Results 11 to 20 of about 48,405 (170)

SRC promotes lipogenesis: implications for obesity and breast cancer

Molecular & Cellular Oncology, 2021
Remodeling of lipid metabolism has been implicated in cancers; however, it remains obscure how the lipid metabolic pathways are altered by oncogenic signaling to affect tumor development. We have recently shown that proto-oncogene tyrosine-protein kinase
Shu-Yong Lin, Sheng-Cai Lin
doaj   +1 more source

Platelet Src family kinases: A tale of reversible phosphorylation

Research and Practice in Thrombosis and Haemostasis, 2021
Sarcoma (Src) family kinases (SFKs) have occupied a central place in platelet research for over 40 years. Discovered by virologists and oncologists as the proto proto‐oncogene, Src tyrosine kinase spurred a phenomenal burst of research on reversible ...
Yotis A. Senis, Zoltan Nagy, Jun Mori, Sophia Lane, Patrick Lane   +4 more
doaj   +1 more source

Protein tyrosine phosphatase PTPL1 suppresses lung cancer through Src/ERK/YAP1 signaling

Thoracic Cancer, 2022
Background To reveal the function of protein tyrosine phosphatase‐L1 (PTPL1) in lung adenocarcinoma. Methods Lung cancer cell lines were transfected with short hairpin RNA against PTPL1 (shPTPL1 group) or negative control (shmock group).
Jing Wang, Shuanghui Li, Xiujuan Zhang, Ning Zhu, Ruzetuoheti Yiminniyaze, Liang Dong, Chengwei Li, Wumaier Gulinuer, Jingwen Xia, Jing Li, Daibing Zhou, Xinning Liu, Youzhi Zhang, Yuanyuan Zhang, Shengqing Li   +14 more
doaj   +1 more source

Malignant progression of liver cancer progenitors requires lysine acetyltransferase 7–acetylated and cytoplasm‐translocated G protein GαS

Hepatology, EarlyView., 2022
KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou, Kaiwei Jia, Suyuan Wang, Zhenyang Li, Yunhui Li, Shan Lu, Yingyun Yang, Liyuan Zhang, Mu Wang, Yue Dong, Luxin Zhang, Wannian Zhang, Nan Li, Yizhi Yu, Xuetao Cao, Jin Hou   +15 more
wiley   +1 more source

Ca²⁺ Signaling and Src Functions in Tumor Cells

Biomolecules, 2023
Signaling by calcium ion (Ca2+) plays a prominent role in cell physiology, and these mechanisms are frequently altered in tumor cells. In this review, we consider the interplay of Ca2+ signaling and the functions of the proto-oncogene non-receptor ...
Antonio Villalobo
doaj   +1 more source

In-silico analysis reveals the core targets and mechanisms of CA028, a new derivative of calycosin, in the treatment of colorectal cancer

Intelligent Medicine, 2022
Background: Colorectal cancer (CRC) is a type of malignant gastroenteric tumors associated with a high mortality rate worldwide. Calycosin, a natural phytoestrogen, possesses potent anti-cancer properties.
Feiying Yin, Xing Zhang, Yu Li, Xiao Liang, Rong Li, Jian Chen   +5 more
doaj   +1 more source

Src Mediates Epigallocatechin-3-O-Gallate-Elicited Acid Sphingomyelinase Activation

Molecules, 2020
Epigallocatechin-3-O-gallate (EGCG) is one of the major bioactive compounds known to be present in green tea. We previously reported that EGCG shows selective toxicity through activation of the protein kinase B (Akt)/cyclic guanosine monophosphate (cGMP)/
Motofumi Kumazoe, Mai Kadomatsu, Jaehoon Bae, Yushi Otsuka, Yoshinori Fujimura, Hirofumi Tachibana   +5 more
doaj   +1 more source

Antitumor effect of the tyrosine kinase inhibitor nilotinib on gastrointestinal stromal tumor (GIST) and imatinib-resistant GIST cells. [PDF]

PLoS ONE, 2014
Despite the benefits of imatinib for treating gastrointestinal stromal tumors (GIST), the prognosis for high risk GIST and imatinib-resistant (IR) GIST remains poor. The mechanisms of imatinib resistance have not yet been fully clarified.
Hiroyuki Sako, Kazumasa Fukuda, Yoshiro Saikawa, Rieko Nakamura, Tsunehiro Takahashi, Norihito Wada, Hirohumi Kawakubo, Hiroya Takeuchi, Tai Ohmori, Yuko Kitagawa   +9 more
doaj   +1 more source

Single molecule fluorescence reveals dimerization of myristoylated Src N-terminal region on supported lipid bilayers [PDF]

, 2016
The proto-oncogene tyrosine-protein kinase Src is a key ele- ment of signaling cascades involved in the invasive and meta- stasis-forming capacity of cancer cells.
Castro, Bruno, Garbacik, Erik T., García-Parajó, Maria F., Le Roux, Anabel-Lise, Pons Vallès, Miquel   +4 more
core   +1 more source

Mechanism Prediction of Monotropein for the Treatment of Colorectal Cancer by Network Pharmacology Analysis

Digital Chinese Medicine, 2020
Objective: To discover the pharmacological mechanisms of monotropein in colorectal cancer by network pharmacology methods. Methods: The main-candidate-target network was constructed by the prediction of targets of monotropein, collection of therapeutic ...
Li Chong, Hou Shao-Zhen, Zhou Hua
doaj   +1 more source