Results 121 to 130 of about 31,892 (198)

USP8‐Dependent Family Tyrosine Kinase Promotes the Malignant Progression of Esophageal Squamous Cell Carcinoma by Upregulating Protein Tyrosine Kinase 2 Expression

Thoracic Cancer
Background Esophageal squamous cell carcinoma (ESCC) is a lethal malignancy, and the molecular underpinnings of its aggressive behavior are not fully understood.
Yuechang Wu, Dubiao Xian, Yunzhong Liu, Ding Huang, Qingfeng Liu, Shubo Yang   +5 more
doaj   +1 more source

Phosphoproteomic Analysis Identified Mutual Phosphorylation of FAK and Src as a Mechanism of Osimertinib Resistance in EGFR-Mutant Lung Cancer

JTO Clinical and Research Reports
Introduction: Osimertinib is a standard treatment for patients with EGFR-mutant NSCLC. Although some osimertinib resistance mechanisms have been identified, nearly 50% of the mechanisms remain to be elucidated.
Takehiro Tozuka, MD, Rintaro Noro, MD, PhD, Keisuke Yoshida, PhD, Satoshi Takahashi, MD, PhD, Mariko Hirao, MD, Kuniko Matsuda, MD, Yasuhiro Kato, MD, Shinji Nakamichi, MD, PhD, Susumu Takeuchi, MD, PhD, Masaru Matsumoto, MD, PhD, Akihiko Miyanaga, MD, PhD, Shinobu Kunugi, MD, PhD, Kazufumi Honda, DDS, PhD, Jun Adachi, PhD, Masahiro Seike, MD, PhD   +14 more
doaj  

Unveiling the cytotoxicity of Red Sea Moorena producens via LC-QTOF-MS/MS chemical profiling, network pharmacology, and molecular docking

Pharmaceutical Biology
Context Breast and liver cancers remain significant global health challenges, necessitating the discovery of novel anticancer agents. Marine cyanobacteria, such as Moorena producens belonging to the family: Oscillatoriaceae, are rich sources of bioactive
Esraa M. Abdelhady, Mohammed N. A. Khalil, Mohamed A. Rabeh, Saad A. Alshehri, Omar Sabry, Mona M. Hashem   +5 more
doaj   +1 more source

Nerve growth factor nonresponsive pheochromocytoma cells: altered internalization results in signaling dysfunction. [PDF]

, 1992
Variant rat pheochromocytoma (PC12) cells which fail to respond to nerve growth factor (NGF) (PC12nnr5) (Green, S. H., R. E. Rydel, J. L. Connoly, and L. A. Greene. 1986. J. Cell Biol. 102:830-843) bind NGF at both high and low affinity sites.
Bradshaw, RA, Eveleth, DD
core  

VEGF and EGFR signaling pathways are involved in the baicalein attenuation of OVA-induced airway inflammation and airway remodeling in mice

Respiratory Research
Background Although Traditional Chinese Medicine (TCM) has been used for treating asthma for centuries, the understanding of its mechanism of action is still limited.
Wang Peng, Qinxuan Xia, Yue Zhang, Danfeng Cao, Xiangrong Zheng   +4 more
doaj   +1 more source

The SRC/NF‐κB‐AKT/NOS3 axis as a key mediator of Kaempferol's protective effects against oxidative stress‐induced osteoclastogenesis

Immunity, Inflammation and Disease
Background Osteoclasts are integral to the advancement of osteoporosis (OP), and their generation under conditions of oxidative stress (OS) involves various pathways.
Jiaming Shen, Chunjie Hu, Yuelong Wang, Yiying Tan, Xiaochen Gao, Nanxi Zhang, Jingwei Lv, Jiaming Sun   +7 more
doaj   +1 more source

Dual Inhibition of SRC Family Kinases and Sorafenib Enhances Anti-Tumor Activity in Hepatocellular Carcinoma Cells. [PDF]

Int J Mol Sci
Cabral LK, Disoma C, Tarchi P, El-Khobar KE, Agustiningsih A, Dituri F, Tiribelli C, Sukowati C.   +7 more
europepmc   +1 more source

Network pharmacology study on the mechanism of Curcumae Rhizoma in the treatment of non-small cell lung cancer. [PDF]

Medicine (Baltimore)
Yang Z, Wu M, Zhou X, Luo J, Liu Y, Li L.   +5 more
europepmc   +1 more source

Molecular characterisation of ret tyrosine kinase signalling [PDF]

, 2005
Arighi, Elena
core  

Network Pharmacology and Molecular Docking-Based Approach to Explore Potential Bioactive Compounds from <i>Kaempferia parviflora</i> on Chemokine Signaling Pathways in the Treatment of Psoriasis Disease. [PDF]

Int J Mol Sci
Sakuludomkan C, Khowsathit J, Thippraphan P, Koonrungsesomboon N, Takuathung MN, Taychaworaditsakul W.   +5 more
europepmc   +1 more source