Results 111 to 120 of about 44,162 (208)

Mitosis, Cytoskeleton Regulation, and Drug Resistance in Receptor Triple Negative Breast Cancer [PDF]

arXiv
During cell division, the receptor triple-negative MDA-MB-231 mitotic spindles are the largest in comparison to other BC cell lines. Many of the MDA-MB-231 spindles exhibit rapid lateral twisting during metaphase, which remains unaffected by knockdown of the oncogene Myc and treatment with inhibitors of the serine/threonine-protein kinase B-Raf and the
arxiv  

Molecular and functional profiling unravels targetable vulnerabilities in colorectal cancer

Molecular Oncology, Volume 19, Issue 6, Page 1751-1774, June 2025.
We used whole exome and RNA‐sequencing to profile divergent genomic and transcriptomic landscapes of microsatellite stable (MSS) and microsatellite instable (MSI) colorectal cancer. Alterations were classified using a computational score for integrative cancer variant annotation and prioritization.
Efstathios‐Iason Vlachavas, Konstantinos Voutetakis, Vivian Kosmidou, Spyridon Tsikalakis, Spyridon Roditis, Konstantinos Pateas, Ryangguk Kim, Kymberleigh Pagel, Stephan Wolf, Gregor Warsow, Antonia Dimitrakopoulou‐Strauss, Georgios N. Zografos, Alexander Pintzas, Johannes Betge, Olga Papadodima, Stefan Wiemann   +15 more
wiley   +1 more source

A Preliminary Work on Evolutionary Identification of Protein Variants and New Proteins on Grids [PDF]

Dans AINA 2006, HIPCOMB Workshop (2006), 2008
Protein identification is one of the major task of Proteomics researchers. Protein identification could be resumed by searching the best match between an experimental mass spectrum and proteins from a database. Nevertheless this approach can not be used to identify new proteins or protein variants.
arxiv  

Understanding Functional Protein-Protein Interactions Of ABCB11 And ADA In Human And Mouse [PDF]

arXiv, 2015
Proteins are macromolecules which hardly act alone; they need to make interactions with some other proteins to do so. Numerous factors are there which can regulate the interactions between proteins [4]. Here in this present study we aim to understand Protein -Protein Interactions (PPIs) of two proteins ABCB11 and ADA from quantitative point of view ...
arxiv  

The biological function of the proto-oncogene Cot/tpl-2 [PDF]

, 2013
Capítulo 2.-- Editor: Pedro A. Lazo.Cot, as well as its murine homologue tpl-2, was discovered in a COOH–terminal truncated form that unmasks the transformation capacity of the protein.
Alemany, Susana, Fernández, Margarita, López-Peláez, Marta, Martín-Duce, Antonio, Soria-Castro, Irene   +4 more
core  

Angio‐associated migratory cell protein promotes colorectal cancer progression by enhancing phosphoglycerate kinase 1 phosphorylation

Journal of Cell Communication and Signaling, Volume 19, Issue 2, June 2025.
AAMP promotes CRC progression by enhancing the p‐PGK1, highlighting its novel role in CRC. Abstract To elucidate the oncogenic role of angio‐associated migratory cell protein (AAMP) in colorectal cancer (CRC) and its mechanistic interplay with phosphoglycerate kinase 1 (PGK1).
Wei Zhang, Qian Shi, Qincheng Liu, Haomiao Zhang, Ji Xia, Xueli Zhang   +5 more
wiley   +1 more source

Mutação BRAF em pacientes idosos submetidos à tireoidectomia BRAF mutation in the elderly submitted to thyroidectomy

Revista do Colégio Brasileiro de Cirurgiões, 2013
OBJETIVO: Avaliar a frequência da mutação V600E do gene BRAF em pacientes com mais de 65 anos de idade submetidos à tireoidectomia, correlacionando sua presença ou ausência com as diferentes lesões histológicas, com as variantes e com fatores ...
Antonio Augusto T. Bertelli, Antonio José Gonçalves, Marcelo B. Menezes, Murilo R. Melo, Stefano Tincani, Luiz Cláudio Bosco Massarollo   +5 more
doaj  

HSEARCH: fast and accurate protein sequence motif search and clustering [PDF]

arXiv, 2017
Protein motifs are conserved fragments occurred frequently in protein sequences. They have significant functions, such as active site of an enzyme. Search and clustering protein sequence motifs are computational intensive. Most existing methods are not fast enough to analyze large data sets for motif finding or achieve low accuracy for motif clustering.
arxiv  

Selenium Nanoparticles in Cancer Therapy: Unveiling Cytotoxic Mechanisms and Therapeutic Potential

Cancer Reports, Volume 8, Issue 6, June 2025.
ABSTRACT Background Cancer represents a complex group of diseases characterized by abnormal cell proliferation, invasion, and metastasis. These features pose significant challenges to conventional therapeutic approaches, necessitating the development of more targeted and effective treatment strategies.
Sumaira Anjum, Mariam Hashim, Maham Imran, Sundus Babur, Sanniah Adnan, Christophe Hano, Wisam Nabeel Ibrahim   +6 more
wiley   +1 more source

Neutrophil extracellular traps in cancer: From mechanisms to treatments

Clinical and Translational Medicine, Volume 15, Issue 6, June 2025.
Neutrophil extracellular traps are intricately linked to the tumor microenvironment and play a crucial role in tumorigenesis, metastasis, and related complications. Consequently, NETs‐based tumor biomarkers and therapeutic strategies warrant significant attention.
Yifan Wang, Kangjie Yang, Juan Li, Chuanxin Wang, Peilong Li, Lutao Du   +5 more
wiley   +1 more source