Results 31 to 40 of about 60,057 (198)

Nanoparticle‐Mediated Targeted Protein Degradation: An Emerging Therapeutics Technology

Angewandte Chemie, EarlyView.
Targeted protein degradation (TPD) has emerged as a powerful therapeutic approach, with numerous candidates molecules now advancing into clinical development. Recent innovations have incorporated nanoparticles to facilitate and enhance these degradation processes, yielding synergistic effects.
Andrew G. Baker, Adrian Pui Ting Ho, Laura S. Itzhaki, Ljiljana Fruk   +3 more
wiley   +2 more sources

bcl-2 proto-oncogene expression in normal and neoplastic human myeloid cells.

Blood, 1992
The present study provides immunobiochemical and molecular data on the differentiation-linked expression of the bcl-2 proto-oncogene in normal and neoplastic myeloid cells.
Domenico Delia, Antonella Aiello, D. Soligo, E. Fontanella, Cecilia Melani, Francesco Pezzella, M. A. Pierotti, G. Porta   +7 more
semanticscholar   +1 more source

Virtual Identification of Essential Proteins Within the Protein Interaction Network of Yeast [PDF]

, 2005
Topological analysis of large scale protein-protein interaction networks (PINs) is important for understanding the organisational and functional principles of individual proteins. The number of interactions that a protein has in a PIN has been observed to be correlated with its indispensability.
arxiv   +1 more source

Modulation of apoptosis by caprine herpesvirus 1 infection in a neuronal cell line [PDF]

, 2013
Caprine herpesvirus type 1 (CpHV-1), like other members of the alpha subfamily of herpesviruses, establishes latent infections in trigeminal ganglion neurons.
Antonio Giordano, Carmen Pacilio, CIARCIA, ROBERTO, Claudio De Martinis, IOVANE, GIUSEPPE, Ivanna Kenez, Maria Valeria Puzio, MONTAGNARO, SERENA, Morena De Angelis, PAGNINI, UGO, SASSO, SIMONA, Silvia Boffo   +11 more
core   +1 more source

Length, Protein-Protein Interactions, and Complexity [PDF]

, 2004
The evolutionary reason for the increase in gene length from archaea to prokaryotes to eukaryotes observed in large scale genome sequencing efforts has been unclear. We propose here that the increasing complexity of protein-protein interactions has driven the selection of longer proteins, as longer proteins are more able to distinguish among a larger ...
arxiv   +1 more source

The adaptor protein CRK is a pro-apoptotic transducer of endoplasmic reticulum stress. [PDF]

, 2011
Excessive demands on the protein-folding capacity of the endoplasmic reticulum (ER) cause irremediable ER stress and contribute to cell loss in a number of cell degenerative diseases, including type 2 diabetes and neurodegeneration.
Austgen, Kathryn, Curran, Tom, Johnson, Emily T, Oakes, Scott A, Park, Tae-Ju   +4 more
core  

Analyses of domains and domain fusions in human proto-oncogenes [PDF]

, 2009
Background: Understanding the constituent domains of oncogenes, their origins and their fusions may shed new light about the initiation and the development of cancers.
Bmc Bioinformatics, Huiqing Liu, Jinling Huang, Ping Wan, Qi Liu, Xiuzi Ye, Ying Xu   +6 more
core   +4 more sources

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Role of Sam68 in post-transcriptional gene regulation [PDF]

, 2013
The STAR family of proteins links signaling pathways to various aspects of post-transcriptional regulation and processing of RNAs. Sam68 belongs to this class of heteronuclear ribonucleoprotein particle K (hnRNP K) homology (KH) single domain-containing ...
Anderson, Andreotti, Arning, Auboeuf, Babic, Babic, Baehrecke, Barlat, Batsche, Bedford, Berson, Biamonti, Biamonti, Bianchi, Bielli, Burd, Busa, Busa, Chawla, Chen, Chen, Chen, Chen, Cheng, Cote, Cruz-Alvarez, Denegri, Derry, Di Fruscio, Di Fruscio, Dreyfuss, Ebersole, Finnen, Flora Sánchez-Jiménez, Fumagalli, Fusaki, Galarneau, Grossman, Guitard, Hartmann, Hawkins, Henao-Mejia, Hong, Huot, Huot, Iijima, Ishidate, Itoh, Jabado, Jauliac, Jones, Kim, Klein, Kunkel, Lang, Lawe, Li, Liao, Lin, Liu, Locatelli, Locatelli, Lukong, Lukong, Lukong, Lukong, Lynch, Maa, Martin-Romero, Matter, Messina, Meyer, Mezquita, Modem, Morishita, Najib, Najib, Naor, Paronetto, Paronetto, Paronetto, Paronetto, Paronetto, Paronetto, Pedrotti, Pedrotti, Piotrowska, Porkka, Rajan, Rajan, Ramakrishnan, Reddy, Resnick, Richard, Richard, Richard, Rosenberger, Ru, Sanchez-Jimenez, Sanchez-Jimenez, Sanchez-Margalet, Sanchez-Margalet, Sanchez-Margalet, Sanchez-Margalet, Sanchez-Margalet, Sellier, Sette, Simarro, Song, Soros, Stoss, Subramanyam, Suhasini, Tassone, Taylor, Taylor, Taylor, Tisserant, Tremblay, Trub, Ulke-Lemee, Valacca, Venables, Venigalla, Vernet, Víctor Sánchez-Margalet, Wang, Wang, Yang, Zhang, Zorn   +130 more
core   +2 more sources

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source