Receptor tyrosine kinase and p16/CDKN2 expression in a case of tripe palms associated with non-small-cell lung cancer [PDF]
, 1999 Background: Tripe palms is a descriptive term for a cutaneous paraneoplastic keratoderma. Tripe palms are frequently associated with gastric and pulmonary carcinoma. The pathogenetic mechanism remains unknown.
Bezold, G. +5 more
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Frontiers in Immunology, 2019 Hyper-inflammation during acute phase and sequential hypo-inflammation during immunosuppressive phase in macrophages/monocytes lead to multiorgan failure syndrome and immune collapse of sepsis, in which toll-like receptor (TLR)-triggered inflammatory ...
Wenqian Li +7 more
doaj +1 more source
Phase I dose-escalation and pharmacokinetic study of dasatinib in patients with advanced solid tumors [PDF]
, 2009 PURPOSE: To determine the maximum tolerated dose, dose-limiting toxicity (DLT), and recommended phase II dose of dasatinib in metastatic solid tumors refractory to standard therapies or for which no effective standard therapy exists.
Agarwal, Shruti +9 more
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Virulence, 2021 Thousands of human deaths occur annually due to Japanese encephalitis (JE), caused by Japanese encephalitis virus. During the virus infection of the central nervous system, reactive gliosis, uncontrolled inflammatory response, and neuronal cell death are
Usama Ashraf +5 more
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Computerized Protein Modeling and Molecular Docking Analysis of Human Proto Oncogene Tyrosine Protein Kinase YES for Discovery of Novel Lead Molecules [PDF]
, 2010 Human proto-oncogene tyrosine-protein kinase YES (YES) is a non receptor kinase belongs to Src family. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22.
Amineni Umamaheswari +2 more
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Dasatinib targets c-Src kinase in cardiotoxicity
Toxicology Reports, 2023 Dasatinib is a multitargeted kinase inhibitor used for treatment of chronic myeloid leukemia and acute lymphoblastic leukemia. Unfortunately, treatment of cancer patients with some kinase inhibitors has been associated with cardiotoxicity.
Manar Elmadani +8 more
doaj
Immunocytochemical localization of the neuron-specific form of the c-src gene product, pp60c-src(+), in rat brain [PDF]
, 1990 Neurons express high levels of a variant form of the c-src gene product, denoted pp60c-src(+), which contains a 6 amino acid insert in the amino-terminal half of the c-src protein.
Brugge, J. S. +4 more
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EGFR–c-Src-Mediated HDAC3 Phosphorylation Exacerbates Invasion of Breast Cancer Cells
Cells, 2019 Breast cancer is one of the leading causes of morbidity and mortality among women. Epidermal growth factor receptor (EGFR) and proto-oncogene tyrosine-protein kinase Src (c-Src) are critical components of the signaling pathways that are associated with ...
Sung-Min Kwak +9 more
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Frontiers in Pharmacology, 2022 Objective: People suffering from coronavirus disease 2019 (COVID-19) are prone to develop pulmonary fibrosis (PF), but there is currently no definitive treatment for COVID-19/PF co-occurrence. Kaempferol with promising antiviral and anti-fibrotic effects
Yong Jiang +14 more
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Expression and clinical significance of concomitant FAK/SRC and p-Paxillin in mobile tongue squamous cell carcinoma. [PDF]
, 2017 Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reservedBACKGROUND/AIM: The focal adhesion kinase (FAK)/SRC phosphorylation cascade and its downstream target paxillin have been implicated in ...
Alexandrou, Paraskevi +9 more
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