Results 131 to 140 of about 1,023 (167)
Methyl Protodioscin Induces G2/M Cell Cycle Arrest and Apoptosis in HepG2 Liver Cancer Cells
Cancer Letters, 2006 Methyl protodioscin (NSC-698790) is one of the main bioactive components in the traditional Chinese medicine Dioscorea collettii var. hypoglauca (Dioscoreaceae).
Da-Peng Qin, Jinchao Zhang, HaiFeng Chen
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Pharmacokinetics of methyl protodioscin in rats
Die Pharmazie, 2010Methyl protodioscin (MPD), a natural furostanol saponin, showed distinct antitumor activity and is distributed in many traditional Chinese medicines. The pharmacokinetics, distribution and excretion of MPD were first investigated after i.v. injection to rats in this study.
Yao, Z., Cao, X., Shao, M., et al.
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Ameliorative Effects of Protodioscin on Experimental Diabetic Nephropathy
Phytomedicine, 2018Diabetic nephropathy is one of the most common and serious complications of diabetes mellitus.The present study aimed to investigate the effects of protodioscin on renal damage in high-fat diet-fed and streptozotocin-induced diabetic rats.After 4 weeks of feeding a high-fat diet, male Sprague-Dawley rats were injected 35 mg/kg streptozotocin ...
Guoyong Xie
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Natural intoxication caused by protodioscin in lambs kept in Brachiaria pastures
Tropical Animal Health and Production, 2021Protodioscin poisoning of Brachiaria spp. has been a serious problem for lambs in grazing systems. The defoliation process can stimulate the appearance of new leaves and, the younger leaves have a lower concentration of protodioscin. Thus, it was aimed to assess the effect of different leaf offerings on the protodioscin content in forage and if ...
Marlova Cristina Mioto da Costa +12 more
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Bioconversion of Methyl Protodioscin by Penicillium Melinii Cells
Enzyme and Microbial Technology, 2006Abstract Bioconversion of methyl protodioscin (1) by Penicillium melinii was investigated. Seven bioconversion products were isolated and identified. Three of them were glycosidation products and were new compounds. Their structures were identified to be 3- O -[α- l -rhamnopyranosyl-(1 → 2)-{α- l -rhamnopyranosyl-(1 → 4)}-β- d -glucopyranosyl]-26 ...
Xiangjiu He, Da-Peng Qin, Rui Hai Liu
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Determination of Protodioscin in Rat Plasma by Liquid Chromatography–Tandem Mass Spectrometry
Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences, 2007Protodioscin (3-O-[alpha-L-rhamnopyranosyl-(1-->2)-{alpha-L-rhamnopyranosyl-(1-->4)}-beta-D-glucopyranosyl]-26-O-[beta-D-glucopyranosyl]-(25 R)-furost-5-ene-3 beta,26-diol) is a naturally occurring saponin present in many oriental vegetables and traditional medicinal plants, which has been associated with potent bioactivity.
Tie-Jie Wang, Xiaohui Chen, Zhongbo Liu
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Microbial Transformation of Methyl Protodioscin by Cunninghamella elegans
Journal of Molecular Catalysis B: Enzymatic, 2005Biotransformation of methyl protodioscin (1) by Cunninghamella elegans (AS 3.1207) was investigated. Nine bioconversion products were isolated and identified. Eight of the bioconversion products were pregnane glycoside or steroidal saponins. It was found that steroidal saponin skeleton could be converted to pregnenolone skeleton only using microbial ...
Zhihong Yao, Xiangjiu He, Da-Peng Qin
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A Simple Method for Determination of Protodioscin in Tribulus terrestris L. and Pharmaceuticals by High-Performance Liquid Chromatography Using Diode-Array Detection [PDF]
Journal of Chemical Engineering Research Updates, 2015 The Tribulus terrestris L. (Zygophyllaceae) is a known medical plant used in traditional and folk medicine worldwide. The steroid saponine protodioscin, an active component found in this plant, serves as a marker for quality control of plant raw ...
Arsova-Sarafinovska, Zorica +2 more
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Aphrodisiac Properties of Tribulus terrestris Extract (Protodioscin) in Normal and Castrated Rats
Life Sciences, 2002Tribulus terrestris (TT) has long been used in the traditional Chinese and Indian systems of medicine for the treatment of various ailments and is popularly claimed to improve sexual functions in man. Sexual behaviour and intracavernous pressure (ICP) were studied in both normal and castrated rats to further understand the role of TT containing ...
R N V Prasad, P G Adaikan
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