Results 141 to 150 of about 60,057 (198)

Oxidative Stress in Antigen Processing and Presentation

MedComm – Oncology, Volume 4, Issue 2, June 2025.
Reactive oxygen species (ROS) play a crucial role in antigen processing and presentation, essential for linking innate and adaptive immunity. While balanced ROS levels promote immune function, excess ROS can disrupt antigen recognition, resulting in immune dysfunction.
Qinxia Chang, Yaying Zhang, Xiaojun Liu, Peng Miao, Wenbing Pu, Shanshan Liu, Jing Zhang, Yuan Tian, Guobo Shen, Na Xie   +9 more
wiley   +1 more source

Development of a Short Telomere Zebrafish Model for Accelerated Aging Research and Antiaging Drug Screening

Aging Cell, Volume 24, Issue 6, June 2025.
Larvae derived from a cross between tert deficient and haploinsufficient fish show a premature aging phenotype, characterized by telomere attrition and early death. The ST2 larval model is a valuable tool for rapid screening of antiaging molecules. Given that organogenesis occurs within the first 48 h, this model also allows for the conduction of aging
David Hernández‐Silva, María D. López‐Abellán, Francisco J. Martínez‐Navarro, Jesús García‐Castillo, María L. Cayuela, Francisca Alcaraz‐Pérez   +5 more
wiley   +1 more source

An optimised Bcl‐3 inhibitor for melanoma treatment

British Journal of Pharmacology, Volume 182, Issue 11, Page 2426-2446, June 2025.
Abstract Background and Purpose Malignant melanoma is the most lethal form of skin cancer, characterised by a poor survival rate. One of the key factors driving the aggressive growth of melanoma cells is the elevated expression of the proto‐oncogene Bcl‐3. This study aims to optimise, evaluate and characterise a second‐generation Bcl‐3 inhibitor, using
Karunakar Saamarthy, Renée Daams, Wondossen Sime, Cecilia Persson, Eduard Chygorin, Kristofer Ahlqvist, Susan Evans‐Axelsson, Daniel Strand, Ramin Massoumi   +8 more
wiley   +1 more source

Epacadostat Overcomes Cetuximab Resistance in Colorectal Cancer by Targeting IDO‐Mediated Tryptophan Metabolism

Cancer Science, Volume 116, Issue 6, Page 1715-1729, June 2025.
The effect of cetuximab and epacadostat combinative therapy on CRC cells. ABSTRACT Primary or acquired mutations in RAS/RAF genes resulting in cetuximab resistance have limited its clinical application in colorectal cancer (CRC) patients. The mechanism of this resistance remains unclear.
Yimin Zhou, Qiongyan Tao, Chubin Luo, Jinsong Chen, Genwen Chen, Jianyong Sun   +5 more
wiley   +1 more source

MIB2‐Mediated SUZ12 Ubiquitination Regulates Clonal Proliferation in Patients With Paroxysmal Nocturnal Haemoglobinuria

Journal of Cellular and Molecular Medicine, Volume 29, Issue 11, June 2025.
ABSTRACT Secondary gene mutations are one of the main mechanisms underlying paroxysmal nocturnal haemoglobinuria (PNH) clone proliferation. Our previous studies showed that SUZ12 participates in PNH clone proliferation by regulating H3K27me3. However, the mechanism underlying the SUZ12 function remains unclear. Immunoprecipitation and mass spectrometry
Hui Liu, Lijie Zeng, Chaomeng Wang, Yingying Chen, Liyan Li, Zhaoyun Liu, Honglei Wang, Rong Fu   +7 more
wiley   +1 more source

The Efficacy of Hellebrigenin Against Nasopharyngeal Carcinoma Cells: The Molecular and Bioinformatic Analysis

Journal of Cellular and Molecular Medicine, Volume 29, Issue 11, June 2025.
ABSTRACT Nasopharyngeal carcinoma (NPC) is a unique cancer type originating from the nasopharynx. To investigate novel strategies for improving prognosis and reducing the adverse effects of current treatments, this study examined the efficacy of hellebrigenin.
Hsin‐Yu Ho, Mu‐Kuan Chen, Yun‐Jung Tsai, Chia‐Chieh Lin, Yu‐Sheng Lo, Yi‐Ching Chuang, Ming‐Ju Hsieh   +6 more
wiley   +1 more source

Dual Targeting EZH2 and Histone Deacetylases in Human Uterine Sarcoma Cells Under Both 2D and 3D Culture Conditions

Journal of Cellular and Molecular Medicine, Volume 29, Issue 11, June 2025.
ABSTRACT Uterine sarcoma is strongly associated with poor prognosis. However, its treatment options remain limited. Tazemetostat is a potent and selective EZH2 inhibitor with limited clinical application. Entinostat is one of the strong inhibitors for HDAC1 and HDAC3.
Mervat M. Omran, Somayeh Vafaei, Samar Alkhrait, Qiwei Yang, Ayman Al‐Hendy   +4 more
wiley   +1 more source

LncRNA SNHG14 Regulated by ZNF460 Promotes Gastric Cancer Progression and Metastasis by Targeting the miR‐206/FNDC3A Axis

Journal of Cellular and Molecular Medicine, Volume 29, Issue 11, June 2025.
ABSTRACT The current study investigated the functional role of long non‐coding RNA SNHG14 (lncRNA SNHG14) in gastric cancer (GC) progression and its underlying mechanisms. Compared with para‐carcinoma tissues, SNHG14 was upregulated in GC tissues, correlating with a poor prognosis in GC patients.
Bin Liu, Tingting Lu, Guangming Zhang, Xiaohua Dong, Miao Yu, Hui Cai   +5 more
wiley   +1 more source

Expression of Id proteins is regulated by the Bcl-3 proto-oncogene in prostate cancer

Oncogene, 2013
Kristofer Ahlqvist, Karunakar Saamarthy, A. S. S. Khaja, A. Bjartell, R. Massoumi   +4 more
semanticscholar   +1 more source

SMYD2 Promotes Renal Tubular Cell Apoptosis and Chronic Kidney Disease Following Cisplatin Nephrotoxicity

The FASEB Journal, Volume 39, Issue 10, 31 May 2025.
SMYD2 mediates the activation of the NF‐κB signaling pathway to promote cisplatin‐induced chronic kidney injury. Cisplatin stimulation induces the upregulation of SMYD2 expression in renal tubular epithelial cells. SMYD2 promotes the phosphorylation of the p65 subunit of NF‐κB through methylation, thereby facilitating the release of inflammatory ...
Siyang Zuo, Huixiong Yuan, Xia Li, Ming Chen, Rui Peng, Siyu Chen, Xue Zou, Yuan Yang, Hehua Long, Zeying Liu, Teng Wang, Bing Guo, Lirong Liu   +12 more
wiley   +1 more source