Results 71 to 80 of about 31,892 (198)

Ubiquitination in cancer: mechanisms and therapeutic opportunities

Cancer Communications, EarlyView.
Abstract Ubiquitination, a key post‐translational modification, plays an essential role in tumor biology by regulating fundamental cellular processes, such as metabolism and cell death. Additionally, it interacts with other post‐translational modifications, which are closely linked to tumorigenesis, tumor progression, the tumor microenvironment, and ...
Susi Zhu, Xu Zhang, Waner Liu, Zhe Zhou, Siyu Xiong, Jie Li, Xiang Chen, Cong Peng   +7 more
wiley   +1 more source

Severe B Cell Deficiency in Mice Lacking the Tec Kinase Family Members Tec and Btk [PDF]

, 2000
The cytoplasmic protein tyrosine kinase Tec has been proposed to have important functions in hematopoiesis and lymphocyte signal transduction. Here we show that Tec-deficient mice developed normally and had no major phenotypic alterations of the immune ...
Baltimore, David, Ellmeier, Wilfried, Hatam, Farah, Jung, Steffen, Littman, Dan R., Mano, Hiroyuki, Sunshine, Mary Jean, Xu, Yang   +7 more
core   +3 more sources

Harnessing Viral Proteases for Cellular and Molecular Engineering

Chemistry–Methods, EarlyView.
Engineered viral proteases (VIPs) provide programmable control of protein function with high specificity and low toxicity. Integrated with chemogenetic and optogenetic modules, these VIP systems enable logic gate manipulation for targeted regulation of cell signaling, gene expression, protein secretion, and degradation, thereby offering versatile ...
Mingguang Cui, Tien‐Hung Lan, Yubin Zhou   +2 more
wiley   +1 more source

Charting the NF-kB pathway interactome map [PDF]

, 2010
One of the phenomena observed in human aging is the progressive increase of a systemic inflammatory state, a condition referred to as “inflammaging”, negatively correlated with longevity. The five components of the Nuclear Factor kB (NF-kB)
Alberto Termanini, Claudio Franceschi, Elena Bellavista, Paolo Tieri, Stefano Salvioli   +4 more
core   +2 more sources

Hepatitis B viral core protein disrupts human host gene expression by binding to promoter regions

BMC Genomics, 2012
Background The core protein (HBc) of hepatitis B virus (HBV) has been implicated in the malignant transformation of chronically-infected hepatocytes and displays pleiotropic functions, including RNA- and DNA-binding activities.
Guo Yanhai, Kang Wei, Lei Xiaoying, Li Yongnian, Xiang An, Liu Yonglan, Zhao Jinrong, Zhang Ju, Yan Zhen   +8 more
doaj   +1 more source

Exploring the Potential of Tsuruazuki Bean as a Functional Food to Curb Obesity Using Human Amniotic Epithelial Cells and 3T3‐L1 Preadipocytes

Food Frontiers, EarlyView.
Obesity is a global health problem that requires research and regulatory attention. This research aims to investigate transcriptome‐wide changes induced by Vigna umbellata (Tsuruazuki) using a stem cell‐based tool and preadipocytes to explore its untapped potential as a functional food for anti‐obesity applications.
Elda Nurafnie Ibnu Rasid, Farhana Ferdousi, Kazunori Sasaki, Kyoko Toda, Shinya Takahashi, Mari Maeda‐Yamamoto, Hiroko Isoda   +6 more
wiley   +1 more source

Constitutive association of BRCA1 and c-Abl and its ATM-dependent disruption after irradiation [PDF]

, 2002
BRCA1 plays an important role in mechanisms of response to double-strand breaks, participating in genome surveillance, DNA repair, and cell cycle checkpoint arrests.
Favaudon, V., Foray, N., Jeggo, P., Marot, D., Perricaudet, M., Picard, D., Randrianarison, V., Venezia, N. D.   +7 more
core   +2 more sources

Patient‐derived xenograft models in pan‐cancer: From bench to clinic

Interdisciplinary Medicine, EarlyView.
Abstract Patient‐derived xenograft (PDX) models provide a robust preclinical platform that preserves the genetic and phenotypic heterogeneity of patient tumors while mirroring their tumor genetic characteristics, which retain malignant cells and the tumor pathological structure, making them valuable for studying tumor progression and developing ...
Jiatong Li, Ao Gu, Nannan Tang, Gokhan Zengin, Meng‐Yao Li, Yingbin Liu   +5 more
wiley   +1 more source

Targeted polypharmacology: discovery of dual inhibitors of tyrosine and phosphoinositide kinases. [PDF]

, 2008
The clinical success of multitargeted kinase inhibitors has stimulated efforts to identify promiscuous drugs with optimal selectivity profiles. It remains unclear to what extent such drugs can be rationally designed, particularly for combinations of ...
Aizenstein, Brian, Apsel, Beth, Blair, Jimmy A, Feldman, Morri E, Gonzalez, Beatriz, Hoffman, Randy, Knight, Zachary A, Nazif, Tamim M, Shokat, Kevan M, Williams, Roger L   +9 more
core  

Recent Progress in Treating Airway Mucus Hypersecretion by Targeting the Epidermal Growth Factor Receptor Signaling Pathway

Pediatric Discovery, EarlyView.
ABSTRACT Asthma, chronic pulmonary obstructive disease (COPD), cystic fibrosis, and acute respiratory infections are severe respiratory conditions that significantly contribute to global morbidity and mortality. Airway mucus hypersecretion is an important common pathophysiological and clinical manifestation of these diseases and is closely associated ...
Yuanyuan Zhang, Fuping Yang, Chunyu Yan, Yu Deng, Enmei Liu   +4 more
wiley   +1 more source