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The significance of proto-oncogenes in carcinogenesis
Medical Hypotheses, 1987A survey of the literature on activated proto-oncogenes shows that they are involved in the development of cancer but apparently not in the initiation process. The review of Klein and Klein comes to conclusions in opposition to the review of Duesberg. I favor the latter here.
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Proto-Oncogenes and Human Cancers
New England Journal of Medicine, 1987The idea that specific genes or groups of genes are responsible for the induction or maintenance of cancer is by no means new. Recent research efforts to understand such genetic sequences have focused on the study of cellular oncogenes or proto-oncogenes.
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Proto‐oncogenes in cell differentiation
BioEssays, 1990AbstractProto‐oncogene products may be multi‐functional proteins with various roles in cell differentiation as well as cell proliferation. The molecular biology of the gene products of three well characterized proto‐oncogenes (c‐fos, c‐myc and c‐src) are described, and the roles of three other proto‐oncogene products, involved in hormone and growth ...
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1988
Retroviral oncogenes originally were derived from genes in eukaryotic cells. The seminal discovery that DNA sequences within normal, uninfected, nonmalignant cells were homologous to retroviral oncogenes was made in 1976. Cellular proto-oncogenes have exon and intron structures typical of eukaryotic genes.
Kathy B. Burck +2 more
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Retroviral oncogenes originally were derived from genes in eukaryotic cells. The seminal discovery that DNA sequences within normal, uninfected, nonmalignant cells were homologous to retroviral oncogenes was made in 1976. Cellular proto-oncogenes have exon and intron structures typical of eukaryotic genes.
Kathy B. Burck +2 more
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Proto-oncogenes and differentiation
Trends in Biochemical Sciences, 1986Abstract Since their discovery, the cellular homologues of retroviral oncogenes have been presumed to play a role in growth control, mainly because of their potential to induce uncontrolled cellular proliferation. This notion is now strongly supported by evidence that the products of several proto-oncogenes are either growth factors or growth factor ...
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The pathobiology of proto-oncogenes.
Princess Takamatsu symposia, 1988The search for genetic damage in neoplastic cells now occupies a central place in cancer research. Diverse examples of such damage are in hand, and they in turn hint at biochemical explanations of why cancer cells go astray. The way may be open to solve the riddles of how normal cells govern their replication and why cancer cells do not.
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