Results 131 to 140 of about 34,292 (160)
Coptidis Rhizoma Water Extract Attenuates RANKL-Induced Osteoclast Differentiation via MAPK, Akt, and NF-κB Pathways and Prevents Ovariectomy (OVX)-Mediated Bone Loss. [PDF]
Int J Mol SciHan SY, Kim YK.
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Application of network pharmacology in traditional Chinese medicine for the treatment of cardiac diseases. [PDF]
Front PharmacolZhai X, Chen X, Xiao X, Wu L.
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Endocrinology, 1993 Growth hormone (GH) has been previously shown in Ob1771 adipose cells to transiently stimulate the expression of the c-fos gene by a protein kinase C (PKC)-dependent pathway. This regulation takes place at a transcriptional level. In the presence of cycloheximide (CHX), stimulation by PKC activators or by serum leads to a "superinduction" of the c-fos ...
Sylvie Barcellini-Couget
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Inhibition of proto-oncogene c-fos transcription by inhibitors of protein kinase C and ion transport
European Journal of Biochemistry, 1987 Both 4 beta-phorbol 12,13-didecanoate (PDD) and calcium ionophore A23187 induced c-fos mRNA accumulation with similar kinetics in human monocyte-like cells (U937). Their effects were additive. Cells pretreated with PDD were not induced to accumulate c-fos mRNA by PDD but remained responsive to the induction by A23187.
Motoko Shibanuma +2 more
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Journal of Cardiovascular Pharmacology, 1992 Endothelins (ETs) are potent regulatory peptides that cause numerous phenotypic changes in glomerular mesangial cells including differential regulation of gene expression and mitogenesis. Although the second messengers produced by activated ET receptors are well characterized, little is known about pathways of nuclear signaling.
Michael S. Simonson +3 more
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Alcohol and alcoholism (Oxford, Oxfordshire), 1994 Hepatic fibrosis is an important morphological feature of alcohol-induced liver injury. We previously reported that acetaldehyde stimulates collagen I and fibronectin gene transcription in rat fat-storing cell (FSC) culture. We here evaluated whether acetaldehyde increases Col I and FN gene transcription through the induction of c-fos and c-jun proto ...
ALESSANDRO CASIN +6 more
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, 1992 We have constructed two expression vectors in order to study the action of the HBV 17 Kd X protein on the c-fos and c-myc promoters. The results show that the promoters contain multiple elements that respond to X protein, suggesting involvement of multiple transcription factors. The exact mechanism of the interaction remains elusive, but our data allow
Maria Laura Avantaggiati +6 more
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Clinical Science, 1997 1. Studies of cells transfected with specific expression vectors allow functions of specific gene products to be investigated. We first established optimum conditions for transfection of neonatal cardiac myocytes in primary culture. Increased proto-oncogene expression has been implicated in the development of cardiac hypertrophy; we therefore wished to
Nicola K. Green +4 more
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Proceedings, annual meeting, Electron Microscopy Society of America, 1995 The proto-oncogenes c-fos and c-jun are members of a multigene family known as immediate early genes (IEG) that are transiently expressed in response to a wide variety of environmental stimuli. Homodimeric complexes of jun gene-family products and heterodimeric complexes of the jun and fos gene-family products form the transcription factor AP-1, which ...
Kelly BéruBé +3 more
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