Results 111 to 120 of about 1,022,619 (266)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Bicycle Helmet STAR Protocol

, 2018
This document details the protocol used to rate adult bicycle helmets based on concussion risk according to the Virginia Tech Helmet ...
McNally, Craig, Bland, Megan L., Rowson, Steven   +2 more
core  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The Kyoto Protocol: A Review and Perspectives [PDF]

International concern about climate change has led to the Kyoto Protocol, negotiated in 1997, which contains legally binding emission targets for industrialized countries to be achieved during the commitment period 2008-2012.
Böhringer, Christoph
core  

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source

A Systems Thinking Approach for Creating Super Clinicians Using a Competency-based Medical Education Framework

Sudan Journal of Medical Sciences, 2020
Imad Hassan, MD (UK) FACP FRCPI MemAcadMEd (UK), MSc (UK), MBBS   +3 more
doaj   +1 more source

A Protocol for When Social Media Goes Private: Studying archaeological or heritage discourses in closed Facebook groups

Internet Archaeology
Our major project explores the discourses that surround the buying and selling of human remains over social media. We discuss the research ethics framework established in Canada by the 'Tri-Council' research agencies as it pertains to studying social ...
Katherine Davidson, Shawn Graham, Damien Huffer   +2 more
doaj   +1 more source

Efficient Transport Protocol for Networked Haptics Applications

, 2008
The performance of haptic application is highly sensitive to communication delays and losses of data. It implies several constraints in developing networked haptic applications.
Wirz, Raul, Marin, Raul, Ortego la Moneda, Javier, Barrio Gragera, Jorge, Ferre Pérez, Manuel, Claver, Jose M.   +5 more
core  

Protocols for clinical use at Nature Protocols [PDF]

Nature Protocols, 2021
openaire   +2 more sources