Results 91 to 100 of about 260,677 (342)

RBE-weighted dose conversions for patients with recurrent nasopharyngeal carcinoma receiving carbon-ion radiotherapy from the local effect model to the microdosimetric kinetic model

Radiation Oncology, 2020
Background We sought to establish a conversion curve to convert the RBE-weighted doses calculated by local effect model I (LEM) (LEM RBE-weighted doses) in patients with locally recurrent nasopharyngeal carcinoma (rNPC) to the RBE-weighted doses ...
Liwen Zhang, Weiwei Wang, Jiyi Hu, Jiade Lu, Lin Kong   +4 more
doaj   +1 more source

Particle Beam Radiation Therapy for Adenoid Cystic Carcinoma of the Nasal Cavity and Paranasal Sinuses

Frontiers in Oncology, 2020
Background: Sinonasal adenoid cystic carcinoma (SNACC) presents a challenge to oncologists due to its complex anatomy and poor prognosis. Although radiation therapy, either definitive or adjuvant to surgery, is an important part of the multidisciplinary ...
Weixu Hu, Weixu Hu, Jiyi Hu, Jiyi Hu, Qingting Huang, Qingting Huang, Jing Gao, Jing Gao, Jing Yang, Jing Yang, Xianxin Qiu, Xianxin Qiu, Lin Kong, Lin Kong, Jiade J. Lu, Jiade J. Lu   +15 more
doaj   +1 more source

Fast Neutron Detector Based on Hybrid 2D Perovskite Thin Films

Advanced Functional Materials, EarlyView.
This work presents the direct detection of fast neutrons using flexible hybrid 2D perovskite (PEA2PbBr4) thin‐film detectors. Thanks to their high low‐Z elements content and good charge transport, these materials enable efficient neutron detection. The thin film configuration allowed the operation at low voltage, and offer scalability, flexibility, and
Ilaria Fratelli, Felix Pino, Laura Basiricò, Giulia Napolitano, Jessica Carolina Delgado, Sara Cepić, Andrea Ciavatti, Sandra Moretto, Gianluigi Maggioni, Marco Cinausero, Sara Maria Carturan, Beatrice Fraboni   +11 more
wiley   +1 more source

Standard operating procedure (SOP) for immobilisation, scanning, verification and treatment of breast cancer patients undergoing proton beam therapy

Technical Innovations & Patient Support in Radiation Oncology
The use of proton beam therapy (PBT) for breast cancer is not currently included for standard consideration on the NHS England indication list. However, there are occasions where the use of PBT may be approved in the United Kingdom (UK), such as breast ...
Kathryn Osborn, Jaymisha Davda, Rita Simoes, Michael O’Connor, Olivia Willis, Sarah Gulliford, Syed Ali Moinuddin, Turmi Patel, Sarah Petty, Mahbubl Ahmed, Thomas Richards, Sairanne Wickers   +11 more
doaj   +1 more source

Foundation of an analytical proton beamlet model for inclusion in a general proton dose calculation system

, 2010
We have developed a model for proton depth dose and lateral distributions based on Monte Carlo calculations (GEANT4) and an integration procedure of the Bethe-Bloch equation (BBE).
B. Schaffner, Bethe, Bethe, Bloch, Bortfeld, Carlsson, Carlsson, Ciangaru, Deasy, Fippel, Gottschalk, Hollmark, Hong, Jiang, Kusano, Matsuura, Medin, Paganetti, Pedroni, Petti, Russel, Sandison, Sandison, Schaffner, Schaffner, Schneider, Segrè, Szymanowski, Tourovsky, Ulmer, Ulmer, W. Ulmer   +31 more
core   +1 more source

Machine Learning‐Enabled Polymer Discovery for Enhanced Pulmonary siRNA Delivery

Advanced Functional Materials, EarlyView.
This study provides an efficient approach to train a machine learning model by merging heterogeneous literature data to predict suitable polymers for siRNA delivery. Without the need for extensive laboratory synthesis, the machine learning enabled a virtual screening and successfully predicted a polymer that is validated for effective gene silencing in
Felix Sieber‐Schäfer, Min Jiang, Adrian Kromer, Anny Nguyen, Müge Molbay, Simone Pinto Carneiro, David Jürgens, Gerald Burgstaller, Bastian Popper, Benjamin Winkeljann, Olivia Monika Merkel   +10 more
wiley   +1 more source

The scenario-based generalization of radiation therapy margins

, 2015
We give a scenario-based treatment plan optimization formulation that is equivalent to planning with geometric margins if the scenario doses are calculated using the static dose cloud approximation.
Bokrantz, Rasmus, Fredriksson, Albin
core   +1 more source

Adalimumab‐Poloxamer Conjugate for Bio‐Better: Enhanced Stability and Function

Advanced Functional Materials, EarlyView.
Antibody‐polymer conjugates, particularly poloxamer conjugates, enhance antibody stability by improving tolerance to physicochemical stress and attenuating proteolysis by proteases. Furthermore, the higher affinity observed with poloxamer conjugation compared to standard PEGylation results in improved therapeutic efficacy in rheumatoid arthritis mouse ...
Jaewon Roh, Sanghee Lee, Soomin Cho, Kun Na   +3 more
wiley   +1 more source

Respiratory-gated proton beam therapy for intrahepatic cholangiocarcinoma without fiducial markers

Radiation Oncology
Background Intrahepatic cholangiocarcinoma (ICC) is a challenging primary liver cancer with a poor prognosis, especially in unresectable cases. Traditional palliative irradiation is limited in reducing liver doses.
Akihito Okubo, Sae Matsumoto, Hiroyasu Tamamura, Yoshitaka Sato, Satoko Asahi, Hitoshi Tatebe, Kazutaka Yamamoto, Keiichiro Matsushita, Makoto Sasaki, Yoshikazu Maeda, Yuji Tameshige, Hajime Sunagozaka, Hiroyuki Aoyagi, Satoshi Shibata, Shigeyuki Takamatsu, Satoshi Kobayashi   +15 more
doaj   +1 more source

Endocytic Programming via Porous Silicon Nanoparticles Enhances TLR4 Nanoagonist Potency for Macrophage‐Mediated Immunotherapy

Advanced Functional Materials, EarlyView.
Porous silicon nanoparticles (PSiNPs) reprogram macrophage endocytosis of manganese@albumin‐based TLR4 nanoagonists, driving TRIF‐biased TLR4 signaling, eliciting robust proinflammatory responses, and potentiating macrophage‐mediated immunotherapeutic effects against NSCLC.
Xiaomei Zhang, Huiying Li, Shuodan Huang, Linxuan Zhang, Yan Gao, Ruoran Wang, Xiaoyu Wang, Hélder A. Santos, Zhenyu Yin, Bing Xia   +9 more
wiley   +1 more source