Results 121 to 130 of about 4,819,126 (312)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Effect of acupuncture on episodic memory for amnestic mild cognitive impairment based on hippocampal subregion: study protocol of a randomized, controlled trial

Frontiers in Neurology
BackgroundThe hippocampus is a key brain region for episodic memory, and impairment of episodic memory is the earliest feature of amnestic mild cognitive impairment (aMCI).
Xinbei Li, Xingying Lu, Juan Ou, Hanqing Lyu, Yongfeng Liu, Jinhuan Zhang   +5 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Acupuncture for arousal combined with repetitive transcranial magnetic stimulation promotes functional reorganization of brain regions in patients with a minimally conscious state: study protocol for a randomized controlled trial

Frontiers in Neurology
IntroductionThe minimally conscious state (MCS) is one of the common and serious complications of stroke patients. Its incidence is higher than that of other types of consciousness disorders.
Jiajia Li, Hongjing Fang, Tong Liu, Tong Liu, Peixin Li, Zhihong Ou, Zhihui Li, Tao Huang, Juan Sun, Jueyu Zhang, Jueyu Zhang, Fangyi Lu, Fangyi Lu, Xi Wen, Xi Wen   +14 more
doaj   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

STAR Protocol for Construction Helmets [PDF]

This document details the protocol used to rate construction helmets based on concussion risk according to the Virginia Tech Helmet Ratings.Corrected version 2025-10 ...
Gagliardi, Susanna M., Stark, Nicole, Begonia, Mark T., Edwards, Lee M., Rowson, Steven   +4 more
core  

A Data-Driven Approach to Revolutionize Children’s Vaccination with the Use of VR and a Novel Vaccination Protocol

BioMedInformatics
Background: This study aims to revolutionize traditional pediatric vaccination protocols by integrating virtual reality (VR) technology. The purpose is to minimize discomfort in children, ages 2–12, during vaccinations by immersing them in a specially ...
Stavros Antonopoulos, Manolis Wallace, Vassilis Poulopoulos   +2 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Shuhe granule for insomnia: study protocol for a double-blind, randomized, placebo-controlled trial

Frontiers in Pharmacology
IntroductionModern medical treatment of insomnia is often associated with issues like addiction, drug resistance, and a high risk of relapse post drug withdrawal.
Yu Gao, Xiangbin Chen, Yuxi Li, Yuchuan Shen, Xinyi Chen, Qing Xu, Mengling Peng, Wen Xu, Jiamin Yuan, Yuanyuan Hu, Xiankun Chen, Xiankun Chen, Biyun Xu, Biyun Xu, Zhimin Yang   +14 more
doaj   +1 more source

Functional comparison of EncB and EncC cargo proteins in iron storage within the Myxococcus xanthus encapsulin

FEBS Letters, EarlyView.
Encapsulins are protein nanocompartments that play an important role in iron storage. In the Myxococcus xanthus encapsulin system, two cargo proteins called EncB and EncC contribute to iron mineralization. Here, we show that EncB and EncC generate iron‐containing minerals with distinct chemical compositions, suggesting that the composition of stored ...
Harry B. McDowell, Thomas Walther, Egbert Hoiczyk   +2 more
wiley   +1 more source