Results 221 to 230 of about 226,605 (267)
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Proto‐Oncogenes in Development and Cancer
American Journal of Reproductive Immunology, 1991ABSTRACT: Although analogies are often made comparing development to cancer, there is of course a major difference. Normal development requires complex patterns of rigidly controlled cell proliferation and differentiation. In contrast, cancer represents the pathological condition that results when normal cell growth patterns are uncoupled from their ...
Geoffrey M. Cooper, Donald S. Torry
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Science, 1989
The expression of proto-oncogenes representative of several functional categories has been investigated during development of mouse male germ cells. The c-raf proto-oncogene and three members of the c-ras gene family were expressed in mitotically active ...
Heiner Wolfes +3 more
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The expression of proto-oncogenes representative of several functional categories has been investigated during development of mouse male germ cells. The c-raf proto-oncogene and three members of the c-ras gene family were expressed in mitotically active ...
Heiner Wolfes +3 more
semanticscholar +1 more source
Medical Hypotheses, 1988
In reviewing recent literature on activated proto-oncogenes including retroviral infection (without oncogene), translocation and inherited childhood cancer, I have come to the conclusion that activated proto-oncogenes are not involved in development of tumors. There is one exception in which a translocated proto-myc leads to transformation. That is the
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In reviewing recent literature on activated proto-oncogenes including retroviral infection (without oncogene), translocation and inherited childhood cancer, I have come to the conclusion that activated proto-oncogenes are not involved in development of tumors. There is one exception in which a translocated proto-myc leads to transformation. That is the
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Activation of proto-oncogenes: an immediate early event in human cytomegalovirus infection.
Science, 1990A rapid increase in the RNA levels of the proto-oncogenes c-fos, c-jun, and c-myc was detected after human cytomegalovirus infection. Neither inactivation of viral infectivity with ultraviolet irradiation (with or without psoralen), nor inhibition of ...
Istran Boldogh +2 more
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American Review of Respiratory Disease, 1990
The development of human lung cancer may require multiple genetic deletions affecting a number of chromosomes, e.g., 1, 3, 11, 13, and 17. These genetic aberrations may induce the activation of proto-oncogenes (c-jun, ras, c-raf1) and the loss of tumor ...
J. Bergh
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The development of human lung cancer may require multiple genetic deletions affecting a number of chromosomes, e.g., 1, 3, 11, 13, and 17. These genetic aberrations may induce the activation of proto-oncogenes (c-jun, ras, c-raf1) and the loss of tumor ...
J. Bergh
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Proto-Oncogenes And Cardiac Hypertrophy
Annual Review of Physiology, 1989Generalized or focal myocardial hypenrophy is a component of most types of cardiac disease. Abnormalities of this growth process, which include in adequate, idiopathic, and pathological hypertrophy, have great clinical sig nificance. Postnatal heart enlargement is produced largely by increased size of striated muscle cells (hypertrophy) and increased
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The RET proto‐oncogene and cancer
Journal of Internal Medicine, 1995Abstract. The RET proto‐oncogene, a receptor tyrosine kinase, has been evaluated as a candidate gene for multiple endocrine neoplasia type 2A and type 2B (MEN 2A and MEN 2B), for familial medullary thyroid carcinoma (FMTC), and for sporadic cases of medullary thyroid carcinoma (MTC) and pheochromocytomas. We determined the genomic structure of RET and
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Proto-oncogenes and differentiation
Trends in Biochemical Sciences, 1986Abstract Since their discovery, the cellular homologues of retroviral oncogenes have been presumed to play a role in growth control, mainly because of their potential to induce uncontrolled cellular proliferation. This notion is now strongly supported by evidence that the products of several proto-oncogenes are either growth factors or growth factor ...
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Transcriptional autoregulation of the proto-oncogene fos [PDF]
Nature, 1988 Serum-induced transcription of the proto-oncogene fos is under negative feedback regulation mediated by the fos protein. The fos promoter region responsive to repression is also required for serum inducibility and binds a nucleoprotein complex in which the nuclear factor AP-1 is associated with fos protein.
Inder M. Verma +2 more
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1988
Retroviral oncogenes originally were derived from genes in eukaryotic cells. The seminal discovery that DNA sequences within normal, uninfected, nonmalignant cells were homologous to retroviral oncogenes was made in 1976. Cellular proto-oncogenes have exon and intron structures typical of eukaryotic genes.
Kathy B. Burck +2 more
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Retroviral oncogenes originally were derived from genes in eukaryotic cells. The seminal discovery that DNA sequences within normal, uninfected, nonmalignant cells were homologous to retroviral oncogenes was made in 1976. Cellular proto-oncogenes have exon and intron structures typical of eukaryotic genes.
Kathy B. Burck +2 more
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