Results 231 to 240 of about 384,382 (347)

Ret proto-oncogene (RET); KIF5B-RET oncogenic fusion protein [PDF]

Science-Business eXchange, 2012
openaire   +1 more source

Nuclear Mechanotransduction Across the Metastatic Cascade: Decoding Spatiotemporal Heterogeneity in Cancer Dissemination

Advanced Science, EarlyView.
Tumor metastasis results from complex interactions between cancer cells and mechanical microenvironments. We propose a “nucleus‐centered, cross‐stage mechanical signal decoding” model, highlighting how nuclear mechanosensors interpret forces at different stages.
Linqi Song, Jingyang Liu, Xue Wang, Minpu Zhang, Changgang Sun   +4 more
wiley   +1 more source

Rosa roxburghii Tratt. enhances fracture healing through multitarget regulation of osteogenesis and angiogenesis: Integrated network pharmacology and molecular docking analysis. [PDF]

Medicine (Baltimore)
Wu Z, Luo P, Liu H, Xu J, Ying Q, Zhang J, Xuan Z.   +6 more
europepmc   +1 more source

Copper Depletion Nanoparticles Potentiate Cancer Immunotherapy by Avoiding Innate and Adaptive Immune Resistance

Advanced Science, EarlyView.
A mitochondria‐targeted copper depletion nanoplatform (CYN‐CDA@Alb) was developed to selectively disrupt tumor mitochondria copper, which then reprogrammed the tumor immune microenvironment by depressing PD‐L1 and CD47 expression simultaneously. By doing this, CYN‐CDA@Alb reversed radiotherapy‐induced immune tolerance, showing the potential usage of ...
Zaigang Zhou, Ke Li, Xuelan Li, Lei Yi, Zhengxiang Wang, Huan Ding, Sheng Wu, Feiyu Liu, Yuan Li, Rui Cheng, Jianliang Shen   +10 more
wiley   +1 more source

Hsa_circ_0000437 promotes the progression of rheumatic valvular heart disease by activating the mitogen-activated protein kinase signaling pathways after sponging let-7f-5p and targeting RAS-like proto-oncogene B. [PDF]

Hum Cell
Zhu L, Li N, Shi H, Song J, Fang Z, Shen Q, Zhu X, Dan Y, Shao G, Sun L.   +9 more
europepmc   +1 more source

Cells Dynamically Adapt Their Nuclear Volumes and Proliferation Rates During Single to Multicellular Transitions

Advanced Science, EarlyView.
It is currently not well understood how cells regulate basic properties, e.g., volume and mechanics within dense multicellular environments like tumors. Here, we show that different cell types of cancer and also normal cells largely decrease their nuclear and cellular volumes in emerging cell clusters and that this is partly driven by cell cycle shifts.
Vaibhav Mahajan, Keshav Gajendra Babu, Markus Mukenhirn, Antje Garside, Vinita Ajit Kini, Trishla Adhikari, Timon Beck, Byung Ho Lee, Kyoohyun Kim, Carsten Werner, Raimund Schlüßler, Alf Honigmann, Sebastian Aland, Anna Verena Taubenberger   +13 more
wiley   +1 more source

Pleomorphic Carcinoma With EGFR and Concomitant Mutations Transformed From Lung Adenocarcinoma: A Case Report. [PDF]

Cancer Rep (Hoboken)
Akazawa Y, Sato T, Yagami Y, Kesen Y, Furo T, Watanabe A, Endo J, Nakano M, Kurata H, Matsuo H, Nakahara Y, Sasaki J, Naoki K.   +12 more
europepmc   +1 more source

Programmable RNA N6,2´‐O‐Dimethyladenosine Editing

Advanced Science, EarlyView.
ABSTRACT N6,2’‐O‐dimethyladenosine (m6Am) is a prevalent RNA modification located at the first transcribed nucleotide adjacent to the 5′ cap of mRNAs, where it has been implicated in gene regulation. However, the lack of methods for precise, transcript‐specific manipulation of m6Am has limited its functional dissection.
Yang Li, Xiangmin Tan, Yaran Liu, Yongquan He, Bo Yuan, Ping Wang, Guangzhi Ma, Mengzhe Guo, Jian Zhou, Qiang Sun   +9 more
wiley   +1 more source

B-Cell Lymphoma 2 Mitochondria-Mediated Apoptotic Pathway in Cervical Carcinoma. [PDF]

Maedica (Bucur)
Karahaliou C, Mastronikoli S, Tsiambas E, Fotiades P, Niotis A, Kyrousis G, Lazaris AC, Kavantzas N, Agrogiannis G.   +8 more
europepmc   +1 more source

Activation of the Erk8 Mitogen-activated Protein (MAP) Kinase by RET/PTC3, a Constitutively Active Form of the RET Proto-oncogene [PDF]

, 2006
Carlo Iavarone, Mario Acunzo, Francesca Carlomagno, Annunziata Catania, Rosa Marina Melillo, Stella M. Carlomagno, Massimo Santoro, M Chiariello   +7 more
openalex   +1 more source