Results 41 to 50 of about 60,057 (198)

WT1 modulates apoptosis by transcriptionally upregulating the bcl‐2 proto‐oncogene

EMBO Journal, 1999
The Wilms‘ tumor suppressor gene, WT1, encodes a zinc finger transcription factor that has been demonstrated to negatively regulate several growth factor and cognate receptor genes.
M. Mayo, C. Y. Wang, S. Drouin, L. Madrid, A. Marshall, John Calvin Reed, B. Weissman, A. Baldwin   +7 more
semanticscholar   +1 more source

Design, Synthesis, and Anti-Leukemic Evaluation of a Series of Dianilinopyrimidines by Regulating the Ras/Raf/MEK/ERK and STAT3/c-Myc Pathways

Molecules
Although the long-term survival rate for leukemia has made significant progress over the years with the development of chemotherapeutics, patients still suffer from relapse, leading to an unsatisfactory outcome.
Chaoyan Wang, Bo Wang, Yu Mou, Xiang Liu, Qiqing Chen, Weidong Pu, Qing Rao, Chunlin Wang, Jingrui Song, Yubing Huang, Longjia Yan, Lei Huang, Yanmei Li   +12 more
doaj   +1 more source

BCL-W has a fundamental role in B cell survival and lymphomagenesis. [PDF]

, 2017
Compromised apoptotic signaling is a prerequisite for tumorigenesis. The design of effective therapies for cancer treatment depends on a comprehensive understanding of the mechanisms that govern cell survival.
Annette S. Kim, Barrett, Christine M. Eischen, Clare M. Adams, Gibson, Haldar, Jerald Z. Gong, John K. Choi, Lee, Placzek, Ramkrishna Mitra, Schmitz, Visco, Wang, Yang   +14 more
core   +2 more sources

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

Molecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach, Nilesh Chatterjee, Kellie Spahr, Gilberto Serrano de Almeida, Anabel Varela‐Carver, Taimur T. Shah, Mathias Winkler, Hashim U. Ahmed, Charlotte L. Bevan   +8 more
wiley   +1 more source

ProNet DB: A proteome-wise database for protein surface property representations and RNA-binding profiles [PDF]

arXiv, 2022
The rapid growth in the number of experimental and predicted protein structures and more complicated protein structures challenge users in computational biology for utilizing the structural information and protein surface property representation. Recently, AlphaFold2 released the comprehensive proteome of various species, and protein surface property ...
arxiv  

Broad targeting of resistance to apoptosis in cancer [PDF]

, 2015
Apoptosis or programmed cell death is natural way of removing aged cells from the body. Most of the anti-cancer therapies trigger apoptosis induction and related cell death networks to eliminate malignant cells. However, in cancer, de-regulated apoptotic
Abbas K. Samadi, Abulwerdi, Adams, Adhami, Adhami, Ajabnoor, Akgul, Alan Bilsland, Alexandros G. Georgakilas, Alt, Amedeo Amedei, Amr Amin, An, Anai, Anai, Angelo, Aoki, Arthur, Asfar S. Azmi, Awan, Ayshamgul, Azad, Azmi, Azmi, Azmi, Azmi, Azmi, Baguley, Baguley, Balaburski, Balakrishnan, Balakrishnan, Balakumaran, Balakumaran, Barkla, Basu, Beck, Beeram, Beeram, Beesoo, Bennett, Berchem, Berletch, Bernard, Billard, Billard, Boldogh, Bolesta, Bonkhoff, Bono, Boots, Booy, Borissenko, Bottazzi, bou-Nassar, Brandes, Bredberg, Brem, Brennan, Brohem, Bruel, Buggins, Buggins, Busacca, Bushunow, Cai, Caligaris-Cappio, Capparelli, Carew, Carew, Carew, Carmela Fimognari, Carmela Spagnuolo, Carter, Cascone, Chakravarti, Chan, Chandarlapaty, Chandra, Chandra S. Boosani, Chang, Chang, Chang, Chang, Chautan, Chen, Chen, Chen, Chen, Chen, Chen, Chen, Chen, Cheng, Cheng, Chio, Cho, Choan, Choi, Chondrogianni, Chook, Chopra, Chow, Chow, Chowdhury, Christophorou, Chung, Ciechanover, Clement Yedjou, Coley, Cortes Sempere, Cory, Czabotar, Dalla Via, Damle, Dangi-Garimella, Das, Das, Datta, Davenport, Davies, Degenhardt, Deng, Deng, Deveraux, Deveraux, Dewaele, Diaz-Chavez, Diekmann, Dighiero, Dimmeler, Dipita Bhakta, Dodou, Dorota Halicka, Dreyfuss, Du, Du, Dupere-Richer, Durig, Dutta, Duval, Edmond, Edmond, Edwards, Elena Niccolai, Elfadl, Elter, Etchin, Etchin, Etxebarria, Everett, Ewen, Farabegoli, Farnaes, Farnaes, Farrand, Ferguson, Filipova, Fimognari, Fimognari, Fischer, Forman, Fornerod, Fortugno, Fukuda, Fulda, Gandhi, Garcia, Garcia-Caballero, Garcia-Caballero, Geisler, George, Ghosh, Ghosh, Giampietri, Giampietri, Gian Luigi Russo, Glasspool, Gokbulut, Goncalves, Gozuacik, Gray-Schopfer, Gray-Schopfer, Grossman, Grossman, Gundala, Gunjan Guha, Gupta, Gupta, Gyurkocza, Haas-Kogan, Hallaert, Hallek, Hamamoto, Hamamoto, Hanahan, Hanahan, Hardtner, Haste, Haugk, Hayun, He, Helen M. Coley, Hinz, Hippert, Hiromasa Fujii, Hirose, Hoffmann, Hsu, Hsu, Hsue-Yin Hsu, Hu, Hu, Huang, Huang, Huang, Huang, Huang, Huanjie Yang, Hui, Hung, Huq, Hutten, Hwang, Inoue, Inoue, Irfana Muqbil, Ivanov, Iwado, Jaattela, Jackson, Jain, James D. Morre, Jang, Jatoi, Jentsch, Jesenberger, Jiang, Jiang, Jodoin, Johnson, Joo, Junttila, Kalid, Kaminski, Kaminskyy, Kang, Kang, Kanya Honoki, Karami, Karantanos, Kareva, Karmakar, Karni, Katia Aquilano, Kazi, Kazi, Kim, Kisselev, Kitagawa, Kitano, Kiviharju, Klarer, Knauer, Koga, Kondo, Korsmeyer, Kraehn, Krakstad, Kudo, Kumar, Kumar, Kumar, Kumar, Kuttan, Lacasse, Lai, Laurie, Le, Lee, Lee, Lenardo, Leroy Lowe, Lestini, Li, Li, Liang, Liang, Liang, Liang, Liang-Tzung Lin, Likui, Lin, Liu, Liu, Liu, Longo, Lopez, Lord, Lowman, Luo, Lv, Ma, Macfarlane, MacFarlane, Maiuri, Mandal, Manero, Mao, Marelli, Marfori, Maria Rosa Ciriolo, Markus David Siegelin, Marquez, Marubayashi, Masood, Masuda, Mathew, Mathew, Mathew, Matthew, Mayer, McBrayer, Mei, Merdzhanova, Messmer, Mi, Mi, Mihaljevic, Mo, Molinari, Moon, Moore, Morin, Mortenson, Mozzicafreddo, Mrinmay Chakrabarti, Mrowietz, Munoz-Gamez, Muqbil, Murdoch, Murdoch, Mutka, Nagano, Nagi B. Kumar, Nair, Nakagami, Nam, Nana-Sinkam, Newlands, Nguyen, Nicolau-Galmes, Niebler, Nor, Oakes, Oeffinger, Oikawa, Okuhashi, Op den Kamp, Oya, O’Connell, Pacak, Pal, Pan, Pan, Pang, Panischeva, Papandreou, Park, Parrondo, Patel, Pedros, Pepper, Pepper, Phelps, Piekielko-Witkowska, Pignochino, Pimkina, Pomerantz, Pradelli, Q. Ping Dou, Qi, Qin, Quinn, Raices, Ramalingam, Ramzi M. Mohammad, Rasheed, Reef, Rengarajan, Restall, Richardson, Richmond, Ringash, Roach, Robert, Robertson, Roman, Rosenbluh, Rosenfeldt, Russo, Russo, Russo, Russo, Russo, S. Salman Ashraf, Sagar, Sahin, Sakakibara, Salminen, Sato, Scherz-Shouval, Schneider, Schwartz, Seki, Sha, Shanafelt, Shanafelt, Shankar, Sharma, Shaulsky, Sheikh, Shen, Sherr, Shi, Shi, Shimamura, Shimamura, Shimamura, Shin, Siegel, Siegelin, Singh, Singh, Singh, Skandalis, Slocum, Smit, Smith, Snow, Socinski, Soderquist, Somaira Nowsheen, Sophie Chen, Souers, Spagnuolo, Spiegl-Kreinecker, Sprouse, Srinivasula, Stearns, Stommel, Sulma I. Mohammed, Sun, Swapan K. Ray, Syed, Tagscherer, Tahmatzopoulos, Tai, Tai, Tan, Tarnow, Tinhofer, Tomic, Torres, Trisciuoglio, Tsuruo, Tucker, Turkson, Turner, Valenti, Van, Van, van der Watt, Vellanki, Veronese, Videira, Vitagliano, Voelkel-Johnson, Vogelstein, Vogler, Vogler, Volkova, Voorhees, Voss, W. Nicol Keith, Walde, Walker, Walsby, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wang, Wanka, Warr, William G. Helferich, Wolter, Wood, Wu, Wyllie, Xi, Xu, Xu, Xujuan Yang, Yan, Yang, Yang, Yashiroda, Yecies, Yin, Yoneda, Yu, Yuan, Zgheib, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhang, Zhao, Zhao, Zhen, Zheng, Zheng, Zhong, Zhu, Zhu, Ziparo, Zuo   +535 more
core   +2 more sources

FEM1B enhances TRAIL‐induced apoptosis in T lymphocytes and monocytes

FEBS Open Bio, EarlyView.
FEM1B facilitates TRAIL‐induced apoptosis through distinct mechanisms in T lymphocytes and monocytes. In T lymphocytes, FEM1B engages with TRAF2, leading to a reduction in TRAF2 expression, which subsequently lessens TRAF2's inhibitory influence on caspase‐8.
Chenbo Yang, Wenhui Yu, Cui Dang, Jingjing Zhang, Jiahan Lu, Jing Xue   +5 more
wiley   +1 more source

bcl-2 proto-oncogene expression during human T cell development. Evidence for biphasic regulation.

Journal of Immunology, 1993
To ensure that the mature T cell repertoire is MHC-restricted yet not autoreactive, cortical thymocytes that express low levels of the TCR/CD3 complex along with CD4 and CD8 (double positive cells) are subjected to positive and negative selection ...
J. Gratiot-Deans, Liyun Ding, Laurence A. Turka, Gabriel Núñez   +3 more
semanticscholar   +1 more source

Histone deacetylases as new therapy targets for platinum-resistant epithelial ovarian cancer [PDF]

, 2016
Introduction: In developed countries, ovarian cancer is the fourth most common cancer in women. Due to the nonspecific symptomatology associated with the disease many patients with ovarian cancer are diagnosed late, which leads to significantly poorer ...
A Hayashi, A Mai, A Saito, A Vannini, A Villar-Garea, AA Lane, AJ Dembo, AJ Wilson, Albandri Alfraidi, AM Abukhdeir, Aun Muhammad, AW Kurian, B Sorbe, BA Goff, BD Strahl, BH Huang, BY Karlan, C Aghajanian, C Bosetti, C Campas-Moya, C Gomez-Raposo, CJ Dunton, CM Grozinger, CS Marcus, CT Lin, D Khabele, D Matei, D Mottet, D Strumberg, D Waltregny, DC Drummond, DD Bowtell, DE Marsden, DK Armstrong, DM Dinulescu, Dmitri Pchejetski, DO Bauerschlag, E Hu, E Smolle, E Verdin, G Piperno, G Tortolero-Luna, H Naora, HA Risch, Heba Alshaker, HL Cheng, I Cetin, IK Kolasa, J Boyd, J Morrison, J Permuth-Wey, J Plisiecka-Halasa, J Prat, J Sonnemann, J Zhang, JA Rauh-Hain, JE Bolden, JE Palmer, JF Stratton, JH Choi, JJ Hwang, JL Benedet, JL MacDonald, JL Walker, JM Piek, JP Secrist, JR Graff, JR Ribeiro, K Kudoh, K Ozaki, K Sawada, K Struhl, KA Lowe, KB Glaser, Keith Sacco, KF McGonigle, KR Cho, L Dai, Leonardo Monzon, M Booth, M Fung-Kee-Fung, M Kartalou, M Markman, M Ohmichi, M Schuijer, MF Fathalla, MJ Piccart, MJ Scanlan, MK Tuxen, ML Friedlander, MM Leitao, MS Finnin, MS Kim, N Einhorn, N Einhorn, N Takai, N Takai, N Takai, NC Hait, NG Gavalas, NS Bese, P Marks, P Zhu, PH Wang, R Furumai, RA Burger, RA Burger, RC Bast Jr, RF Ozols, RL Coleman, RP Warrell Jr, RP Wernyj, S Gregoire, S Rinaldi, S Senese, S Spiegel, SA Cannistra, SA Gayther, SA Gayther, SC Modesitt, SR Wedge, T Meyer, TJ Herzog, TJ Perren, TL Klug, V Auner, V Conteduca, W Fischle, W Weichert, X Qian, YV Shebzukhov   +130 more
core   +1 more source

Recent Applications of Mesoporous Silica Nanoparticles in Gene Therapy

Advanced Healthcare Materials, EarlyView.
The review summarizes the synthesis of mesoporous silica nanoparticles (MSNs) with modifiable surface properties, functionalization strategies, mechanism of therapeutic payload release, and current applications in gene therapy, focusing on their capabilities in the targeted delivery of therapeutic nucleic acids, CRISPR‐Cas systems, and other genetic ...
Tamanna Binte Huq, Punnya Anil Kumar Jeeja, Sudip Kumar Dam, Sabya Sachi Das, Juan L. Vivero‐Escoto   +4 more
wiley   +1 more source