Results 71 to 80 of about 2,001,633 (378)

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Antiproton-Proton Channels in J/psi Decays

, 2005
The recent measurements by the BES Collaboration of J/psi decays into a photon and a proton-antiproton pair indicate a strong enhancement at the proton-antiproton threshold not observed in the decays into a neutral pion and a proton-antiproton pair.
B. Loiseau, Chong-Shou Gao, H. Pilkuhn, S. Wycech   +3 more
core   +2 more sources

A measurement of the atomic hydrogen Lamb shift and the proton charge radius

Science, 2019
Unraveling the proton puzzle The discrepancy between the proton size deduced from the Lamb shift in muonic hydrogen and the average, textbook value based on regular (electronic) hydrogen has puzzled physicists for nearly a decade. One possible resolution
N. Bezginov, T. Valdez, M. Horbatsch, A. Marsman, A. Vutha, E. A. Hessels   +5 more
semanticscholar   +1 more source

Search for sphalerons in proton-proton collisions [PDF]

Journal of High Energy Physics, 2016
In a recent paper, Tye and Wong (TW) have argued that sphaleron-induced transitions in high-energy proton-proton collisions should be enhanced compared to previous calculations, based on a construction of a Bloch wave function in the periodic sphaleron potential and the corresponding pass band structure.
Kazuki Sakurai, John Ellis, John Ellis
openaire   +7 more sources

Development of visible light‐sensitive human neuropsin (OPN5) via single amino acid substitution

FEBS Letters, EarlyView.
The present study determines a key amino acid residue, Lys91, for defining UV sensitivity of human OPN5. Heterologous action spectroscopy of the wild type and K91 mutants of OPN5 in HEK293T cells reveals that substitution of Lys91 with neutral (alanine) or acidic amino acids (glutamic or aspartic acids) causes substantial shifts in spectral sensitivity
Yusuke Sakai, Richard J. McDowell, Robert J. Lucas   +2 more
wiley   +1 more source

Exploring new frontiers in the pulsed power laboratory: Recent progress

Results in Physics, 2015
One of the most fundamental processes in the Universe, nucleosynthesis of elements drives energy production in stars as well as the creation of all atoms heavier than hydrogen.
S. Adamenko, A. Esaulov, B. Ulmen, V. Novikov, S. Ponomarev, A. Adamenko, V. Artyuh, A. Gurin, V. Prokopenko, V. Kolomiyets, V. Belous, K.-J. Kim, G. Miley, A. Bassuney, D. Novikov   +14 more
doaj   +1 more source

Pencil‐beam scanning proton therapy for the treatment of glomus jugulare tumours

Journal of Medical Radiation Sciences, 2022
Introduction Glomus jugulare tumours (GJT) are benign tumours that arise locally and destructively in the base of the skull and can be successfully treated with radiotherapy.
Jiří Kubeš, Vladimír Vondráček, Michal Andrlik, Matěj Navrátil, Silvia Sláviková, Daniel Klika, Alexandra Haas, Kateřina Dědečková, Kateřina Kopečková, Barbora Ondrová, Eliška Rotnáglová, Štěpán Vinakurau, Alexander Grebenyuk, Jozef Rosina   +13 more
doaj   +1 more source

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

First-in-human trial using mixed-reality visualization for patient setup during breast or chest wall radiotherapy

Radiation Oncology
Background The purpose of this study is to assess the feasibility of mixed-reality (MixR) visualization for patient setup in breast and chest wall radiotherapy (RT) by performing a first-in-human clinical trial comparing MixR with a 3-point alignment ...
Perry B. Johnson, Julie Bradley, Samsun Lampotang, Amanda Jackson, David Lizdas, William Johnson, Eric Brooks, Raymond B. Mailhot Vega, Nancy Mendenhall   +8 more
doaj   +1 more source

Near-Threshold eta Meson Production in Proton-Proton Collisions

, 1999
The production of eta mesons has been measured in the proton-proton interaction close to the reaction threshold using the COSY-11 internal facility at the cooler synchrotron COSY.
A. Budzanowski, A. Khoukaz, A. Strzałkowski, Albers, Balewski, Brauksiepe, C. Quentmeier, Calén, Calén, Chiavassa, D. Grzonka, Dombrowski, G. Schepers, Green, H. Dombrowski, J. Smyrski, J.T. Balewski, K. Kilian, L. Jarczyk, Lee, M. Jochmann, M. Köhler, M. Wolke, Maier, Morton, P. Kowina, P. Moskal, P. Wüstner, R. Santo, S. Sewerin, T. Lister, T. Sefzick, U. Seddik, W. Oelert   +33 more
core   +1 more source