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An Improved Synthesis of Methyl Protodioscin: Tautomerization and Direct Access to the 3-O-Substituted Kryptogenin

Chemistry Letters, 2008
Abstract The acid-catalyzed tautomerization of 3-O-substituted kryptogenin 2 was studied, and the effects of acids such as silica gel, TMSOTf, acetic acid, and CDCl3, are discussed. Additionally, a Zn/KI/HOAc reduction based on this tautomerization was adopted, which afforded 2 directly, and provided a facile procedure for the synthesis ...
Qing-Chun Xu   +5 more
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Protodioscin: Current Advances in Phytochemistry, Analytical Characterization, Pharmacology, and Therapeutic Potential

ABSTRACT: Protodioscin is a naturally occurring steroidal saponin found in several medicinal plants, particularly Tribulus terrestris, Dioscorea species, and fenugreek (Trigonella foenum-graecum). Growing interest in protodioscin has led to increasing research on its chemical properties, biological activities, analytical characterization, and ...
A. Bhavana   +6 more
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[Effects of methyl protodioscin on [Ca2+]i and ATPase activity in cardiomyocytes and analysis of mechanisms].

Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica, 2010
To study the effects of methyl protodioscin on the [Ca2+]i and the ATPase activity in cardiomyocytes, as well as their mechanisms.The cardiomyocytes were randomly divided into three groups, the control group treated with no serumal DMEM, the MPD group treated with MPD and the dilthiazem group treated with dilthiazem. Fluorospectrophotometer was used to
Zong, Ning, Yikui, Li, Rongli, Zhang
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Steroidal glycoside-protodioscin from Digitalis ciliata

Chemistry of Natural Compounds, 2006
L. N. Gvazava, V. S. Kukoladze
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[Effect and mechanism of methyl protodioscin in protecting cardiomyocytes against anoxia/reoxygenation injury].

Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine, 2013
To study the effect and mechanism of methyl protodioscin (MPD), an active ingredients of yamogenin, in protecting cardiomyocytes (CMC) against anoxia/reoxygenation (A/R) injury.Cultured CMCs of neonatal SD rats were randomly divided into three groups, cells in Group A were untreated normal cells, cells in Group B and C were made to injury CMC model by ...
Zong, Ning, Yi-kui, Li, Yan, Zhou
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22-Methyl ether of protodioscin from the seeds of Trigonella coerulea

Chemistry of Natural Compounds, 1977
N. G. Bogacheva   +2 more
openaire   +1 more source

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