Results 161 to 170 of about 106,346 (224)

Exosome‐Based Theranostic for Gastrointestinal Cancer: Advances in Biomarker Discovery and Therapeutic Engineering

Small Methods, EarlyView.
This review explores the dual roles of exosomes in gastrointestinal (GI) cancers as diagnostic biomarkers and therapeutic agents. It highlights advancements in exosomal miRNAs, lncRNAs, circRNAs, and proteins for cancer detection and prognosis. The study also examines engineering strategies for exosome‐based drug delivery systems, their potential to ...
Mohit J. Mehta, Dongjun Shin, Hyun Sung Park, Jun Su An, Seong Il Lim, Hyun Jin Kim, Seungpyo Hong, Jiyoon Bu   +7 more
wiley   +1 more source

Disruption of deoxyribonucleotide triphosphate biosynthesis leads to RAS proto-oncogene activation and perturbation of mitochondrial metabolism. [PDF]

J Biol Chem
Suspène R, Raymond KA, Guardado-Calvo P, Dairou J, Bonhomme F, Bonenfant C, Guyetant S, Lecomte T, Pagès JC, Vartanian JP.   +9 more
europepmc   +1 more source

Deciphering diverse cell‐death patterns to predict the prognosis and potential therapy target of hepatocellular carcinoma patients

VIEW, EarlyView.
Abstract Ninety percent of all primary liver malignancies are hepatocellular carcinomas (HCC), making liver cancer the third most common cause of cancer‐associated mortality. Different patterns of programmed cell death (PCD) are crucial for the survival of tumors, and they might serve as a prognostic marker for HCC.
Lin Ding, Qian Li, Wenjing Yang, Te Liu, Tongtong Tian, Yu Liu, Chunyan Zhang, Baishen Pan, Beili Wang, Fan Wu, Wei Guo   +10 more
wiley   +1 more source

Methyltransferase-like 14 promotes the tumorigenesis and proliferation of pancreatic cancer cells through myc proto-oncogene signaling pathway.

Cytojournal
Li J, Wang P, Liu F, Li Y, Wu Y, Wang F, Du J.   +6 more
europepmc   +1 more source

Transcription factor E2F1 promotes non-small cell lung cancer progression by activating the PI3K/AKT pathway through MCM4. [PDF]

J Cardiothorac Surg
Cai Y, Lu X, Li T, Liu J, Jiang L.
europepmc   +1 more source

Impact of Acute Endurance Exercise on Alternative Splicing in Skeletal Muscle

FASEB BioAdvances, EarlyView.
Current model on the effects of acute endurance exercise on the AS regulatory mechanism with key trans‐factors/RBPs (e.g., hnRNP‐A1, ‐A3, and TIA1). ABSTRACT Alternative splicing (AS) is a highly conserved posttranscriptional mechanism, generating mRNA variants to diversify the proteome.
Alexander Ahn, Jeongjin J. Kim, Aaron L. Slusher, Jeffrey Y. Ying, Eric Y. Zhang, Andrew T. Ludlow   +5 more
wiley   +1 more source

KIF3C inhibits the progression and proliferation of colorectal cancer. [PDF]

BMC Gastroenterol
Diallo MT, Chen B, Yao Q, Yan Z, Sun Q, Wang D.   +5 more
europepmc   +1 more source

Development of a Short Telomere Zebrafish Model for Accelerated Aging Research and Antiaging Drug Screening

Aging Cell, EarlyView.
Larvae derived from a cross between tert deficient and haploinsufficient fish show a premature aging phenotype, characterized by telomere attrition and early death. The ST2 larval model is a valuable tool for rapid screening of antiaging molecules. Given that organogenesis occurs within the first 48 h, this model also allows for the conduction of aging
David Hernández‐Silva, María D. López‐Abellán, Francisco J. Martínez‐Navarro, Jesús García‐Castillo, María L. Cayuela, Francisca Alcaraz‐Pérez   +5 more
wiley   +1 more source

System Analysis Identifies MYBL2 As a Novel Oncogene Target for Metastatic Prostate Cancer. [PDF]

J Cancer
Huang R, Li J, Zhu J, Deng W, Wang Z, Xiang S.   +5 more
europepmc   +1 more source

Reduction of DNA Topoisomerase Top2 Reprograms the Epigenetic Landscape and Extends Health and Life Span Across Species

Aging Cell, EarlyView.
This study demonstrates that reducing the enzyme topoisomerase Top2 or its mammalian homolog TOP2B promotes longevity across multiple species, including yeast, worms, and mice. At the cellular/molecular level, TOP2B reduction mitigates the major cellular aging hallmarks such as epigenetic alterations, cell senescence, lysosomal biogenesis, and ...
Man Zhu, Meng Ma, Lunan Luo, Feiyang Li, Jiashun Zheng, Yan Pan, Lu Yang, Ying Xiao, Ziyan Wang, Bo Xian, Yi Zheng, Hao Li, Jing Yang   +12 more
wiley   +1 more source