Results 41 to 50 of about 48,405 (170)

Functions of p120ctn in development and disease [PDF]

, 2012
p120 catenin (p120ctn), a component of the cadherin-catenin complex, was the first member to be identified in a most interesting subfamily of the Armadillo family. Several p120ctn isoforms are generated by alternative splicing.
Pieters, Tim, van Hengel, Jolanda, Van Roy, Frans   +2 more
core   +1 more source

Modeling Kaempferol as a Potential Pharmacological Agent for COVID-19/PF Co-Occurrence Based on Bioinformatics and System Pharmacological Tools

Frontiers in Pharmacology, 2022
Objective: People suffering from coronavirus disease 2019 (COVID-19) are prone to develop pulmonary fibrosis (PF), but there is currently no definitive treatment for COVID-19/PF co-occurrence. Kaempferol with promising antiviral and anti-fibrotic effects
Yong Jiang, Yi-Zi Xie, Yi-Zi Xie, Chen-Wen Peng, Chen-Wen Peng, Kai-Nan Yao, Xue-Ying Lin, Xue-Ying Lin, Shao-Feng Zhan, Hong-Fa Zhuang, Hui-Ting Huang, Xiao-Hong Liu, Xiu-Fang Huang, Xiu-Fang Huang, Hang Li   +14 more
doaj   +1 more source

Mutation of Vav1 adaptor region reveals a new oncogenic activation [PDF]

, 2014
International audienceVav family members function as remarkable scaffold proteins that exhibit both GDP/GTP exchange activity for Rho/Rac GTPases and numerous protein-protein interactions via three adaptor Src-homology domains.
Cormier, Françoise, Dondi, Elisabetta, Gardano, Laura, Guittat, Lionel, Katzav, Shulamit, Laurienté, Vanessa, Razanadrakoto, Lyra, Varin-Blank, Nadine   +7 more
core   +5 more sources

Hepatitis C virus induced miR200c down modulates FAP-1, a negative regulator of Src signaling and promotes hepatic fibrosis. [PDF]

PLoS ONE, 2013
Hepatitis C virus (HCV) induced liver disease is the leading indication for liver transplantation (LTx). Reinfection and accelerated development of fibrosis is a universal phenomenon following LTx. The molecular events that lead to fibrosis following HCV
Sabarinathan Ramachandran, Haseeb Ilias Basha, Nayan J Sarma, Yiing Lin, Jeffrey S Crippin, William C Chapman, Thalachallour Mohanakumar   +6 more
doaj   +1 more source

Transcriptional Profiling of PRKG2-Null Growth Plate Identifies Putative Down-Stream Targets of PRKG2 [PDF]

, 2015
Kinase activity of cGMP-dependent, type II, protein kinase (PRKG2) is required for the proliferative to hypertrophic transition of growth plate chondrocytes during endochondral ossification.
Cooper, Vickie, Kataria, Ranjit, Koltes, James, Kumar, Dinesh, Reecy, James, Reecy, James   +5 more
core   +3 more sources

Mutations of c-Cbl in myeloid malignancies [PDF]

, 2006
Next generation sequencing has shown the frequent occurrence of point mutations in the ubiquitin E3 ligase c-Cbl in myeloid malignancies. Mouse models revealed a causal contribution of c-Cbl for the onset of such neoplasms.
Bloomfield, Weissman, Weissman, Weissman, Weissman, Weissman, Zon, Sigvardsson, Cancer Genome, Baltimore, Birnbaum, Huibregtse, Weissman, Weissman, Dikic, Lipkowitz, Huang, Inagaki, Lipkowitz, Liu, Yarden, Chen, Swaminathan, Samelson, Schmitz, Oliver, Spiekermann, Maciejewski, Chase, Lipkowitz, Whitman, Maciejewski, Bock, Masuda, Birnbaum, Kawamata, Band, Reiter, Bowtell, Band, Langdon, Chaffanet, Rodriguez, Aplan, Voet, Shih, Haferlach, Hirai, Corey, Corey, Hattori, Lowell, Shimizu, Loh, Barber, Roussel, Flavell, Sieweke, Stanley, Berton, Stanley, Cortes, Penninger, Anderson   +63 more
core   +4 more sources

Inhibition of SHP2-mediated dephosphorylation of Ras suppresses oncogenesis [PDF]

, 2015
Ras is phosphorylated on a conserved tyrosine at position 32 within the switch I region via Src kinase. This phosphorylation inhibits the binding of effector Raf while promoting the engagement of GTPase-activating protein (GAP) and GTP hydrolysis.
Alamsahebpour, Amir, Bunda, Severa, Burrell, Kelly, Heir, Pardeep, Kano, Yoshihito, Ohh, Michael, Raught, Brian, Zadeh, Gelareh, Zeng, Lifan, Zhang, Zhong-Yin   +9 more
core   +1 more source

Anti-Cancer Potential of Oxialis obtriangulata in Pancreatic Cancer Cell through Regulation of the ERK/Src/STAT3-Mediated Pathway

Molecules, 2020
As a plant medicine, Oxalidaceae has been used to treat various diseases in Korea. However, there is little data on the anti-cancer efficacy of Oxalidaceae, particularly O. obtriangulata.
Eun-Jin An, Yumi Kim, Seung-Hyeon Lee, Hyun Min Ko, Won-Seok Chung, Hyeung-Jin Jang   +5 more
doaj   +1 more source

Drug target optimization in chronic myeloid leukemia using innovative computational platform. [PDF]

, 2015
Chronic Myeloid Leukemia (CML) represents a paradigm for the wider cancer field. Despite the fact that tyrosine kinase inhibitors have established targeted molecular therapy in CML, patients often face the risk of developing drug resistance, caused by ...
Benque, David, Chuang, Ryan, Cook, Byron, Fisher, Jasmin, Gottgens, Berthold, Hall, Benjamin A, Ishtiaq, Samin, Koschmieder, Steffen, Piterman, Nir, Taylor, Alex, Vardi, Moshe   +10 more
core   +2 more sources

An approach for the identification of targets specific to bone metastasis using cancer genes interactome and gene ontology analysis [PDF]

, 2012
Metastasis is one of the most enigmatic aspects of cancer pathogenesis and is a major cause of cancer-associated mortality. Secondary bone cancer (SBC) is a complex disease caused by metastasis of tumor cells from their primary site and is characterized ...
A Clauset, A Ergün, A Subramanian, A-L Barabási, A-L Barabási, AH Wyllie, AJ Levine, B Vogelstein, B Weigelt, C Ortutay, C Secondini, CC Harris, CL Bailey, CL Chaffer, CL Smith, D Hanahan, D Hanahan, DH Jones, DJ Watts, DW Huang, E Cerami, E Eden, EK Sloan, F Emmert-Streib, G Bu, G Chen, Ganesh Bagler, GR Mundy, H Jeong, H Rangaswami, H Yu, H-S Wang, H-Y Chuang, J Lascorz, JA Blake, JE Talmadge, JL Dai, K Chu, K Eppert, K Matsumoto, KI Goh, KR Hess, L Freeman, M Cicek, M Smid, MA Yildirim, Matthias Dehmer, ME Higgins, MEJ Newman, MP Joy, MP Valta, MS Virk, NN Batada, P Jia, P Shannon, PF Jonsson, RS Taichman, S Dorogovtsev, S Maslov, S Mathivanan, S Peri, Shikha Vashisht, SR Rittling, SY Rhee, T Gene, T Koreckij, TA Guise, U Brandes, U Stelzl, W Chang, W Kozlow, WC Hahn, X Lu, X Zhang, XH-F Zhang, Y Kang, Y Mishina   +76 more
core   +7 more sources