Results 51 to 60 of about 31,892 (198)

Liver‐specific lncRNAs associated with liver cancers

FEBS Open Bio, EarlyView.
Long non‐coding RNAs (lncRNAs) are regulatory molecules with various functions. They are more tissue‐specific than proteins and can be used as potential biomarkers, particularly in cancer diagnostics and prognosis. In this review, we have systematically compiled all lncRNAs with exclusive expression in the human liver, verified their liver specificity ...
Olga Y. Burenina, Roman K. Makarchenko, Maria P. Rubtsova, Olga A. Dontsova   +3 more
wiley   +1 more source

Characterization of anti-leukemia components from Indigo naturalis using comprehensive two-dimensional K562/cell membrane chromatography and in silico target identification. [PDF]

, 2016
Traditional Chinese Medicine (TCM) has been developed for thousands of years and has formed an integrated theoretical system based on a large amount of clinical practice.
Cao, Yan, Chai, Yifeng, Chen, Xiaofei, Dan, Jia, Diao, Yong, Gao, Shouhong, Guo, Zhiying, Wu, Xunxun, Zerbe, Philipp, Zhang, Lei   +9 more
core   +1 more source

Mutation of Vav1 adaptor region reveals a new oncogenic activation [PDF]

, 2014
International audienceVav family members function as remarkable scaffold proteins that exhibit both GDP/GTP exchange activity for Rho/Rac GTPases and numerous protein-protein interactions via three adaptor Src-homology domains.
Cormier, Françoise, Dondi, Elisabetta, Gardano, Laura, Guittat, Lionel, Katzav, Shulamit, Laurienté, Vanessa, Razanadrakoto, Lyra, Varin-Blank, Nadine   +7 more
core   +8 more sources

Probing the mechanism of action (MOA) of Solanum nigrum Linn against breast cancer using network pharmacology and molecular docking

SN Applied Sciences, 2023
Solanum nigrum Linn is a medicinal herb widely used in traditional Chinese medicine to treat ailments such as fever, inflammation and cancer. Although quite a few compounds have been isolated and characterized, its anticancer mechanism remains elusive ...
Yingying Song, Meena Kishore Sakharkar, Jian Yang   +2 more
doaj   +1 more source

Estrogen Decreases Cytoskeletal Organization by Forming an ERα/SHP2/c-Src Complex in Osteoclasts to Protect against Ovariectomy-Induced Bone Loss in Mice

Antioxidants, 2021
Loss of ovarian function is closely related to estrogen (E2) deficiency, which is responsible for increased osteoclast (OC) differentiation and activity.
Hyun-Jung Park, Malihatosadat Gholam-Zadeh, Sun-Young Yoon, Jae-Hee Suh, Hye-Seon Choi   +4 more
doaj   +1 more source

DNA‑Directed Assembly of Photonic Nanomaterials for Diagnostic and Therapeutic Applications

Advanced Materials, EarlyView.
DNA‐directed assembly offers a powerful strategy for constructing structured photonic nanomaterials with precise spatial control. This review provides a comprehensive overview of recent advancements in DNA‐assembled photonic nanomaterials for diagnostics and therapeutics, highlighting key design principles, functionalization strategies, and optical ...
Longjiang Ding, Bing Liu, Andreas Peil, Sisi Fan, Jie Chao, Na Liu   +5 more
wiley   +1 more source

Signal Transduction Mechanisms of Focal Adhesions: Src and FAK-Mediated Cell Response

Frontiers in Bioscience-Landmark
Cell-to-substrate adhesion sites, also known as focal adhesion sites (FAs), are complexes of different proteins on the cell surface. FAs play important roles in communication between cells and the extracellular matrix (ECM), leading to signal ...
Kazuo Katoh
doaj   +1 more source

PTPN2 Inhibition Disrupts Mitochondrial Renewal and Blocks TFRC‐Mediated Mitophagy to Exert Anti‐Tumor Activities in ALK‐Positive Anaplastic Large Cell Lymphoma

Advanced Science, EarlyView.
CRISPR/Cas9 screening reveals PTPN2 as essential for ALK+ ALCL survival. PTPN2 regulates TFRC to promote PINK1‐PRKN mitophagy. Oral PTPN2 inhibitor ABBV‐CLS‐484 disrupts mitochondrial renewal and blocks TFRC‐mediated mitophagy to exert anti‐tumor activities, supporting clinical development for ALK+ ALCL.
Wei‐Ting Wang, Zi‐Wen Duan, Tong‐Yao Xing, Wei Hua, Kai‐Xing Du, Chun‐Yu Shang, Yi‐Fan Wu, Li Wang, Jian‐Yong Li, Rui Gao, Jin‐Hua Liang, Wei Xu   +11 more
wiley   +1 more source

Role of Sam68 in post-transcriptional gene regulation [PDF]

, 2013
The STAR family of proteins links signaling pathways to various aspects of post-transcriptional regulation and processing of RNAs. Sam68 belongs to this class of heteronuclear ribonucleoprotein particle K (hnRNP K) homology (KH) single domain-containing ...
Anderson, Andreotti, Arning, Auboeuf, Babic, Babic, Baehrecke, Barlat, Batsche, Bedford, Berson, Biamonti, Biamonti, Bianchi, Bielli, Burd, Busa, Busa, Chawla, Chen, Chen, Chen, Chen, Cheng, Cote, Cruz-Alvarez, Denegri, Derry, Di Fruscio, Di Fruscio, Dreyfuss, Ebersole, Finnen, Flora Sánchez-Jiménez, Fumagalli, Fusaki, Galarneau, Grossman, Guitard, Hartmann, Hawkins, Henao-Mejia, Hong, Huot, Huot, Iijima, Ishidate, Itoh, Jabado, Jauliac, Jones, Kim, Klein, Kunkel, Lang, Lawe, Li, Liao, Lin, Liu, Locatelli, Locatelli, Lukong, Lukong, Lukong, Lukong, Lynch, Maa, Martin-Romero, Matter, Messina, Meyer, Mezquita, Modem, Morishita, Najib, Najib, Naor, Paronetto, Paronetto, Paronetto, Paronetto, Paronetto, Paronetto, Pedrotti, Pedrotti, Piotrowska, Porkka, Rajan, Rajan, Ramakrishnan, Reddy, Resnick, Richard, Richard, Richard, Rosenberger, Ru, Sanchez-Jimenez, Sanchez-Jimenez, Sanchez-Margalet, Sanchez-Margalet, Sanchez-Margalet, Sanchez-Margalet, Sanchez-Margalet, Sellier, Sette, Simarro, Song, Soros, Stoss, Subramanyam, Suhasini, Tassone, Taylor, Taylor, Taylor, Tisserant, Tremblay, Trub, Ulke-Lemee, Valacca, Venables, Venigalla, Vernet, Víctor Sánchez-Margalet, Wang, Wang, Yang, Zhang, Zorn   +130 more
core   +2 more sources

The Immune Microenvironment: New Therapeutic Implications in Organ Fibrosis

Advanced Science, EarlyView.
This review summarizes recent advances in understanding the immune microenvironment's role in fibrosis, focusing on phenotypic/functional alterations of immune cells and their dynamic interactions with other cellular constituents within tissues. The authors further explore therapeutic opportunities and challenges in targeting immune microenvironment ...
Xiangqi Chen, Chuan Wu, Fei Tang, Jingyue Zhou, Li Mo, Yanping Li, Jinhan He   +6 more
wiley   +1 more source