Results 191 to 200 of about 111,107 (240)
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Proto‐Oncogenes in Development and Cancer
American Journal of Reproductive Immunology, 1991ABSTRACT: Although analogies are often made comparing development to cancer, there is of course a major difference. Normal development requires complex patterns of rigidly controlled cell proliferation and differentiation. In contrast, cancer represents the pathological condition that results when normal cell growth patterns are uncoupled from their ...
Geoffrey M Cooper
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Tetraphenylethene Derivatives Modulate the RNA Hairpin‐G‐Quadruplex Conformational Equilibria in Proto‐oncogenes** [PDF]
ChemBioChem, 2022 RNA G-quadruplexes (GQs) sequence in 5\u27 UTRs of certain proto-oncogenes colocalize with hairpin (Hp) forming sequence resulting in intramolecular Hp-GQ conformational equilibria which is suggested to regulate cancer development and progression.
Sheshanath Bhosale
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Journal of Cellular Physiology, 1983
The discovery that normal cells contain proto-oncogenes--genes that are analogous to known viral oncogenes--may provide a shortcut not only to understanding some of the pathophysiologic mechanisms that must be involved in carcinogenesis but also to dissecting the processes of normal cell growth and of the evolutionarily developed controls on such ...
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The discovery that normal cells contain proto-oncogenes--genes that are analogous to known viral oncogenes--may provide a shortcut not only to understanding some of the pathophysiologic mechanisms that must be involved in carcinogenesis but also to dissecting the processes of normal cell growth and of the evolutionarily developed controls on such ...
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Leukemia & Lymphoma, 1997
The mouse double minute 2 (mdm2) proto-oncogene was originally discovered as one of three genes that was amplified in a tumorigenic cell line derived from non-transformed Balb/c cells. Consistent with the expression pattern of mdm2 in these cells, it was later shown that the transforming potential of the mdm2 proto-oncogene can be activated by ...
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The mouse double minute 2 (mdm2) proto-oncogene was originally discovered as one of three genes that was amplified in a tumorigenic cell line derived from non-transformed Balb/c cells. Consistent with the expression pattern of mdm2 in these cells, it was later shown that the transforming potential of the mdm2 proto-oncogene can be activated by ...
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Medical Hypotheses, 1988
In reviewing recent literature on activated proto-oncogenes including retroviral infection (without oncogene), translocation and inherited childhood cancer, I have come to the conclusion that activated proto-oncogenes are not involved in development of tumors. There is one exception in which a translocated proto-myc leads to transformation. That is the
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In reviewing recent literature on activated proto-oncogenes including retroviral infection (without oncogene), translocation and inherited childhood cancer, I have come to the conclusion that activated proto-oncogenes are not involved in development of tumors. There is one exception in which a translocated proto-myc leads to transformation. That is the
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Proto-Oncogenes And Cardiac Hypertrophy
Annual Review of Physiology, 1989Generalized or focal myocardial hypenrophy is a component of most types of cardiac disease. Abnormalities of this growth process, which include in adequate, idiopathic, and pathological hypertrophy, have great clinical sig nificance. Postnatal heart enlargement is produced largely by increased size of striated muscle cells (hypertrophy) and increased
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A function for the lck proto-oncogene
Trends in Biochemical Sciences, 1989Proto-oncogenes encode products that comprise a select group of cellular regulatory proteins whose mutation or aberrant expression can result in oncogenic transformation. With the exception of certain growth factors and their receptors, the definition of normal functions for most proto-oncogene products has been elusive.
J B, Bolen, A, Veillette
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Proto-oncogenes and cardiac development
Trends in Cardiovascular Medicine, 1992Proto-oncogene products participate in signaling processes that extend from the cell surface to the nucleus. Recent investigations have focused attention on the role that proto-oncogenes play in the proliferation, differentiation, and hypertrophic growth of cardiac myocytes.
N V, Matiuck, J L, Swain
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Proto-oncogenes in mammalian development
Current Biology, 1992The phenotypic analysis of mice carrying germline mutations in protooncogenes is beginning to provide convincing genetic evidence for the important role that these genes play in mammalian development and differentiation. Two approaches are being taken to elucidate the biological function of proto-oncogenes in vivo.
L M, Forrester, M, Brunkow, A, Bernstein
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The RET proto‐oncogene and cancer
Journal of Internal Medicine, 1995Abstract. The RET proto‐oncogene, a receptor tyrosine kinase, has been evaluated as a candidate gene for multiple endocrine neoplasia type 2A and type 2B (MEN 2A and MEN 2B), for familial medullary thyroid carcinoma (FMTC), and for sporadic cases of medullary thyroid carcinoma (MTC) and pheochromocytomas. We determined the genomic structure of RET and
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