Results 21 to 30 of about 197,127 (261)
Mouse Models as a Tool for Understanding Progression in Braf-Driven Thyroid Cancers [PDF]
Endocrinology and Metabolism, 2019 The development of next generation sequencing (NGS) has led to marked advancement of our understanding of genetic events mediating the initiation and progression of thyroid cancers. The NGS studies have confirmed the previously reported high frequency of
Iñigo Landa, Jeffrey A. Knauf
doaj +1 more source
Expression of Bcl-2-family proteins in peripheral blood B-lymphocytes in patients with cronic lymphocytic leukemia [PDF]
Vojnosanitetski Pregled, 2004 Chronic lymphocytic leukemia (CLL) is a neoplastic disease characterized by the accumulation of morphologically mature monoclonal CD 5+ B cells in the early phase (G0/G1) of the cell cycle.
Brajušković Goran R. +7 more
doaj +1 more source
Review papers The role of KIT gene mutations in pathogenesis of pediatric mastocytosis
Przegląd Dermatologiczny, 2015 Mastocytosis is characterized by excessive proliferation and accumulation of mast cells in skin and/or other organs. Two forms of the disease, cutaneous and systemic mastocytosis, differ significantly in symptomatology and clinical course.
Joanna Dawicka +5 more
doaj +1 more source
The proto-oncogene SRC phosphorylates cGAS to inhibit an antitumor immune response
JCI Insight, 2023 Cyclic GMP-AMP synthase (cGAS) is a DNA sensor and responsible for inducing an antitumor immune response. Recent studies reveal that cGAS is frequently inhibited in cancer, and therapeutic targets to promote antitumor cGAS function remain elusive. SRC is
William Dunker +5 more
doaj +1 more source
Anais Brasileiros de Dermatologia, 2023 Background: A lot of congenital melanocytic nevi (CMN) carry the somatic mutation in the oncogene BRAF V600E. But the detailed histopathologic characteristics and the proliferative activity of CMN with BRAF V600E gene mutation have not been ...
Jianyou Chen +3 more
doaj +1 more source
No detection of c-kit gene mutations in exons 9, 11, 13 and 17 and low CD117 expression in plaque-stage mycosis fungoides [PDF]
Anais Brasileiros de Dermatologia, 2018 : The growth factor receptor c-kit (CD117) is expressed in immature T-cells and in some advanced forms of mycosis fungoides. c-kit gene mutation results in unrestricted neoplastic proliferation.
David Aldo De Luca +3 more
doaj +1 more source
Dependence of protein-induced lipid bilayer deformations on protein shape [PDF]
, 2022 Membrane proteins typically deform the surrounding lipid bilayer membrane, which can play an important role in the function, regulation, and organization of membrane proteins. Membrane elasticity theory provides a beautiful description of protein-induced lipid bilayer deformations, in which all physical parameters can be directly determined from ...
arxiv +1 more source
OncoTarget, 2017 Competing endogenous RNA (ceRNA) is a newly proposed mechanism that describes a crosstalk among lncRNAs, mRNAs and their shared miRNAs. In this study, the role of miR-338-3p (miR-338) in the progression of esophageal cancer and its involve in the ceRNA ...
Yan Yan +5 more
semanticscholar +1 more source
Primary colonic liposarcomatosis: report of a case with review of literature
Autopsy and Case Reports, 2019 LiposarcomaThe colon is a rare site of occurrence of liposarcoma, as either the primary site or by secondary involvement from a retroperitoneal liposarcoma. Liposarcomatosis denotes simultaneous occurrence of multiple liposarcomas.
Mahesh Sultania +4 more
doaj +1 more source
Evaluation of the relationship between c-Kit expression and mean platelet volume in classic Kaposi's sarcoma [PDF]
Anais Brasileiros de Dermatologia, 2016 : Background: c-Kit is a proto-oncogene that encodes tyrosine kinase receptor (CD117). Mean platelet volume (MPV) is a useful marker, providing information on platelet function and diameter.
Ibrahim Sehitoglu +5 more
doaj +1 more source