Results 141 to 150 of about 147,513 (305)

Fast Monte Carlo dose calculation in proton therapy. [PDF]

This article examines the critical role of fast Monte Carlo dose calculations in advancing proton therapy techniques, particularly in the context of increasing treatment customization and precision.
Zhang, Lian, Holmes, Jason, Fix, Michael K, Liu, Wei, Jiang, Steve B, Feng, Hongying   +5 more
core   +1 more source

Risk factors for radiation-induced rib fractures following proton beam therapy for stage I non-small cell lung cancer: a retrospective study

BMC Cancer
Background Understanding and managing radiation-induced adverse events is becoming increasingly important in hypofractionated radiotherapy due to the use of higher doses per fraction compared with conventional radiotherapy.
Naoaki Kondo, Takashi Yoshiura, Yasumasa Kakinohana, Mayumi Yamashita, Takeshi Arimura, Takashi Ogino   +5 more
doaj   +1 more source

m6A‐Mediated Glycolysis by IL‐37 Drives T Cell Metabolic Reprogramming to Regulate Colitis

Advanced Science, EarlyView.
This study identifies an IL‐37/SIGIRR‐METTL14 regulatory axis that suppresses global m6A modification in CD4+ T cells. IL‐37 signaling, mediated through SIGIRR, inhibits IRAK4 and JNK phosphorylation, leading to downregulation of the methyltransferase METTL14.
Xiaoyan Wang, Jiadong Yu, Guolin Li, Ya Li, Fanlian Zeng, Jing Hu, Yifan Zhou, Chengcheng Yue, Qixiang Zhao, Chen Zhang, Hong Zhou, Fulei Zhao, Yawen Hu, Pei Zhou, Linna Gu, Yuting Feng, Mingxiang He, Shishi Huang, Xiaochi Sun, Xinmeng Wang, Jie Tang, Xinyu Zeng, Wenling Wu, Nongyu Huang, Xinai Cui, Kaijun Cui, Jiong Li   +26 more
wiley   +1 more source

Evaluating the Impact of Bowel Gas Variations for Wilms’ Tumor in Pediatric Proton Therapy

(1) Background: Proton therapy, a precise form of radiation treatment, can be significantly affected by variations in bowel content. The purpose was to identify the most beneficial gantry angles that minimize deviations from the treatment plan quality ...
Dylan E. Graetz, Jinsoo Uh, Thomas E. Merchant, Fakhriddin Pirlepesov, Andrew M. Davidoff, Ozgur Ates, Chia-ho Hua, Matthew J. Krasin, Andrew Boria   +8 more
core   +1 more source

Comparative evaluation of static and dynamic 4D dose recalculations in pencil beam scanning proton therapy for oesophageal cancer

Physics and Imaging in Radiation Oncology
Background and purpose: The robustness of pencil beam scanned (PBS) proton plans to respiratory motion is often assessed in clinical practice by static 4D dose recalculations on selected 4D computed tomography (4DCT) phases.
Linus A. Carizzoni, Alexey Cherchik, Xia Li, Antony Lomax, Ye Zhang   +4 more
doaj   +1 more source

Carboranyl‐Curcuminoids for the Neutron Capture‐Based Treatment of Amyloid Aggregates in Alzheimer's Disease

Advanced Science, EarlyView.
The 10B‐enriched monocarbonyl analog of curcumin (BMAC) 10B‐9 enables site‐specific Boron Neutron Capture Therapy (BNCT) on amyloid‐β (Aβ) fibrils. Neutron irradiation induces histidine oxidation and fibril destabilization, as revealed by 1H‐NMR and FESEM analyses.
Sebastiano Micocci, Stefano Parisotto, Diego Alberti, Alberto Lanfranco, Valeria Bitonto, Polyssena Renzi, Martina Salmi, Andrea Magnani, Federica Dal Bello, Katiuscia Pagano, Laura Ragona, Nicoletta Protti, Annamaria Deagostino, Simonetta Geninatti Crich   +13 more
wiley   +1 more source

Potential of a compact low energy proton accelertor for medical applications

This thesis explores the potential of a compact low energy (
Ratcliffe, Naomi
core  

Lipoic Acid‐Intervened Decellularized Stem Cell Spheroid‐Based Injectable Granular Gel for Diabetic Tissue Regeneration

Advanced Science, EarlyView.
ABSTRACT Advancements in tissue engineering have revolutionized therapeutic paradigms for diabetic tissue defects; however, the lack of applicable scaffold containing various bioactive substance aggregates remained a critical bottleneck hindering satisfactory repair effect.
Tao Wang, Haowei Fang, Lili Qi, Song Myoungseop, Aawrish Khan, Lunli Gong, Guangdong Zhou, Kunxi Zhang, Haiyan Cui   +8 more
wiley   +1 more source

Dosimetric Advantage of Scanning Beam Proton Therapy in Gynecologic Patients Receiving Adjuvant Radiotherapy

Background/Objectives: Adjuvant radiation for gynecologic malignancies often exposes organs at risk (OARs), such as the bone marrow, bowel, rectum, and bladder, to radiation, leading to toxicities that impact treatment tolerance and patient quality of ...
Ger, Rachel B, Lemish, Pamela R, Bues, Martin, Justin D. Anderson, Christopher J. Kutyreff, Ridgway, Ana K, Christie A. Schulz, Pedro R. Lara, Anand, Aman, Martin Bues, Danairis Hernandez Morales, Niedzielski, Joshua S, Kutyreff, Christopher J, Rachel B. Ger, Aman Anand, Justin D. Gagneur, Lara, Pedro R, Vora, Sujay A, Schulz, Christie A, Joshua S. Niedzielski, Pamela R. Lemish, Ana K. Ridgway, Jarrod M. Lentz, Sujay A. Vora, Hernandez Morales, Danairis, Gagneur, Justin D, Lentz, Jarrod M, Anderson, Justin D   +27 more
core   +1 more source

RBM10 Deficiency Promotes Anti‐PD‐1 Resistance in LUAD via STING Alternative Splicing‐Driven CCL7 Signaling and Macrophage Polarization

Advanced Science, EarlyView.
RBM10 deficiency promotes anti‐PD‐1 resistance in lung adenocarcinoma by altering STING alternative splicing, which enhances CCL7 secretion and CCR2‐dependent M2 macrophage polarization. A positive feedback loop via mitochondrial transfer sustains this immunosuppression.
Weitong Gao, Ruqiong Wang, Bo An, Lishuang Qi, Zihan Jing, Xingmei Ren, Yang Zhou, Mingjun Xu, Jiaojiao Li, Jie Liu, Liying Wang, Gang Xu, Rou Li, Dexin Jia, Yan Yu   +14 more
wiley   +1 more source