Results 51 to 60 of about 48,405 (170)

Molecular Mechanism of Naringenin Against High-Glucose-Induced Vascular Smooth Muscle Cells Proliferation and Migration Based on Network Pharmacology and Transcriptomic Analyses

Frontiers in Pharmacology, 2022
Although the protective effects of naringenin (Nar) on vascular smooth muscle cells (VSMCs) have been confirmed, whether it has anti-proliferation and anti-migration effects in high-glucose-induced VSMCs has remained unclear.
Wenjun He, Wenjun He, Wenjun He, Yanming Wang, Yanming Wang, Yanming Wang, Rui Yang, Rui Yang, Rui Yang, Huihui Ma, Huihui Ma, Huihui Ma, Xuqing Qin, Xuqing Qin, Xuqing Qin, Meijuan Yan, Meijuan Yan, Meijuan Yan, Yi Rong, Yi Rong, Yi Rong, Yufang Xie, Yufang Xie, Yufang Xie, Li Li, Junqiang Si, Junqiang Si, Junqiang Si, Xinzhi Li, Xinzhi Li, Xinzhi Li, Ketao Ma, Ketao Ma, Ketao Ma   +33 more
doaj   +1 more source

Severe B Cell Deficiency in Mice Lacking the Tec Kinase Family Members Tec and Btk [PDF]

, 2000
The cytoplasmic protein tyrosine kinase Tec has been proposed to have important functions in hematopoiesis and lymphocyte signal transduction. Here we show that Tec-deficient mice developed normally and had no major phenotypic alterations of the immune ...
Baltimore, David, Ellmeier, Wilfried, Hatam, Farah, Jung, Steffen, Littman, Dan R., Mano, Hiroyuki, Sunshine, Mary Jean, Xu, Yang   +7 more
core   +3 more sources

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Signal Transduction Mechanisms of Focal Adhesions: Src and FAK-Mediated Cell Response

Frontiers in Bioscience-Landmark
Cell-to-substrate adhesion sites, also known as focal adhesion sites (FAs), are complexes of different proteins on the cell surface. FAs play important roles in communication between cells and the extracellular matrix (ECM), leading to signal ...
Kazuo Katoh
doaj   +1 more source

Data-mining technique identifies potential target proteins playing a dual role in inflammation and oxidative stress pathways in relation to atherosclerosis plaque development

Informatics in Medicine Unlocked, 2020
Cardiovascular diseases (CVDs) are the leading cause of death worldwide. An underlying source of most CVDs is atherosclerosis. The scarcity of effective drugs, and the side effects of existing marketed drugs, necessitates the discovery of new promising ...
Arun Bahadur Gurung, Pritam Borah, Atanu Bhattacharjee   +2 more
doaj   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

SRC and MEK Co-inhibition Synergistically Enhances the Anti-tumor Effect in Both Non-small-cell Lung Cancer (NSCLC) and Erlotinib-Resistant NSCLC

Frontiers in Oncology, 2019
Non-small-cell lung cancer (NSCLC) is the predominant form of lung cancer, and it is regulated by a complex signal transduction network. Single-agent targeted therapy often results in acquired resistance, which leads to treatment failure.
Man Yuan, Lin-feng Xu, Juan Zhang, Si-yuan Kong, Man Wu, Yuan-zhi Lao, Hua Zhou, Li Zhang, Hongxi Xu, Hongxi Xu   +9 more
doaj   +1 more source

Analyses of domains and domain fusions in human proto-oncogenes [PDF]

, 2009
Background: Understanding the constituent domains of oncogenes, their origins and their fusions may shed new light about the initiation and the development of cancers.
Bmc Bioinformatics, Huiqing Liu, Jinling Huang, Ping Wan, Qi Liu, Xiuzi Ye, Ying Xu   +6 more
core   +4 more sources

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Proteomics analysis in myocardium of spontaneously hypertensive rats

Scientific Reports, 2023
Hypertension-related left ventricular hypertrophy is recognized as a good predictor of adverse cardiovascular events. However, the underlying mechanism of left ventricular hypertrophy is still not fully understood.
Tingjun Wang, Xiaoqi Cai, Jinze Li, Liangdi Xie   +3 more
doaj   +1 more source