Results 101 to 110 of about 8,829,513 (345)
FEBS Letters, EarlyView.The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li +2 more
wiley +1 more source
Arquivos de Neuro-Psiquiatria, 1996 Os autores apresentam considerações a respeito dos conceitos de morte e morte encefálica, bem como dos aspectos legais para o seu diagnóstico no Brasil.
Venâncio Pereira Dantas Filho +5 more
doaj +1 more source
The Bitcoin Backbone Protocol: Analysis and Applications
International Conference on the Theory and Application of Cryptographic Techniques, 2015 Bitcoin is the first and most popular decentralized cryptocurrency to date. In this work, we extract and analyze the core of the Bitcoin protocol, which we term the Bitcoin backbone, and prove three of its fundamental properties which we call Common ...
J. Garay, A. Kiayias, Nikos Leonardos
semanticscholar +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Integrative Medicine Research, 2016 Introduction: This study aims to demonstrate the effectiveness of using clinical practice guideline (CPG) leaflets as a communication tool between doctors and patients.
Ju Ah Lee +5 more
doaj +1 more source
FEBS Letters, EarlyView.Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson +7 more
wiley +1 more source
Security of Quantum Key Distribution with Coherent States and Homodyne Detection
, 2003 We assess the security of a quantum key distribution protocol relying on the transmission of Gaussian-modulated coherent states and homodyne detection. This protocol is shown to be equivalent to a squeezed state protocol based on a CSS code construction,
A. Steane +5 more
core +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
, 2018 This document details the protocol to execute an empirical study about the industrial practices in model-driven development, focusing in the particular topic of handling non-functional requirements. The empirical study described in this document is a multinational (Europe-wide) survey based on interviews to practitioners.
Ameller, David +20 more
openaire +1 more source
The ODD protocol: A review and first update
Ecological Modelling, 2010 The ‘ODD’ (Overview, Design concepts, and Details) protocol was published in 2006 to standardize the published descriptions of individual-based and agent-based models (ABMs).
V. Grimm +5 more
semanticscholar +1 more source