Results 121 to 130 of about 2,462,286 (267)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Figs. 14–15 in "Berlese vs. Winkler": Comparison of Two Forest Litter Coleoptera Extraction Methods and the Ecoli (Extraction of Coleoptera in Litter) Protocol

, 2015
Figs. 14–15. Number of Coleoptera specimens obtained at predetermined time intervals in two trials to test ECOLI protocol. 14) Trial A, Coleoptera specimens obtained from Berleses and Winklers at the initial 24-hr interval, during the intermediate ...
Carlton, Christopher E., Owens, Brittany E.   +1 more
core   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Effects of Different Numbers of Trials on Saccadometry Test Results

Brain and Behavior
Purpose The aim of this study was to investigate the effect of the number of trials on the recording in the saccadometry test. Method Forty‐five healthy participants (mean age ± SD = 25.89 ± 5.2 years) (31 female and 14 male) aged 19–40 years were ...
Aysenur Kucuk Ceyhan, Asya Fatma Men, Zahra Polat   +2 more
doaj   +1 more source

Emergence in the security of protocols for mobile ad-hoc networks [PDF]

This thesis is concerned with the study of secure wireless routing protocols, which have been deployed for the purpose of exchanging information in an adhoc networking enviromnent.
Pavlosoglou, Ioannis
core  

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Research routing and MAC based on LEACH and S-MAC for energy efficiency and QoS in wireless sensor network

The wireless sensor is a micro-embedded device with weak data processing capability and small storage space. These nodes need to complete complex jobs, including data monitoring, acquisition and conversion, and data processing.
Long, Hua
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Effectiveness of the U-Niko intervention: Protocol for a cluster randomized controlled trial of a municipal-based tobacco and nicotine cessation intervention for adolescents and young adults.

PLoS ONE
IntroductionThe use of nicotine products among youth is increasing, while existing cessation services remain underutilized. Thus, the U-Niko intervention has been developed to provide an evidence-based, youth-oriented approach for effective nicotine ...
Sofie Bergman Rasmussen, Christina Bjørk Petersen, Mette Rasmussen, Nina Kamstrup-Larsen, Charlotta Pisinger   +4 more
doaj   +1 more source