The Src inhibitor dasatinib accelerates the differentiation of human bone marrow-derived mesenchymal stromal cells into osteoblasts [PDF]
BMC Cancer, 2010 Background The proto-oncogene Src is an important non-receptor protein tyrosine kinase involved in signaling pathways that control cell adhesion, growth, migration and differentiation.
Ghanem Ghanem +6 more
doaj +5 more sources
Protein tyrosine phosphatase PTPL1 suppresses lung cancer through Src/ERK/YAP1 signaling
Thoracic Cancer, 2022 Background To reveal the function of protein tyrosine phosphatase‐L1 (PTPL1) in lung adenocarcinoma. Methods Lung cancer cell lines were transfected with short hairpin RNA against PTPL1 (shPTPL1 group) or negative control (shmock group).
Jing Wang +14 more
doaj +1 more source
Ca2+ Signaling and Src Functions in Tumor Cells
Biomolecules, 2023 Signaling by calcium ion (Ca2+) plays a prominent role in cell physiology, and these mechanisms are frequently altered in tumor cells. In this review, we consider the interplay of Ca2+ signaling and the functions of the proto-oncogene non-receptor ...
Antonio Villalobo
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Hepatology, EarlyView., 2022 KAT7‐acetylated and cytoplasm‐translocated G‐protein GαS enhances IL‐6 effect and drives HCC progenitor cell progression. Abstract Background and Aims Hepatocarcinogenesis goes through HCC progenitor cells (HcPCs) to fully established HCC, and the mechanisms driving the development of HcPCs are still largely unknown.
Ye Zhou +15 more
wiley +1 more source
Antitumor effect of the tyrosine kinase inhibitor nilotinib on gastrointestinal stromal tumor (GIST) and imatinib-resistant GIST cells. [PDF]
PLoS ONE, 2014 Despite the benefits of imatinib for treating gastrointestinal stromal tumors (GIST), the prognosis for high risk GIST and imatinib-resistant (IR) GIST remains poor. The mechanisms of imatinib resistance have not yet been fully clarified.
Hiroyuki Sako +9 more
doaj +1 more source
Src Mediates Epigallocatechin-3-O-Gallate-Elicited Acid Sphingomyelinase Activation
Molecules, 2020 Epigallocatechin-3-O-gallate (EGCG) is one of the major bioactive compounds known to be present in green tea. We previously reported that EGCG shows selective toxicity through activation of the protein kinase B (Akt)/cyclic guanosine monophosphate (cGMP)/
Motofumi Kumazoe +5 more
doaj +1 more source
Single molecule fluorescence reveals dimerization of myristoylated Src N-terminal region on supported lipid bilayers [PDF]
, 2016 The proto-oncogene tyrosine-protein kinase Src is a key ele- ment of signaling cascades involved in the invasive and meta- stasis-forming capacity of cancer cells.
Castro, Bruno +4 more
core +1 more source
miR-203 suppresses the proliferation and migration and promotes the apoptosis of lung cancer cells by targeting SRC. [PDF]
PLoS ONE, 2014 SRC, also known as proto-oncogene c-Src, is a non-receptor tyrosine kinase that plays an important role in cancer progression by promoting survival, angiogenesis, proliferation, and invasion pathways.
Nan Wang +12 more
doaj +1 more source
Food & Nutrition Research, 2021 Background: Coronavirus disease 2019 (COVID-19) outbreak is progressing rapidly, and poses significant threats to public health. A number of clinical practice results showed that traditional Chinese medicine (TCM) plays a significant role for COVID-19 ...
Yuehua Wang +8 more
doaj +1 more source
Overexpression of Na+/Mg2+ exchanger SLC41A1 attenuates pro-survival signaling [PDF]
, 2017 The Na+/Mg2+ exchanger SLC41A1 (A1), a key component of intracellular Mg homeostasis (IMH), is the major cellular Mg2+ efflux system, and its overexpression decreases [Mg2+]intracellular.
Abdulhanan, Nasrin +9 more
core +1 more source