Results 191 to 200 of about 3,469,794 (238)

Impact of collimator misalignments on dosimetric robustness in proton minibeam radiotherapy using an automated measurement setup

Medical Physics, Volume 53, Issue 9, September 2026.
Abstract Background Proton minibeam radiation therapy is an emerging technique that combines the tissue‐sparing benefits of protons with the spatial modulation used for minibeams to reduce toxicity in healthy tissue. Achieving accurate delivery of planned dose distributions depends on precise collimator‐to‐beam alignment, for which it is essential to ...
Sake Salverda, Ernst van der Wal, Thomas Toet, Mischa Hoogeman, Kelvin Ng Wei Siang   +4 more
wiley   +1 more source

Sensitization for proton beam therapy using ¹⁰B enriched and natural isotopic abundance of boronophenylalanine. [PDF]

Sci Rep
Shiba S, Shimo T, Yamanaka M, Sakai M, Ohno T, Tokuuye K, Omura M.   +6 more
europepmc   +1 more source

Identification of a key water molecule involved in the macrophage migration inhibitory factor‐catalyzed tautomerization of para‐hydroxyphenylpyruvate using neutron crystallography

Protein Science, Volume 35, Issue 9, September 2026.
Abstract Neutron crystallography was used to determine a 2.5‐Å resolution all‐atom structure of macrophage migration inhibitory factor (MIF) interacting with 3‐(4‐hydroxyphenyl)‐pyruvate (HPP). MIF is a pro‐inflammatory, pro‐tumorigenic protein that may be an attractive therapeutic target. MIF catalyzes the interconversion of the keto and enol forms of
Gabriela C. Schröder, Gregg V. Crichlow, Ewelina Jablonowski, Georgios Pantouris, Jay Nix, Naomi Chayen, Flora Meilleur, Elias J. Lolis   +7 more
wiley   +1 more source

Offline Plan Adaptation in Robustly Optimized CBCT-Guided Pencil Beam Scanning Proton Beam Therapy: Lessons From a Real-World Cohort. [PDF]

Adv Radiat Oncol
Chilukuri S, Sundar S, Gaikwad U, Arjunan M, Kamath R, Nangia S, Burela N, Krishnan G, Mookaiah M, Shanmugam K, Krishna U, Abhishek A, Sharma DS, Jalali R.   +13 more
europepmc   +1 more source

Structure and conformational dynamics of the Pseudomonas CbrA transceptor

Protein Science, Volume 35, Issue 9, September 2026.
Abstract The CbrA protein is a central regulator of carbon metabolism, biofilm formation, and virulence in Pseudomonas species, but the molecular mechanisms by which CbrA links nutrient sensing to downstream signaling has remained unclear. CbrA is a rare “transceptor” that combines membrane transporter and histidine kinase domains into a single ...
Melanie A. Orlando, Tejas Shah, Matthew W. Faber, Samik Bose, Benjamin J. Orlando   +4 more
wiley   +1 more source

Supersonic gas curtain based ionization beam profile monitor for FLASH proton beam therapy. [PDF]

Front Oncol
Patel M, Kumar N, Thesni F, Butcher W, Price T, McLauchlan R, Welsch CP.   +6 more
europepmc   +1 more source

Radiotherapy and Immunotherapy In Hepatocellular Carcinoma: Priming the Tumor Immune Microenvironment From Bench To Bedside

Precision Radiation Oncology, Volume 10, Issue 3, Page 417-427, September 2026.
The dual immunomodulatory network of radiotherapy in hepatocellular carcinoma. Radiotherapy initiates its effects by inducing immunogenic cell death and DNA double‐strand breaks. Immune Activation: Cytosolic DNA from damaged cells activates the cGAS‐STING pathway, triggering IRF3/NF‐κB‐mediated type I interferon production. This enhances dendritic cell
Zhigang Fu, Yang Zhang, Zuomin Wang, Zongjuan Li, Shisuo Du   +4 more
wiley   +1 more source

Proton Beam Therapy for Untreated Hepatocellular Carcinoma Unsuitable for Transcatheter Arterial Chemoembolization. [PDF]

Liver Cancer
Niitsu H, Makishima H, Hasegawa N, Ikeda T, Iizumi T, Saito T, Numajiri H, Nakai K, Mizumoto M, Okumura T, Sakurai H.   +10 more
europepmc   +1 more source

Safety, efficacy, pharmacokinetics, and mechanisms of novel 10B‐boronophenylalanine combined with a radio‐frequency quadrupole accelerator in boron neutron capture therapy: A preclinical study in head and neck squamous cell carcinoma

Precision Radiation Oncology, Volume 10, Issue 3, Page 333-346, September 2026.
This study demonstrates that the novel 10B‐BPA‐based BNCT system, combined with an RFQ accelerator, effectively targets head and neck squamous cell carcinoma. It induces tumor regression safely and efficiently by triggering DNA damage and activating the ROS/HIF‐1α/NF‐κB pathway, leading to caspase‐3‐mediated apoptosis.
Zhaoyuan Zhang, Junyan Li, Minhua Fan, Huafu Ouyang, Qiubo Chu, Huijie Yan, Yannan Zheng, Linxuan Huang, Gui Bao, Zhenting Ma, Shaobo Huang, Lin Li, Xiao Xu, Zhigang Liu   +13 more
wiley   +1 more source

Normal tissue complication probability models of late cardiopulmonary toxicity following deep inspiration breath hold for breast cancer adjuvant radiotherapy

Precision Radiation Oncology, Volume 10, Issue 3, Page 307-318, September 2026.
Deep inspiration breath hold (DIBH) markedly cuts heart and left lung radiation doses during left‐sided breast cancer radiotherapy. The normal tissue complication probability (NTCP) model further confirms lower predicted cardiopulmonary toxicities versus free breathing (FB), potentially improving patients’ quality of life.
Lin Lin, Liang Liu, Zhengxin Gao, Yaling Hong, Qing Gong, Zhan Yu, Xue Liu, Qiaoying Hu, Yongqiang Li, Shen Fu, Qi Yu   +10 more
wiley   +1 more source