Results 111 to 120 of about 147,513 (305)

Dosimetric and On-treatment Clinical Results of a Volumetric-based Skin-sparing Planning Technique for Patients Treated to the Breast and Chest Wall With Pencil-Beam Scanning Proton Therapy

Advances in Radiation Oncology
Purpose: This study evaluates the hypothesis that a volumetric skin-sparing planning technique (SSPT) will reduce acute dermatitis in patients treated to the breast or chest wall (CW) with proton pencil-beam scanning (PBS).
Avani D. Rao, MD, Alexander Goughenour, CS, CMD, Betelehem Kebede, BS, Caroline Bamberger, BS, Grayden MacLennan, MS, CMD, Jackeline Castro, BS, CMD, Lisa Stephenson, MS, CMD, Amanuel Negussie, MS, CMD, Sydney Seracino, CMD, Hongkun Wang, PhD, Stella Hetelekidis, MD, Sarah J. Gao, MD, Lonika Majithia, MS, MD, Ashish Chawla, MD, Ashkan Parniani, MBA, CMD, Peng Wang, PhD, DABR, Jiajin Fan, PhD, DABR   +16 more
doaj   +1 more source

Perivascular Matrix Densification Dysregulates Angiogenesis and Activates Pro‐Inflammatory Endothelial Cells

Advanced Science, EarlyView.
Perivascular matrix densification promotes the emergence of aberrant endothelial tip cells (ATECs) that invade and persist within fibrotic microenvironments. Using in vivo lineage tracing and a human microvessel model, this study shows that fibrous matrix cues destabilize VE‐cadherin–mediated junctions to gate TGF‐β signaling, inducing a pro ...
Jingyi Xia, William Y. Wang, Kyle A. Jacobs, Kairav Maniar, Daphne Lin, Evan H. Jarman, Daniel L. Matera, Kristen Loesel, Christopher D. Davidson, Harrison L. Hiraki, Xiaotian Tan, Eve H. Shikanov, Robert N. Kent, Carole Parent, Xudong Fan, Ariella Shikanov, Matthew L. Kutys, Brendon M. Baker   +17 more
wiley   +1 more source

A critical appraisal of the clinical utility of proton therapy in oncology

, 2015
Dongxu WangDepartment of Radiation Oncology, University of Iowa Hospitals and Clinics, Iowa City, IA, USAAbstract: Proton therapy is an emerging technology for providing radiation therapy to cancer patients.
Wang D
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Targeting UXS1‐Dependent Glucuronate Detoxification Potentiates Metformin's Anti‐Tumor Efficacy in Lung Adenocarcinoma

Advanced Science, EarlyView.
This study reveals that metformin promotes glucuronic acid metabolism in lung adenocarcinoma by activating UGDH S476 phosphorylation and enhancing the conversion of UDPG to UDPGA based on metabolomics analysis. Through compound virtual screening, it is found that plantainoside targeting UGDH downstream UXS1 leads to UDPGA toxicity accumulation ...
Qihai Sui, Zhencong Chen, Guangyao Shan, Zhengyang Hu, Xing Jin, Jiaqi Liang, Yanjun Yi, Jiacheng Yin, Haochun Shi, Xifei Jiang, Junjie Xi, Zongwu Lin, Cheng Zhan, Fenghao Sun, Wei Jiang   +14 more
wiley   +1 more source

Proton therapy : indications, techniques and outcomes /

As proton therapy treatment centers become smaller and more cost-effective, education and training for today's multi-disciplinary oncology teams are more important than ever before.
Frank, Steven J.(Steven Jay),editor., Zhu, X. Ronald,editor.   +1 more
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Correction: Feasibility of linac-based fractionated stereotactic radiotherapy and stereotactic radiosurgery for patients with up to ten brain metastases

Radiation Oncology, 2023
Masanori Hirata, Kazuaki Yasui, Naofumi Oota, Hirofumi Ogawa, Tsuyoshi Onoe, Sayo Maki, Yusuke Ito, Kenji Hayashi, Hirofumi Asakura, Shigeyuki Murayama, Koichi Mitsuya, Shoichi Deguchi, Katsumasa Nakamura, Nakamasa Hayashi, Tetsuo Nishimura, Hideyuki Harada   +15 more
doaj   +1 more source

Gut Microbiota Regulates Systemic Inflammatory Response and Compensatory Anti‐Inflammatory Response Syndromes by Targeting PF4+ Macrophages in Acute Pancreatitis

Advanced Science, EarlyView.
ABSTRACT Acute pancreatitis (AP) begins with pancreatic local inflammation, leading to the onset of systemic inflammatory response syndrome (SIRS), followed by compensatory anti‐inflammatory response syndrome (CARS), which causes immune paralysis and higher mortality rate.
Liwei Liu, Guanqun Li, Dongxu Lu, Haoran Ding, Tianqi Lu, Yuhang Sui, Can Zhang, Yu Xie, Rui Kong, Hua Chen, Xuewei Bai, Hongtao Tan, Dongbo Xue, Xianzhi Meng, Le Li, Bei Sun   +15 more
wiley   +1 more source

A comparison of the quality assurance of four dosimetric tools for intensity modulated radiation therapy

Radiology and Oncology, 2015
Background. This study was designed to compare the quality assurance (QA) results of four dosimetric tools used for intensity modulated radiation therapy (IMRT) and to suggest universal criteria for the passing rate in QA, irrespective of the dosimetric ...
Son Jaeman, Baek Taesung, Lee Boram, Shin Dongho, Park Sung Yong, Park Jeonghoon, Lim Young Kyung, Lee Se Byeong, Kim Jooyoung, Yoon Myonggeun   +9 more
doaj   +1 more source

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

PAMELA : overview and status

, 2010
The status of the PAMELA (Particle Accelerator for MEdical Applications) project to design an accelerator for proton and light ion therapy using non-scaling Fixed Field Alternating Gradient (ns-FFAG) accelerators is reviewed and ...
Easton, M.J., Tzenov, S.I., Pasternak, J., Witte, H., Johnstone, C., Edgecock, T. R., Machida, S., Cobb, J., Barlow, R. J., Fenning, R.J.L., Vojnovic, B., Owen, H. L., Pattalwar, S., Jones, B., Yokoi, T., Tygier, S.C., Gardner, I.S.K., Witte, H, Hill, M.A., Beard, Carl, Peach, K., Fenning, R., Hill, M., Khan, A., McIntosh, P.A., Bliss, N., Seviour, R., Tygier, S., Edgecock, R., Kelliher, D.J., Tzenov, S., Jones, T.J., Cobb, J H, Smith, S. L., Peach, K. J., Kelliher, D., Pattalwar, S.M., Barlow, Roger, Sheehy, S. L., Aslaninejad, M., Easton, M., Beard, C.D., Pozimski, J.K., Owen, H., Gardner, I. S K, Seviour, Rebecca, Strachan, J., McIntosh, P., Pozimski, Jürgen Klaus, Smith, S.L., Jones, T.   +50 more
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