more source