Results 11 to 20 of about 15,137 (114)

FAK acts as a suppressor of RTK-MAP kinase signalling in Drosophila melanogaster epithelia and human cancer cells [PDF]

, 2014
Receptor Tyrosine Kinases (RTKs) and Focal Adhesion Kinase (FAK) regulate multiple signalling pathways, including mitogen-activated protein (MAP) kinase pathway. FAK interacts with several RTKs but little is known about how FAK regulates their downstream
A Bergmann, A Boulay, A Ueda, AC Dar, B Corkery, B Gabriel, BA Edgar, BA Hay, BJ Dickson, C Grabbe, CJ Marshall, D Tenenbaum, DD Schlaepfer, DJ Sieg, E Macia, E Rainero, E Rainero, E Sandilands, E Sandilands, Emma Sandilands, FD Karim, FJ Diaz-Benjumea, G Adam, GL Fox, I Bongarzone, I Plaza-Menacho, I Rebay, Iain MacPherson, IH Gelman, J Cordero, J Fujimoto, J Verdu, J Zhao, Jesica Diaz Vera, Jim C. Norman, JR Infante, JT Parsons, JT Price, Juan Pablo Macagno, K Blochlinger, K Halfar, K Mesaki, K Sawamoto, L Henriksen, L Sadowski, LV Owens, M Agochiya, M Ayaki, M Freeman, M Grieco, M Miaczynska, M Roberts, M Santoro, M Therrien, M Vidal, M Vidal, Marcos Vidal, Margaret Frame, Marshall S. Horwitz, MC Frame, ME Grether, ME Irwin, MM Bradford, P Kurada, P-I Tsai, PM Siesser, R Gleichauf, R Ohta, RD Read, RH Palmer, Ruth Palmer, S Leboulleux, S Murakami, S Rizzolio, S Sigismund, SA Speicher, SM Jhiang, SY Chen, T Das, T Matsuo, T-H Chen, W Long, WG Cance, X Zhao, Y Zheng, Yachuan Yu, Z Lu   +86 more
core   +4 more sources

An approach for the identification of targets specific to bone metastasis using cancer genes interactome and gene ontology analysis [PDF]

, 2012
Metastasis is one of the most enigmatic aspects of cancer pathogenesis and is a major cause of cancer-associated mortality. Secondary bone cancer (SBC) is a complex disease caused by metastasis of tumor cells from their primary site and is characterized ...
A Clauset, A Ergün, A Subramanian, A-L Barabási, A-L Barabási, AH Wyllie, AJ Levine, B Vogelstein, B Weigelt, C Ortutay, C Secondini, CC Harris, CL Bailey, CL Chaffer, CL Smith, D Hanahan, D Hanahan, DH Jones, DJ Watts, DW Huang, E Cerami, E Eden, EK Sloan, F Emmert-Streib, G Bu, G Chen, Ganesh Bagler, GR Mundy, H Jeong, H Rangaswami, H Yu, H-S Wang, H-Y Chuang, J Lascorz, JA Blake, JE Talmadge, JL Dai, K Chu, K Eppert, K Matsumoto, KI Goh, KR Hess, L Freeman, M Cicek, M Smid, MA Yildirim, Matthias Dehmer, ME Higgins, MEJ Newman, MP Joy, MP Valta, MS Virk, NN Batada, P Jia, P Shannon, PF Jonsson, RS Taichman, S Dorogovtsev, S Maslov, S Mathivanan, S Peri, Shikha Vashisht, SR Rittling, SY Rhee, T Gene, T Koreckij, TA Guise, U Brandes, U Stelzl, W Chang, W Kozlow, WC Hahn, X Lu, X Zhang, XH-F Zhang, Y Kang, Y Mishina   +76 more
core   +7 more sources

Targeting of RET oncogene by naphthalene diimide-mediated gene promoter G-quadruplex stabilization exerts anti-tumor activity in oncogene-addicted human medullary thyroid cancer [PDF]

, 2016
Medullary thyroid cancer (MTC) relies on the aberrant activation of RET proto-oncogene. Though targeted approaches (i.e., tyrosine kinase inhibitors) are available, the absence of complete responses and the onset of resistance mechanisms indicate the ...
Beretta, Giovanni L, Borrello, Maria Grazia, Doria, Filippo, Folini, Marco, Freccero, Mauro, Lanzi, Cinzia, Lopergolo, Alessia, Perrone, Rosalba, Richter, Sara, Tortoreto, Monica, Zaffaroni, Nadia, Zuco, Valentina   +11 more
core   +1 more source

Glutathione Metabolism in Renal Cell Carcinoma Progression and Implications for Therapies [PDF]

, 2019
A significantly increased level of the reactive oxygen species (ROS) scavenger glutathione (GSH) has been identified as a hallmark of renal cell carcinoma (RCC). The proposed mechanism for increased GSH levels is to counteract damaging ROS to sustain the
Meierhofer, David, Xiao, Yi
core   +2 more sources

Activation of the Erk8 Mitogen-activated Protein (MAP) Kinase by RET/PTC3, a Constitutively Active Form of the RET Proto-oncogene [PDF]

, 2006
Mitogen-activated protein (MAP) kinases have a central role in several biological functions, including cell adhesion and spreading, chemotaxis, cell cycle progression, differentiation, and apoptosis.
Acunzo, Mario, Carlomagno, Francesca, Carlomagno, Maria Stella, Catania, Annunziata, Chiariello, Mario, Iavarone, Carlo, Melillo, Rosa Marina, Santoro, Massimo   +7 more
core   +2 more sources

Preferential expression of the transcription coactivator HTIF1alpha gene in acute myeloid leukemia and MDS-related AML [PDF]

, 2002
HTIF1α, a transcription coactivator which is able to mediate RARα activity and functionally interact with PML, is encoded by a gene on chromosome 7q32–34, which is a critical region in acute myeloid leukemias (AML). With the assumption that this gene may
AGUIARI, Gianluca, CASTOLDI, GL, CUNEO, Antonio, DE ANGELI, C, DEL SENNO, Laura, GANDINI, D, LANZA, F, MANZATI, E, PANDOLFI, PP   +8 more
core   +1 more source

RET mutation and increased angiogenesis in medullary thyroid carcinomas [PDF]

, 2016
Advanced medullary thyroid cancers (MTCs) are now being treated with drugs that inhibit receptor tyrosine kinases, many of which involved in angiogenesis.
Acquaviva, Giorgia, Boichard, Amélie, Casadei, Gian Piero, Checquolo, Saula, Colato, Chiara, de Biase, Dario, Durante, Cosimo, Ferdeghini, Marco, Filetti, Sebastiano, Pecce, Valeria, Rhoden, Kerry, Rosignolo, Francesca, Russo, Diego, Sponziello, Marialuisa, Tallini, Giovanni, Verrienti, Antonella, Visani, Michela   +16 more
core   +1 more source

mGluR2/3 agonist LY379268, by enhancing the production of GDNF, induces a time-related phosphorylation of RET receptor and intracellular signaling Erk1/2 in mouse striatum. [PDF]

, 2011
In the present study we aimed to verify if the enhancement of glial cell line-derived neurotrophic factor (GDNF) production in mouse striatum following treatment with LY379268 may also induce in the nigrostriatal system a time-related activation of RET ...
BELLUARDO, Natale, DI LIBERTO, Valentina, MUDO', Giuseppa   +2 more
core   +1 more source

Reduced RET expression in gut tissue of individuals carrying risk alleles of Hirschsprung's disease [PDF]

, 2010
Receptor tyrosine kinase (RET) single nucleotide polymorphisms (SNPs) are associated with the Hirschsprung's disease (HSCR). We investigated whether the amount of RET expressed in the ganglionic gut of human was dependent on the genotype of three ...
Chen, Y, GarciaBarceló, M, Leon, TYY, Lui, VCH, Miao, X, Ngan, ESW, So, MT, Tam, PKH, Wong, KKY, Yuan, ZW   +9 more
core   +1 more source

Oncogenic fusion protein BCR-FGFR1 requires the breakpoint cluster region-mediated oligomerization and chaperonin Hsp90 for activation. [PDF]

, 2020
Mutation and translocation of fibroblast growth factor receptors often lead to aberrant signaling and cancer. This work focuses on the t(8;22)(p11;q11) chromosomal translocation which creates the breakpoint cluster region (BCR) fibroblast growth factor ...
Bisom-Rapp, Ezra W, Donoghue, Daniel J, Meyer, April N, Nelson, Katelyn N, Peiris, Malalage N   +4 more
core   +2 more sources