Results 141 to 150 of about 125,484 (349)
Associations between gastro-oesophageal reflux, its management and exacerbations of chronic obstructive pulmonary disease [PDF]
, 2015 To determine factors, overall and by sex, associated with self-reported gastro-oesophageal reflux disease (GORD) in chronic obstructive pulmonary disease (COPD) patients, and to evaluate relationships between GORD, its modification by acid suppression ...
Benson, VS +5 more
core
Single‐Cell RNA Sequencing Delineates Renal Anti‐Fibrotic Mechanisms Mediated by TRPC6 Inhibition
Advanced Science, EarlyView.Single‐cell transcriptomics reveals how TRPC6 inhibition alters renal cell composition and gene expression in CKD. The study uncovers a novel endothelial subpopulation (ECRIN), highlights key inflammatory and fibrotic pathways, and identifies a Prnp‐driven network linked to fibrosis resolution, offering mechanistic insight into TRPC6 as a potential ...
Yao Xu +12 more
wiley +1 more source
A new mechanism for anti‐inflammatory actions of proton pump inhibitors – inhibitory effects on neutrophil–endothelial cell interactions [PDF]
, 2000 N. Yoshida +6 more
openalex +1 more source
Advanced Science, EarlyView.Epidemiological data confirm obesity elevates thoracic aortic dissection (TAD) risk. Patient analyses implicate hyperleptinemia, where leptin binding to vascular smooth muscle cell (VSMC) receptors triggers Socs3‐mediated suppression of Stat5a transcriptional activity.
Ling Chen +18 more
wiley +1 more source
High dose proton pump inhibitor response as an initial strategy for a clinical diagnosis of gastro-oesophageal reflux disease (GERD) [PDF]
, 2000 J Brun, Heléne Sörngård
openalex +1 more source
Advanced Science, EarlyView.Schematic model of CJP–TiN liposomes for gastric cancer (GC) treatment. Internalizing RGD peptide (iRGD) targets tumor cells, while Chlorin e6 (Ce6) generates reactive oxygen species (ROS). Jolkinolide B (JB) activates the PANoptosis pathway via caspase‐8, enhancing GC cell death and immune response, transforming “cold tumors” into “hot tumors” by ...
Chenhui Ma +14 more
wiley +1 more source
Proton Pump Inhibitors: Omeprazole [PDF]
, 2014 Characteristics and uses of proton pump inhibitors are discussed, specifically, the drug omeprazole, a type of proton pump inhibitor, is discussed, including the chemistry, it\u27s uses and side ...
Ongkowijoyo, Paulina N
core +1 more source
Advanced Science, EarlyView.This study develops a human engineered heart tissue‐derived model of diabetic cardiomyopathy that accurately replicates the dynamic changes in the structural, contractile, and electrophysiological properties of the myocardium. Furthermore, this model is used to confirm the direct protective effects of empagliflozin on the heart through an SGLT2 off ...
Lin Cai +9 more
wiley +1 more source