Results 141 to 150 of about 384,382 (347)

The role of radiotherapy in patients with advanced melanoma failing targeted therapy

Acta Oncologica
Background and purpose: Approximately 50% of patients with metastatic melanoma harbor mutations in the BRAF gene, making them eligible for targeted therapy (TT). However, treatment options become limited once resistance develops.
Ellen Heurlin, Lina Grödeberg, Hildur Helgadottir   +2 more
doaj   +1 more source

Src-homology domain 2 containing protein tyrosine phosphatase-1 (SHP-1) directly binds to proto-oncogene tyrosine-protein kinase Src (c-Src) and promotes the transcriptional activation of connexin 43 (Cx43) [PDF]

, 2022
Yihao Liu, Meng Dai, Penghui Yang, Li Cao, Lu Li   +4 more
openalex   +1 more source

Response : Sperm-Egg Binding Protein or Proto-Oncogene? [PDF]

Science, 1996
P, Saling, R, Carballada, D, Burks, H, Moore   +3 more
openaire   +2 more sources

Kelvin Probe Force Microscopy in Bionanotechnology: Current Advances and Future Perspectives

Advanced Materials, EarlyView.
Kelvin probe force microscopy (KPFM) enables the nanoscale mapping of electrostatic surface potentials. While widely applied in materials science, its use in biological systems remains emerging. This review presents recent advances in KPFM applied to biological samples and provides a critical perspective on current limitations and future directions for
Ehsan Rahimi, Mario Palacios‐Corella, Arjan Mol, Salvador Pané, Josep Puigmartí‐Luis   +4 more
wiley   +1 more source

A novel role for nonactin: interfering with G-quadruplex in RET-driven medullary thyroid cancer

BMC Cancer
Background Medullary Thyroid Carcinoma (MTC) is closely associated with mutations in the RET proto-oncogene, placing the activated RET protein at the center of MTC pathogenesis. Existing therapeutic solutions, primarily tyrosine kinase inhibitors such as
Tariq Alqahtani, Arwa Alsubait, Meshari Aloumi, Abdulrahman Alamer, Ghala Alomari, Osama I. Alwassil, Ahmad J. Obaidullah, Sahar S. Alghamdi   +7 more
doaj   +1 more source

Perfusion Bioreactor Culture Incorporating Mechanical Confinement Enhances Mesenchymal Stem Cell Extracellular Vesicle Production and Wound Healing Potential

Advanced Materials Technologies, EarlyView.
Scalable manufacturing challenges and limited potency remain two of the most intransigent issues limiting clinical translation of EV therapeutics. Mechanical cues can induce phenotypic changes and increased vesiculation in EV source cells without the use of extraneous reagents, chemicals, and/or cargo, thereby potentially drastically improving the ...
Emily H. Powsner, Raith Nowak, Stephanie M. Kronstadt, Nicholas H. Pirolli, Talia J. Solomon, Kristin Nikolov, William Pieper Holeman, Ian M. Smith, Kimberly M. Stroka, John P. Fisher, Steven M. Jay   +10 more
wiley   +1 more source

Proto-oncogene Protein Sequence Classification using RNN and CNN with Attention Mechanism

, 2023
Et al. M.Vijayalakshmia
openalex   +2 more sources

Prevalence of c-myc expression in breast lesions associated with microcalcifications detected by routine mammography

São Paulo Medical Journal
CONTEXT AND OBJECTIVE: Genetic abnormalities in cell proliferation-regulating genes have been described in premalignant lesions. The aims here were to evaluate c-myc protein expression in non-palpable breast lesions associated with microcalcifications ...
Renato Coimbra Mazzini, Simone Elias, Afonso Celso Pinto Nazário, Cláudio Kemp, Ângela Flávia Logullo   +4 more
doaj   +1 more source

ETS Proto-oncogene 1 Transcriptionally Up-regulates the Cholangiocyte Senescence-associated Protein Cyclin-dependent Kinase Inhibitor 2A [PDF]

, 2017
Steven P. O’Hara, Patrick L. Splinter, Christy E. Trussoni, María J. Lorenzo Pisarello, Lorena Loarca, Noah S. Splinter, Bryce F. Schutte, Nicholas F. LaRusso   +7 more
openalex   +1 more source

Engineering Osteoimmune Responses with Functionalized Orthopedic Implants for Post‐Operative Osteosarcoma Treatment

Advanced Science, EarlyView.
Osteosarcoma is the most common primary bone tumor with limited treatment options and a terrible prognosis. This review provides a comprehensive summary of the recent development of osteoimmunomodulatory implants for post‐operative osteosarcoma treatment, of which the potential utility in evoking durable anti‐osteosarcoma immunity and accelerating bone
Yilong Dong, Lingshuang Wang, Hui Zhang, Menghuan Li, Zhong Luo, Yan Hu, Chunyuan Cai   +6 more
wiley   +1 more source