Results 121 to 130 of about 72,845 (194)

Diosgenin Attenuates Photoreceptor Degeneration in an N-Methyl-N-Nitrosourea-Induced Mouse Model of Retinal Degeneration. [PDF]

Invest Ophthalmol Vis Sci
Tong W, Cao J, Zhou X, Jia B, Li D, Fu J.   +5 more
europepmc   +1 more source

JI‐CJ002 and Dabrafenib Combination Enhances Antitumor Activity in Melanoma Associated With the Downregulation of B7‐H3

Cancer Science, Volume 117, Issue 6, Page 1651-1666, June 2026.
Schematic pathway diagram illustrating the effects of JI‐CJ002 and dabrafenib on melanoma progression. The combination of JI‐CJ002 and dabrafenib is associated with reduced B7‐H3 expression and modulation of signaling pathways implicated in melanoma progression, including JAK2/STAT3, PI3K/AKT/mTOR, and Rb/E2F1.
Sang‐Eun Lee, Young Ha Kim, Bo Shin Heo, Chunhoo Cheon, Seong‐Gyu Ko   +4 more
wiley   +1 more source

MGMT hypermethylation and BCL-2 overexpression associated with superficial bladder cancer and recurrence

, 2016
BACKGROUND: Urinary bladder carcinoma is one of the leading causes of death among men, and its high recurrence rates make it one of the most solid tumors to treat.
Mivehchi, M., Hosseini, S.A., Jahed, M., Asgari, M., Majidizadeh, T., Shahshanipour, M., Ebadi, N., Ghadakzadeh, S.   +7 more
core  

miR-17: from developmental regulatory hub to molecular engine driving tumourigenesis. [PDF]

Front Oncol
Zhang M, Ma YR, Chen XY, Sun TS, Wang XY, Wang BB, Wang FH.   +6 more
europepmc   +1 more source

The NF‐κB Signalling Pathway: Mechanisms, Consequences and Therapeutic Targets

Journal of Cellular and Molecular Medicine, Volume 30, Issue 11, June 2026.
ABSTRACT Nuclear Factor‐kappa B (NF‐κB) is a master transcriptional regulator orchestrating critical cellular processes, predominantly immunity and inflammation. However, its aberrant constitutive activation has emerged as a unifying pathogenetic hallmark across diverse malignancies, autoimmune disorders, and chronic inflammatory diseases.
Bherouz Pourdad, Arash Pourdad
wiley   +1 more source

JNK and ERK8 as downstream effectors of receptor tyrosine kinases

, 2006
MAP kinases are a super-family of serine-threonine protein kinases expressed in all eukaryotic cells. In mammals, there are many MAP kinases with different biological functions, grouped in distinctly regulated groups, ERK1/2 (extracellular signal related
Iavarone, Carlo
core  

Potential Efficacy of Luteolin in Cutaneous Squamous Cell Carcinoma: A Combined In Vitro and In Vivo Study. [PDF]

Biomolecules
Guo Y, Wang X, Gao Y, Xu Y, Fang Z, Liu S, Dong H, Luo J, Yan L.   +8 more
europepmc   +1 more source

Immune Evasion of Helicobacter pylori and Extra‐Gastric Cancer Risk

Journal of Gastroenterology and Hepatology, Volume 41, Issue 6, Page 1722-1742, June 2026.
ABSTRACT Helicobacter pylori (H. pylori) is a group 1 gastric carcinogen that plays a significant role in extra‐gastric digestive system cancers. H. pylori disrupts host cell homeostasis through expression of virulence factors leading to immune evasion as well as persistent gastric mucosal colonization. H. pylori infection has been shown to play a role
Evren Doruk Engin, Ayse Basak Engin, Atilla Engin   +2 more
wiley   +1 more source

Menopozun ve hormon replasman tedavisinin endometriumda estrojen ve progesteron reseptörleri ile Bcl-2 ve C-myc proto-onkogen proteinlerine etkilerinin immünohistokimyasal yöntemle incelenmesi

, 2019
Amaç: Menopozun ve hormon replasman tedavisinin (HRT), endometriumda estrojen ve progesteron reseptörleri ile bcl-2 ve c-myc proto-onkogen proteinleri üzerine etkilerinin immünohistokimyasal yöntemle araştırılması.
ÜÇKUYU, Ayla (Yazar), DÖKMECİ, Fulya (Tez Danışmanı)   +1 more
core  

Astragaloside IV Reduces Sorafenib-Induced Cardiotoxicity by Inhibiting Apoptosis Through the STAT3/HIF-1α/Bcl-2 Signaling Pathway. [PDF]

Int J Mol Sci
Wang L, Liu B, You Q, Cai H, Huang T, Lei Y, Wang H, Yao Y, Shao S, Guo H.   +9 more
europepmc   +1 more source