Results 131 to 140 of about 138,042 (257)

Integrating submandibular gland transfer with proton therapy to preserve salivary function. [PDF]

Clin Transl Radiat Oncol
Yarlagadda S, Young GD, Rohe RM, McNeill V, Nemec JR, Tohtz CP, Gonzalez L, McConnell KA, Kalman NS.   +8 more
europepmc   +1 more source

Investigations of the Evolved Molecular Basis for Terpenoid Biosynthesis in Marine Sponges

Advanced Science, EarlyView.
Confirming and extending a previous observation in another Bubarida sponge, genomic and functional analyses of A. cavernosa reveal that sponges retain the mevalonate pathway and employ single α‐domain T1TSs and UbiA‐type TSs for terpenoid biosynthesis. The absence of T1TSs clustering with other biosynthetic genes tentatively suggests, based on limited ...
Fangyan Chen, Bao Chen, Wenhui Zhang, Guifang Sun, Yao Zhao, Jianpeng Zhang, Baofu Xu   +6 more
wiley   +1 more source

Engineered Cyanobacteria‐Hydrogel Microecological System for Oxygen Reprogramming Synergizes Immunomodulation With Anabolism in Osteoarthritis Therapy

Advanced Science, EarlyView.
An injectable cyanobacteria‐laden hydrogel enables light‐dependent oxygen metabolism engineering for osteoarthritis therapy. Photosynthetic oxygen release under red light irradiation suppresses synovial inflammation via HIF‐1α inhibition and M2 macrophage polarization, while respiratory oxygen consumption in darkness stabilizes chondrocyte HIF‐1α to ...
Lerong Yang, Chong Shen, Hongjun Huang, Siyi Liu, Zeyu Huang, Licheng Xi, Huan Cao, Li Zheng, Zainen Qin   +8 more
wiley   +1 more source

Technical Considerations on Proton Therapy in NRG's Multi-Institutional Clinical Trials. [PDF]

Int J Radiat Oncol Biol Phys
Liang X, Taylor PA, Li H, Paganetti H, Pankuch M, Beltran CJ, Flampouri S, Hoppe BS, Kooy H, Lin H, Lin L, Liu W, Sahoo N, Simone CB, Teo BK, Xiao Y, Zhou J, Buchsbaum JC.   +17 more
europepmc   +1 more source

Supramolecular Degraders: An Emerging Paradigm in Targeted Protein Degradation

Advanced Science, EarlyView.
Dynamic supramolecular assembly reshapes targeted protein degradation by coordinating modular degrader construction, delivery, functional integration, and intracellular assembly or activation across proteasomal, endosomal–lysosomal, and autophagy–lysosomal pathways.
Kongjun Liu, Xue Yuan, Yan Zhou, Rui Yuan, Shaocheng Xie, Yong Chen, Peiyi Wang, Jianmei Gao, Qihai Gong   +8 more
wiley   +1 more source

Proton Therapy in the Management of Localized Prostate Cancer in Young Men. [PDF]

Int J Part Ther
Fortna M, Mendenhall NP, Lichlyter D, Jean-Baptiste S, Mendenhall WM, Charles Nichols R, Bryant CM.   +6 more
europepmc   +1 more source

Targeting β2‐Adrenergic Receptor Stability With Lycorine Reveals a Host‐Directed Pathway for Antiviral Defense Against Poxviruses

Advanced Science, EarlyView.
Chronic stress drives autophagy‐mediated β2‐AR degradation, impairing antiviral immunity and promoting poxvirus lethality. Lycorine directly stabilizes β2‐AR to restore host defense, suppress excessive inflammation and improve survival. ABSTRACT Psychological stress is a pervasive yet poorly understood modulator of infectious disease outcomes. Here, we
Xin Zhang, Shuqin Xu, Zixuan Zhang, Chenwen Wan, Xiaoqin Wang, Peihua Wang, Huini Yang, Tianxiao Huang, Yijia Yuan, Faiza Atique, Rui Yang, Yingli He, Zhijun Liu   +12 more
wiley   +1 more source

OPT-former: A transformer-based approach for eye motion tracking in ocular proton therapy. [PDF]

Med Phys
Pinori C, Ariata G, Hladchuk M, Pella A, Fiore MR, Magro G, Paganelli C, Chalaszczyk A, Rotondi M, Ciocca M, Baron G.   +10 more
europepmc   +1 more source

Nano Proton Scavengers Modulate Endosomal pH to Inhibit Microglial Activation and Enhance Stroke Recovery

Advanced Science, EarlyView.
Amphiphilic sulfonated chitosan nanoparticles buffer endo/lysosomal acidity in microglia by limiting V‐ATPase membrane recruitment and restoring endosomal homeostasis. Following systemic administration, they accumulate in the ischemic hemisphere partly through association with infiltrating immune cells, suppress TLR3/IRF3 and TLR4/NF‐κB signaling ...
Xuanlin Wang, Yujing Shi, Zehua Gao, Jing Wang, Changsheng Liu   +4 more
wiley   +1 more source

Modern proton therapy in prostate cancer: precision in practice. [PDF]

Front Oncol
Yacoub I, Khalil J, Wei S, Hsieh K, Chhabra AM, Mehta KJ, Oska C, Zhu L, Choi JI, Simone CB.   +9 more
europepmc   +1 more source