Results 131 to 140 of about 1,022,619 (266)

Protocol or Performance

Journal of the American College of Cardiology, 2013
Out-of-hospital sudden cardiac arrest (SCA) is a leading cause of mortality in industrialized societies ([1][1]). Thus, even modest improvements in collective survival could meaningfully advance public health.
openaire   +2 more sources

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Impact of the Pre-Operative Standardized Nutritional Protocol in Infants with Congenital Heart Disease (CHD)

Journal of Cardiovascular Development and Disease
Neonates with congenital heart disease (CHD) are at increased risk of growth failure and necrotizing enterocolitis (NEC), making nutritional management crucial for their outcomes. This study aimed to evaluate the impact of a standardized feeding protocol
Patrick Zacharias, Jenna Blinci, Ruthie Shenoy, Jesse Lee, Yogen Singh   +4 more
doaj   +1 more source

Protocol-directed sedation versus non-protocol-directed sedation in mechanically ventilated intensive care adults and children

, 2018
Protocol-directed sedation versus non-protocol-directed sedation in mechanically ventilated intensive care adults and ...
Bridie Kent (13062015), SJ Keogh (14460237), M Mitchell (9861551), E Burmeister (9891191), Tracey Bucknall (13098153), LM Aitken (14460234)   +5 more
core  

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Critiques protocolaires d’Internet : comparaison des projets IPFS et SecureScuttleButt

Tic & Société
This article highlights the political a priori and debates around two critical infrastructures proposed as alternatives to current Internet protocols: the IPFS (Interplanetary File System) and SSB (SecureScuttlebutt). Using critical discourse analysis to
Pierre DEPAZ
doaj   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Protocol for the first cycle of the Collaborative Open Research Initiative Study (CORIS-1): An international survey of personnel in health professions schools in 16 countries

Population Medicine
The Collaborative Open Research Initiative Study (CORIS) is an inclusive and innovative international research project that welcomes contributors from across the globe.
Israel Agaku, Lungile Nkosi, Muath Aldosari, Enihomo Obadan, Oluwakemi Odukoya, Weifang Zhang, Hend Alqaderi, Erinne N. Kennedy, Constantine Vardavas, Olalekan Ayo-Yusuf   +9 more
doaj   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source