Results 1 to 10 of about 48,376 (141)

Proto-oncogene tyrosine-protein kinase SRC (Src) inhibition in microglia relieves neuroinflammation in neuropathic pain mouse models. [PDF]

Bioengineered, 2021
Chronic neuroinflammation is an important factor in the development of neuropathic pain (NP). Excess microglia activation releases a mass of pro-inflammatory cytokines during neuroinflammation process, leading to a constant painful irritation of the sensory nerve.
Cai Y, Xu J, Cheng Q.
europepmc   +4 more sources

Src-homology domain 2 containing protein tyrosine phosphatase-1 (SHP-1) directly binds to proto-oncogene tyrosine-protein kinase Src (c-Src) and promotes the transcriptional activation of connexin 43 (Cx43). [PDF]

Bioengineered, 2022
The prevalence of atrial fibrillation (AF), which is one of the common arrhythmias in clinics, is increasing sharply and has affected millions of patients, which is expected to triple by 2050. The purpose of the study was to explore the regulatory relationship between Src-homology domain 2 containing protein tyrosine phosphatase-1 (SHP-1) and proto ...
Liu Y, Dai M, Yang P, Cao L, Lu L.
europepmc   +3 more sources

Angiotensin (ang) 1-7 inhibits ang II-induced atrial fibrosis through regulating the interaction of proto-oncogene tyrosine-protein kinase Src (c-Src) and Src homology region 2 domain-containing phosphatase-1 (SHP-1)). [PDF]

Bioengineered, 2021
To verify whether Ang-(1-7) produces an antagonistic effect on Ang II-mediated atrial remodeling. Ang II–induced HL-1 cell model and a rat model of Ang II–induced atrial remodeling were constructed and intervened with Ang II Ang-(1-7), AngII +Ang-(1-7), Ang II+ c-Src specific inhibitor (SU6656), and Ang II + Ang-(1-7) + SSG (SHP-1/2 specific inhibitor,
Lu L, Cao L, Liu Y, Chen Y, Fan J, Yin Y.   +5 more
europepmc   +4 more sources

In Silico Analysis To Explore Novel Inhibitors For Human Proto-oncogene Tyrosine Protein Kinase Src [PDF]

Nature Precedings, 2010
AbstractThe first oncogene and the first non receptor tyrosine kinase, Src, plays a key role in cell morphology, motility, proliferation and survival. Over expression of Src kinase activity disrupts the RAS pathway in signaling pathway, where it loses its ability to hydrolyse GTP and thus, leads to cancer.
Nagapriya Mahanandi, Dibyabhaba Pradhan, Amineni Umamaheswari   +2 more
core   +5 more sources

Genome-Wide Gene Expression Analysis Identifies the Proto-oncogene Tyrosine-Protein Kinase Src as a Crucial Virulence Determinant of Infectious Laryngotracheitis Virus in Chicken Cells. [PDF]

J Virol, 2016
ABSTRACT Given the side effects of vaccination against infectious laryngotracheitis (ILT), novel strategies for ILT control and therapy are urgently needed. The modulation of host-virus interactions is a promising strategy to combat the virus; however, the interactions between the host and avian ILT herpesvirus (ILTV) are unclear.
Li H, Wang F, Han Z, Gao Q, Li H, Shao Y, Sun N, Liu S.   +7 more
europepmc   +4 more sources

Ginkgo biloba extract suppresses hepatocellular carcinoma progression by inhibiting the recruitment of myeloid-derived suppressor cells through reduced CXCL1 secretion via SRC downregulation [PDF]

Frontiers in Immunology
BackgroundHepatocellular carcinoma (HCC) remains one of the leading causes of cancer-related mortality worldwide, characterized by poor prognosis and limited therapeutic efficacy.
Zhiliang Xu, Zhiliang Xu, Zhiliang Xu, Zhiliang Xu, Siqin Liang, Siqin Liang, Siqin Liang, Siqin Liang, Xiaoxiang You, Anan Jin, Anan Jin, Anan Jin, Anan Jin, Lei Mao, Lei Mao, Lei Mao, Lei Mao, Fangyan Zhong, Tinghao Yuan, Jun He, Bo Yi, Bo Yi, Bo Yi, Ming Li, Ming Li, Ming Li, Ming Li, Qiang Tu, Qiang Tu, Qiang Tu   +29 more
doaj   +2 more sources

The E3 ubiquitin ligase TRIM56 promotes aggregation and activation of Src protein through Lys63-linked polyubiquitination in hepatocellular carcinoma [PDF]

Cell Death and Disease
Elevated activity of proto-oncogene tyrosine kinase Src is associated with tumorigenesis and progression of hepatocellular carcinoma (HCC). It is well recognized that activation of Src is mainly driven by its intermolecular autophosphorylation.
Lihui Zhu, Xiuling Cui, Hongwei Xu, Min Yang, Lihui Han   +4 more
doaj   +2 more sources

NX-1607: lifting the Cbl-b brake to promote T cell activation through MAPK/ERK pathways [PDF]

Journal for ImmunoTherapy of Cancer
Casitas B lymphoma-b (Cbl-b) is an E3 ubiquitin ligase that serves as a critical brake on immune cell activations. It negatively fine-tunes immune responses through ubiquitination of signaling proteins. Cbl-b deficiency in mice leads to spontaneous tumor
Ryohichi Sugimura, Alex To
doaj   +2 more sources

Integrated analysis of ARHGAP6 potential function and prognostic value in acute myeloid leukemia. [PDF]

PLoS ONE
BackgroundLeukemia recurrence continues to be the primary cause of treatment failure, it is meaningful to find new biomarkers for its treatment. In this study, we aim to use cell line study to assess the expression and prognostic value of ARHGAP6 in ...
Debin Yang, Yuanzhe Li, Ping Ma, Fankai Xiao   +3 more
doaj   +2 more sources

Dasatinib targets c-Src kinase in cardiotoxicity

Toxicology Reports, 2023
Dasatinib is a multitargeted kinase inhibitor used for treatment of chronic myeloid leukemia and acute lymphoblastic leukemia. Unfortunately, treatment of cancer patients with some kinase inhibitors has been associated with cardiotoxicity.
Manar Elmadani, Sami Raatikainen, Orvokki Mattila, Tarja Alakoski, Jarkko Piuhola, Pirjo Åström, Olli Tenhunen, Johanna Magga, Risto Kerkelä   +8 more
doaj   +1 more source