Results 161 to 170 of about 48,405 (170)

IL1A: a novel prognostic biomarker and potential therapeutic target for renal clear cell carcinoma. [PDF]

Oncol Res
Zeng JI, Meng X, Zhang Y, Li J, Ma T, Huang C.   +5 more
europepmc   +1 more source

Decoding Chronicity: Oxidative Stress and Inflammation as Systems Hubs. [PDF]

Biomedicines
Formanowicz D.
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Synergistic target network construction and dynamic simulation analysis based on a prospective systems pharmacology strategy. [PDF]

Medicine (Baltimore)
Li H, Zheng Z, Zhen G, Tang K, Fang H, Wang J, Liu X, Zhu D.   +7 more
europepmc   +1 more source

Exploring the mechanism of action of Kaixin San in treating dementia based on network pharmacology and molecular docking. [PDF]

Medicine (Baltimore)
Liu S, Zhang Z.
europepmc   +1 more source

Dasatinib Produces Lengthy Remissions of Extramedullary Leukemia: A Retrospective Observational Study. [PDF]

Eur J Haematol
Cunningham I, Fisher RA, Yang J, Guo Y, Bommhardt U.   +4 more
europepmc   +1 more source

Molecular insight on the role of the phosphoinositide PIP3 in regulating the protein kinases Akt, PDK1, and BTK. [PDF]

Biochem Soc Trans
Shaw AL, Burke JE.
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Progression on Mechanism and Therapeutic Implications of Neddylation in Lung Cancer. [PDF]

Oncol Res
Zou J, Lu Y, Li J, Zhou Z, Peng F, Qiu P, Tang H, Peng C.   +7 more
europepmc   +1 more source

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The proto-oncogene tyrosine protein kinase Src is essential for macrophage-myofibroblast transition during renal scarring

Kidney International, 2018
Src activation has been associated with fibrogenesis after kidney injury. Macrophage-myofibroblast transition is a newly identified process to generate collagen-producing myofibroblasts locally in the kidney undergoing fibrosis in a TGF-β/Smad3-dependent manner.
Patrick Ming-Kuen, Tang, Shuang, Zhou, Chun-Jie, Li, Jinyue, Liao, Jun, Xiao, Qing-Ming, Wang, Guang-Yu, Lian, Jinhong, Li, Xiao-Ru, Huang, Ka-Fai, To, Chi-Fai, Ng, Charing Ching-Ning, Chong, Ronald Ching-Wa, Ma, Tin-Lap, Lee, Hui-Yao, Lan   +14 more
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Cardiotoxin III suppresses the invasiveness of MDA-MB-231 cells by targeting proto-oncogene tyrosine-protein kinase Src and reversing mesenchymal-to-epithelial transition

Toxicological & Environmental Chemistry, 2016
ABSTRACTThe epithelial-to-mesenchymal transition is the first step required for breast cancer to initiate metastasis. The aberrant activation of proto-oncogene tyrosine-protein kinase Src regulates multiple functions during tumor progression. Cardiotoxin III, a basic polypeptide isolated from Naja naja atra venom, has been shown to exhibit anticancer ...
Pei-Chien Tsai, Yi-Ling Lin, Yaw-Syan Fu, Long-Sen Chang, Shinne-Ren Lin   +4 more
openaire   +1 more source

Targeting Self-Binding Peptides as a Novel Strategy To Regulate Protein Activity and Function: A Case Study on the Proto-oncogene Tyrosine Protein Kinase c-Src

Journal of Chemical Information and Modeling, 2017
Previously, we have reported a new biomolecular phenomenon spanning between protein folding and binding, termed as self-binding peptides (SBPs), where a short peptide segment in monomeric protein functions as a molecular switch by dynamically binding to/unbinding from its cognate domain in the monomer (Yang et al. J. Chem. Inf.2015, 55, 329-342). Here,
Zhengya Bai, Shasha Hou, Shilei Zhang, Zhongyan Li, Peng Zhou   +4 more
openaire   +2 more sources