Results 51 to 60 of about 49,863 (128)
Health Services Research, EarlyView.ABSTRACT Objective To determine the effectiveness and cost‐effectiveness of multi‐gene panel sequencing compared to single‐gene KRAS testing for metastatic colorectal cancer (mCRC). Study Setting and Design British Columbia, Canada (BC) is a provincial single‐payer public healthcare system, and it was the first province to publicly reimburse multi‐gene
Emanuel Krebs +4 more
wiley +1 more source
Synovial fibroblasts: key players in rheumatoid arthritis [PDF]
, 2017 Rheumatoid arthritis (RA) is a chronic autoimmune-disease of unknown origin that primarily affects the joints and ultimately leads to their destruction. The involvement of immune cells is a general hallmark of autoimmune-related disorders. In this regard,
Distler, O. +5 more
core
Decoding RAS isoform and codon-specific signalling [PDF]
, 2014 RAS proteins are key signalling hubs that are oncogenically mutated in 30% of all cancer cases. Three genes encode almost identical isoforms that are ubiquitously expressed, but are not functionally redundant.
Coulson, Judy M +3 more
core +1 more source
British Journal of Pharmacology, EarlyView.Addressing complexity in the study of life sciences through Systems Biology and Systems Medicine has been transformative, making Systems Pharmacology the next logical step. In this review, we focus on physical stimuli, whose potential in pharmacology has been neglected, despite demonstrated therapeutic properties.
Veronica Paparozzi +10 more
wiley +1 more source
From mechanism to phenotype: What fits in a basket trial
Epilepsia, EarlyView.
Kette D. Valente
wiley +1 more source
Opioids in breast cancer: Between analgesia and modulation of tumour progression
British Journal of Pharmacology, EarlyView.Preclinical investigations consistently demonstrate that activation of μ‐opioid receptors and δ‐opioid receptors promote proliferation, migration, angiogenesis, epithelial‐mesenchymal transition, acquisition of cancer stem cell phenotypes, and chemoresistance.
Marianna Ciwun +2 more
wiley +1 more source
BRAFV600 Mutationen sind ein negativer Prognosefaktor beim kolorektalen Karzinom, welches typischerweise resistent gegen BRAF-Inhibitoren ist. Etliche Resistenzmechanismen sind HSP90-abhängig, sodass eine Kombination von BRAF- und HSP90-Inhibition einen vielversprechenden Ansatz darstellt. Allerdings ist die Datenlage bislang ungenügend.
openaire +2 more sources
JDDG: Journal der Deutschen Dermatologischen Gesellschaft, EarlyView.Summary Background and Objectives Complete lymph node dissection (CLND) is the standard of care in patients with regional nodal melanoma macrometastasis. However, evidence on surgical procedures in the era of adjuvant systemic therapies is lacking. Patients and Methods This retrospective multi‐center study included stage IIIB–D melanoma patients with ...
Kristine E. Mayer +13 more
wiley +1 more source
Regulation of pyruvate dehydrogenase complex: Dancing to different drums in cancer
International Journal of Cancer, Volume 158, Issue 6, Page 1464-1480, 15 March 2026.Abstract Mechanisms governing the regulation of pyruvate dehydrogenase complex (PDC) are markedly modified in cancer cells compared to normal cells. PDC activity in normal cells is controlled by the reversible phosphorylation of three serine residues by dedicated kinases and phosphatases.
Mulchand S. Patel, Todd C. Rideout
wiley +1 more source
Extramedullary Disease—Achilles Heel in Myeloma?
American Journal of Hematology, Volume 101, Issue 3, Page 521-536, March 2026.ABSTRACT Despite advances in therapy, extramedullary disease (EMD) remains an aggressive form of multiple myeloma associated with poor outcomes. Patients with true EMD, in which plasmacytomas have become completely independent of bone, have a particularly poor prognosis. The pathogenesis of EMD is driven by complex mechanisms involving loss of adhesion
Shaji Kumar +7 more
wiley +1 more source